Movement Disorders (revue)

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Bell's palsy preceding Parkinson's disease: a case-control study.

Identifieur interne : 002725 ( Ncbi/Curation ); précédent : 002724; suivant : 002726

Bell's palsy preceding Parkinson's disease: a case-control study.

Auteurs : Rodolfo Savica [États-Unis] ; James H. Bower ; Demetrius M. Maraganore ; Brandon R. Grossardt ; Walter A. Rocca

Source :

RBID : pubmed:19526588

English descriptors

Abstract

We investigated the association of Bell's palsy (BP) with the subsequent risk of Parkinson's disease (PD) using a case-control study design. We matched 196 incident cases of PD in Olmsted County, MN, to 196 general population controls with same age (+/-1 year) and sex, and we reviewed the complete medical records of cases and controls in a medical records-linkage system to detect BP. Six of the 196 patients with PD and none of the 196 controls were diagnosed with BP before PD (exact binomial probability, P = 0.02). The median age at occurrence of BP was 49.5 years (range, 15-84 years) and the median time between BP and the onset of PD was 27.5 years (range, 2-54 years). The findings were similar using a standardized incidence ratio (SIR) approach, but were not statistically significant. This initial association between BP and PD awaits replication.

DOI: 10.1002/mds.22616
PubMed: 19526588

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<nlm:affiliation>Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation>
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<div type="abstract" xml:lang="en">We investigated the association of Bell's palsy (BP) with the subsequent risk of Parkinson's disease (PD) using a case-control study design. We matched 196 incident cases of PD in Olmsted County, MN, to 196 general population controls with same age (+/-1 year) and sex, and we reviewed the complete medical records of cases and controls in a medical records-linkage system to detect BP. Six of the 196 patients with PD and none of the 196 controls were diagnosed with BP before PD (exact binomial probability, P = 0.02). The median age at occurrence of BP was 49.5 years (range, 15-84 years) and the median time between BP and the onset of PD was 27.5 years (range, 2-54 years). The findings were similar using a standardized incidence ratio (SIR) approach, but were not statistically significant. This initial association between BP and PD awaits replication.</div>
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