Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs.
Identifieur interne : 002655 ( Ncbi/Curation ); précédent : 002654; suivant : 002656Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs.
Auteurs : Susanne A. Schneider [Royaume-Uni] ; Vrajesh Udani ; Charulata Sawant Sankhla ; Kailash P. BhatiaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Dopamine Antagonists.
- chemically induced : Dystonia, Ocular Motility Disorders.
- methods : Electroencephalography.
- Adult, Child, Disease Progression, Dyskinesia, Drug-Induced, Female, Humans, Male.
Abstract
Adverse events of dopamine-blocking agents include acute dystonic reactions and oculogyric crises (OGCs). OGCs may be recurrent on maintenance of or re-exposure to the drug. Thus, complete withdrawal is recommended. Recurrent episodes of acute dystonia despite withdrawal and the lack of further exposure to antidopaminergic agents are usually not seen. Here, we report three cases with recurrent OGCs despite complete withdrawal of neuroleptics. Triggering or priming factors were a single dose of haloperidol in two cases and a single dose of metoclopramide in one case. Episodes reoccurred spontaneously, but responded to anticholinergics. The pathomechanisms of acute dystonic reactions and OGCs remain unclear. Parallels to levodopa-induced dyskinesias in Parkinson's disease, as well as to dopa-responsive dystonia, paroxysmal dyskinesias, and channelopathies are discussed here. Whether there is a genetic susceptibility or some other reason for only some patients developing this phenomenon remains unclear.
DOI: 10.1002/mds.22532
PubMed: 19412963
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pubmed:19412963Le document en format XML
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Schneider</name><affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Udani, Vrajesh" sort="Udani, Vrajesh" uniqKey="Udani V" first="Vrajesh" last="Udani">Vrajesh Udani</name></author><author><name sortKey="Sankhla, Charulata Sawant" sort="Sankhla, Charulata Sawant" uniqKey="Sankhla C" first="Charulata Sawant" last="Sankhla">Charulata Sawant Sankhla</name></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P" last="Bhatia">Kailash P. Bhatia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22532</idno><idno type="RBID">pubmed:19412963</idno><idno type="pmid">19412963</idno><idno type="wicri:Area/PubMed/Corpus">001D22</idno><idno type="wicri:Area/PubMed/Curation">001D22</idno><idno type="wicri:Area/PubMed/Checkpoint">001C00</idno><idno type="wicri:Area/Ncbi/Merge">002655</idno><idno type="wicri:Area/Ncbi/Curation">002655</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs.</title><author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A" last="Schneider">Susanne A. Schneider</name><affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Udani, Vrajesh" sort="Udani, Vrajesh" uniqKey="Udani V" first="Vrajesh" last="Udani">Vrajesh Udani</name></author><author><name sortKey="Sankhla, Charulata Sawant" sort="Sankhla, Charulata Sawant" uniqKey="Sankhla C" first="Charulata Sawant" last="Sankhla">Charulata Sawant Sankhla</name></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P" last="Bhatia">Kailash P. Bhatia</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Child</term><term>Disease Progression</term><term>Dopamine Antagonists (adverse effects)</term><term>Dyskinesia, Drug-Induced</term><term>Dystonia (chemically induced)</term><term>Electroencephalography (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Ocular Motility Disorders (chemically induced)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine Antagonists</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Dystonia</term><term>Ocular Motility Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electroencephalography</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Child</term><term>Disease Progression</term><term>Dyskinesia, Drug-Induced</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Adverse events of dopamine-blocking agents include acute dystonic reactions and oculogyric crises (OGCs). OGCs may be recurrent on maintenance of or re-exposure to the drug. Thus, complete withdrawal is recommended. Recurrent episodes of acute dystonia despite withdrawal and the lack of further exposure to antidopaminergic agents are usually not seen. Here, we report three cases with recurrent OGCs despite complete withdrawal of neuroleptics. Triggering or priming factors were a single dose of haloperidol in two cases and a single dose of metoclopramide in one case. Episodes reoccurred spontaneously, but responded to anticholinergics. The pathomechanisms of acute dystonic reactions and OGCs remain unclear. Parallels to levodopa-induced dyskinesias in Parkinson's disease, as well as to dopa-responsive dystonia, paroxysmal dyskinesias, and channelopathies are discussed here. Whether there is a genetic susceptibility or some other reason for only some patients developing this phenomenon remains unclear.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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