Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease.
Identifieur interne : 002461 ( Ncbi/Curation ); précédent : 002460; suivant : 002462Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease.
Auteurs : Aleksandar Rakovic [Allemagne] ; Barbara Stiller ; Ana Djarmati ; Antonia Flaquer ; Jan Freudenberg ; Mohammad-Reza Toliat ; Michael Linnebank ; Vladimir Kostic ; Katja Lohmann ; Sebastian Paus ; Peter Nürnberg ; Christian Kubisch ; Christine Klein ; Ullrich Wüllner ; Alfredo RamirezSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Proton-Translocating ATPases.
- genetics : Parkinson Disease, Polymorphism, Single Nucleotide.
- Adult, Age of Onset, Aged, Female, Genotype, Haplotypes, Humans, Male, Middle Aged.
Abstract
A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (P(UNC) = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD.
DOI: 10.1002/mds.22399
PubMed: 19097176
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease.</title>
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<term>Male</term>
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<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Proton-Translocating ATPases (genetics)</term>
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<term>Polymorphism, Single Nucleotide</term>
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<front><div type="abstract" xml:lang="en">A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (P(UNC) = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD.</div>
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