Skin cancer and Parkinson's disease.
Identifieur interne : 002960 ( Ncbi/Curation ); précédent : 002959; suivant : 002961Skin cancer and Parkinson's disease.
Auteurs : Joaquim J. Ferreira [Portugal] ; Dulce Neutel ; Tiago Mestre ; Miguel Coelho ; Mário M. Rosa ; Olivier Rascol ; Cristina SampaioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Breast Neoplasms (epidemiology), Breast Neoplasms (etiology), Female, Humans, Melanoma (chemically induced), Melanoma (epidemiology), Melanoma (etiology), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Risk Factors, Skin Neoplasms (chemically induced), Skin Neoplasms (epidemiology), Skin Neoplasms (etiology), Thyroid Neoplasms (epidemiology), Thyroid Neoplasms (etiology).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents.
- chemical , adverse effects : Antiparkinson Agents.
- chemically induced : Melanoma, Skin Neoplasms.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- epidemiology : Breast Neoplasms, Melanoma, Parkinson Disease, Skin Neoplasms, Thyroid Neoplasms.
- etiology : Breast Neoplasms, Melanoma, Skin Neoplasms, Thyroid Neoplasms.
- Female, Humans, Risk Factors.
Abstract
The report of an increased frequency of melanoma during the clinical development of rasagiline prompted a renewed interest in a possible association between skin cancer and Parkinson's disease (PD). The evaluation of this risk ended in a recommendation to perform a periodic dermatological examination as a follow-up measure of their treatment. The recognition of this safety concern lead to the need to clarify if the risk of skin cancer is indeed associated with PD and if levodopa or other anti-parkinsonian drugs might contribute to increase such risk. To answer these questions, we critically reviewed all clinical studies available concerning the association between skin cancer and PD. We found 26 studies on cancer occurrence in PD. The best data available suggest the risk of cancer is reduced in PD patients. However, specific cancers like thyroid and the female breast were reported at higher-than-expected rates. Additionally, it was suggested that PD patients have a higher frequency of melanoma and non-melanoma skin cancers than the general population. The data on non-melanoma skin cancer are less robust than the data on melanoma. Causal factors remain unknown. Due to the weak association between skin cancer and PD, no robust recommendation can be made regarding the need for periodic dermatological screening.
DOI: 10.1002/mds.22855
PubMed: 20063399
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pubmed:20063399Le document en format XML
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<author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name>
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<term>Skin Neoplasms (epidemiology)</term>
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<front><div type="abstract" xml:lang="en">The report of an increased frequency of melanoma during the clinical development of rasagiline prompted a renewed interest in a possible association between skin cancer and Parkinson's disease (PD). The evaluation of this risk ended in a recommendation to perform a periodic dermatological examination as a follow-up measure of their treatment. The recognition of this safety concern lead to the need to clarify if the risk of skin cancer is indeed associated with PD and if levodopa or other anti-parkinsonian drugs might contribute to increase such risk. To answer these questions, we critically reviewed all clinical studies available concerning the association between skin cancer and PD. We found 26 studies on cancer occurrence in PD. The best data available suggest the risk of cancer is reduced in PD patients. However, specific cancers like thyroid and the female breast were reported at higher-than-expected rates. Additionally, it was suggested that PD patients have a higher frequency of melanoma and non-melanoma skin cancers than the general population. The data on non-melanoma skin cancer are less robust than the data on melanoma. Causal factors remain unknown. Due to the weak association between skin cancer and PD, no robust recommendation can be made regarding the need for periodic dermatological screening.</div>
</front>
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