Quantitative lateralized measures of bradykinesia at different stages of Parkinson's disease: the role of the less affected side.
Identifieur interne : 002783 ( Ncbi/Curation ); précédent : 002782; suivant : 002784Quantitative lateralized measures of bradykinesia at different stages of Parkinson's disease: the role of the less affected side.
Auteurs : Stephanie Louie [États-Unis] ; Mandy Miller Koop ; Anna Frenklach ; Helen Bronte-StewartSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Diagnosis, Computer-Assisted, Disability Evaluation, Disease Progression, Female, Fingers (physiopathology), Functional Laterality (physiology), Humans, Hypokinesia (diagnosis), Hypokinesia (etiology), Hypokinesia (pathology), Male, Middle Aged, Parkinson Disease (complications), Postural Balance, Psychomotor Performance (physiology), Severity of Illness Index.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Hypokinesia.
- etiology : Hypokinesia.
- pathology : Hypokinesia.
- physiology : Functional Laterality, Psychomotor Performance.
- physiopathology : Fingers.
- Aged, Case-Control Studies, Diagnosis, Computer-Assisted, Disability Evaluation, Disease Progression, Female, Humans, Male, Middle Aged, Postural Balance, Severity of Illness Index.
Abstract
The onset of motor abnormalities in Parkinson's disease (PD) is usually unilateral. However, current therapeutic trials do not analyze separately the performance of the more affected (MA) and less affected (LA) limbs. From a cohort of 85 subjects at different stages of PD, we asked whether the relationship between bradykinesia and disease severity was similar on both limbs and if the MA side remained more bradykinetic than the LA side in advanced PD. MA and LA limb determination was made from the history of the side first affected. Twenty-one age-matched subjects were used as controls. The velocities of finger and arm movements on both sides were inversely correlated with disease severity (P < 0.03). The slope of the decline in wrist movement velocity was steeper on the LA side (P = 0.029). When the regression lines were extrapolated to the y-axis (UPDRS III = 0) the performance of the LA side was not different from that of controls (P = 0.954 and P = 0.829 for finger and arm movements, respectively), whereas that of the MA side was slower (P = 0.019 and P = 0.016), suggesting that at the theoretical state of no disease the LA side would reflect less or no contralateral nigral pathology. With increasing disease severity, there was less difference between MA and LA sides in both finger and arm bradykinesia (P < 0.004). These findings highlight the value of analyzing separately the MA and LA sides in subjects with PD, especially for clinical trials of potential disease modifying agents in early stages of disease.
DOI: 10.1002/mds.22741
PubMed: 19672996
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However, current therapeutic trials do not analyze separately the performance of the more affected (MA) and less affected (LA) limbs. From a cohort of 85 subjects at different stages of PD, we asked whether the relationship between bradykinesia and disease severity was similar on both limbs and if the MA side remained more bradykinetic than the LA side in advanced PD. MA and LA limb determination was made from the history of the side first affected. Twenty-one age-matched subjects were used as controls. The velocities of finger and arm movements on both sides were inversely correlated with disease severity (P < 0.03). The slope of the decline in wrist movement velocity was steeper on the LA side (P = 0.029). When the regression lines were extrapolated to the y-axis (UPDRS III = 0) the performance of the LA side was not different from that of controls (P = 0.954 and P = 0.829 for finger and arm movements, respectively), whereas that of the MA side was slower (P = 0.019 and P = 0.016), suggesting that at the theoretical state of no disease the LA side would reflect less or no contralateral nigral pathology. With increasing disease severity, there was less difference between MA and LA sides in both finger and arm bradykinesia (P < 0.004). These findings highlight the value of analyzing separately the MA and LA sides in subjects with PD, especially for clinical trials of potential disease modifying agents in early stages of disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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