Correlations between gray matter reductions and cognitive deficits in dementia with Lewy Bodies and Parkinson's disease with dementia.
Identifieur interne : 002749 ( Ncbi/Curation ); précédent : 002748; suivant : 002750Correlations between gray matter reductions and cognitive deficits in dementia with Lewy Bodies and Parkinson's disease with dementia.
Auteurs : Cristina Sanchez-Castaneda [Espagne] ; Ramon Rene ; Blanca Ramirez-Ruiz ; Jaume Campdelacreu ; Jordi Gascon ; Carles Falcon ; Matilde Calopa ; Serge Jauma ; Montserrat Juncadella ; Carme JunqueSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Analysis of Variance, Brain (pathology), Brain Mapping, Cognition Disorders (etiology), Cognition Disorders (pathology), Female, Humans, Lewy Body Disease (complications), Lewy Body Disease (pathology), Magnetic Resonance Imaging (methods), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (pathology), Psychiatric Status Rating Scales, Statistics as Topic, Statistics, Nonparametric.
- MESH :
- complications : Lewy Body Disease, Parkinson Disease.
- etiology : Cognition Disorders.
- methods : Magnetic Resonance Imaging.
- pathology : Brain, Cognition Disorders, Lewy Body Disease, Parkinson Disease.
- Aged, Aged, 80 and over, Analysis of Variance, Brain Mapping, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Statistics as Topic, Statistics, Nonparametric.
Abstract
There is controversy regarding whether Dementia with Lewy Bodies (DLB) and Parkinson's disease with dementia (PDD) may or not be different manifestations of the same disorder. The purpose of the present study was to investigate possible correlations between brain structure and neuropsychological functions in clinically diagnosed patients with DLB and PDD. The study sample consisted of 12 consecutively referred DLB patients, 16 PDD patients, and 16 healthy control subjects recruited from an outpatient setting, who underwent MRI and neuropsychological assessment. Voxel-based morphometry results showed that DLB patients had greater gray matter atrophy in the right superior frontal gyrus, the right premotor area and the right inferior frontal lobe compared to PDD. Furthermore, the anterior cingulate and prefrontal volume correlated with performance on the Continuous Performance Test while the right hippocampus and amygdala volume correlated with Visual Memory Test in the DLB group. In conclusion, DLB patients had more fronto-temporal gray matter atrophy than PDD patients and these reductions correlated with neuropsychological impairment.
DOI: 10.1002/mds.22488
PubMed: 19569130
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sortKey="Ramirez Ruiz, Blanca" sort="Ramirez Ruiz, Blanca" uniqKey="Ramirez Ruiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name></author><author><name sortKey="Campdelacreu, Jaume" sort="Campdelacreu, Jaume" uniqKey="Campdelacreu J" first="Jaume" last="Campdelacreu">Jaume Campdelacreu</name></author><author><name sortKey="Gascon, Jordi" sort="Gascon, Jordi" uniqKey="Gascon J" first="Jordi" last="Gascon">Jordi Gascon</name></author><author><name sortKey="Falcon, Carles" sort="Falcon, Carles" uniqKey="Falcon C" first="Carles" last="Falcon">Carles Falcon</name></author><author><name sortKey="Calopa, Matilde" sort="Calopa, Matilde" uniqKey="Calopa M" first="Matilde" last="Calopa">Matilde Calopa</name></author><author><name sortKey="Jauma, Serge" sort="Jauma, Serge" uniqKey="Jauma S" first="Serge" last="Jauma">Serge Jauma</name></author><author><name sortKey="Juncadella, Montserrat" sort="Juncadella, Montserrat" uniqKey="Juncadella M" first="Montserrat" last="Juncadella">Montserrat Juncadella</name></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22488</idno><idno type="RBID">pubmed:19569130</idno><idno type="pmid">19569130</idno><idno type="wicri:Area/PubMed/Corpus">001C28</idno><idno type="wicri:Area/PubMed/Curation">001C28</idno><idno type="wicri:Area/PubMed/Checkpoint">001E78</idno><idno type="wicri:Area/Ncbi/Merge">002749</idno><idno type="wicri:Area/Ncbi/Curation">002749</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Correlations between gray matter reductions and cognitive deficits in dementia with Lewy Bodies and Parkinson's disease with dementia.</title><author><name sortKey="Sanchez Castaneda, Cristina" sort="Sanchez Castaneda, Cristina" uniqKey="Sanchez Castaneda C" first="Cristina" last="Sanchez-Castaneda">Cristina Sanchez-Castaneda</name><affiliation wicri:level="3"><nlm:affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rene, Ramon" sort="Rene, Ramon" uniqKey="Rene R" first="Ramon" last="Rene">Ramon Rene</name></author><author><name sortKey="Ramirez Ruiz, Blanca" sort="Ramirez Ruiz, Blanca" uniqKey="Ramirez Ruiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name></author><author><name sortKey="Campdelacreu, Jaume" sort="Campdelacreu, Jaume" uniqKey="Campdelacreu J" first="Jaume" last="Campdelacreu">Jaume Campdelacreu</name></author><author><name sortKey="Gascon, Jordi" sort="Gascon, Jordi" uniqKey="Gascon J" first="Jordi" last="Gascon">Jordi Gascon</name></author><author><name sortKey="Falcon, Carles" sort="Falcon, Carles" uniqKey="Falcon C" first="Carles" last="Falcon">Carles Falcon</name></author><author><name sortKey="Calopa, Matilde" sort="Calopa, Matilde" uniqKey="Calopa M" first="Matilde" last="Calopa">Matilde Calopa</name></author><author><name sortKey="Jauma, Serge" sort="Jauma, Serge" uniqKey="Jauma S" first="Serge" last="Jauma">Serge Jauma</name></author><author><name sortKey="Juncadella, Montserrat" sort="Juncadella, Montserrat" uniqKey="Juncadella M" first="Montserrat" last="Juncadella">Montserrat Juncadella</name></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Brain (pathology)</term><term>Brain Mapping</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (pathology)</term><term>Female</term><term>Humans</term><term>Lewy Body Disease (complications)</term><term>Lewy Body Disease (pathology)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Psychiatric Status Rating Scales</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Cognition Disorders</term><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychiatric Status Rating Scales</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is controversy regarding whether Dementia with Lewy Bodies (DLB) and Parkinson's disease with dementia (PDD) may or not be different manifestations of the same disorder. The purpose of the present study was to investigate possible correlations between brain structure and neuropsychological functions in clinically diagnosed patients with DLB and PDD. The study sample consisted of 12 consecutively referred DLB patients, 16 PDD patients, and 16 healthy control subjects recruited from an outpatient setting, who underwent MRI and neuropsychological assessment. Voxel-based morphometry results showed that DLB patients had greater gray matter atrophy in the right superior frontal gyrus, the right premotor area and the right inferior frontal lobe compared to PDD. Furthermore, the anterior cingulate and prefrontal volume correlated with performance on the Continuous Performance Test while the right hippocampus and amygdala volume correlated with Visual Memory Test in the DLB group. In conclusion, DLB patients had more fronto-temporal gray matter atrophy than PDD patients and these reductions correlated with neuropsychological impairment.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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