Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome.
Identifieur interne : 002277 ( Ncbi/Curation ); précédent : 002276; suivant : 002278Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome.
Auteurs : Malek I. Makki [États-Unis] ; Michael Behen ; Arpi Bhatt ; Benjamin Wilson ; Harry T. ChuganiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- pathology : Corpus Striatum, Thalamus, Tourette Syndrome.
- physiopathology : Tourette Syndrome.
- Adolescent, Brain Mapping, Case-Control Studies, Chi-Square Distribution, Child, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Neuropsychological Tests.
Abstract
We applied diffusion-tensor MRI (DT-MRI) to investigate directly the water diffusivity within subcortical gray matter structures comprising the fronto-striato-thalamic (FST) circuit, which is implicated in the pathophysiology of Tourette syndrome (TS). We investigated the structural integrity of basal ganglia and thalamus in 23 children with TS and 35 age-matched healthy controls (NC), and examined the association of DT-MRI measures to tic severity and comorbid symptoms. We measured parallel (lambda(1)) and perpendicular (lambda(23)) diffusivity, mean diffusivity (MD), and fractional anisotropy (FA) in both hemispheres. Compared with NC, the TS group showed a significant increase in lambda(1) (P = 0.003) and MD (P = 0.027) in the bilateral putamen, an increase in lambda(23) in right thalamus (P = 0.008), and a reversed asymmetry of FA (P = 0.03) in the thalamus. There was a significant positive correlation between lambda(23) in right thalamus and tic severity. TS patients showed significantly lower left caudate volume (P = 0.011) and bilateral thalamic volumes (left, P = 0.035, right P = 0.006) compared with NC. These findings support the notion that microstructural dysfunction measured by DT-MRI in component regions of the FST circuit contribute to the pathophysiology in TS.
DOI: 10.1002/mds.22264
PubMed: 18759338
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002086
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002086
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002220
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002277
Links to Exploration step
pubmed:18759338Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome.</title><author><name sortKey="Makki, Malek I" sort="Makki, Malek I" uniqKey="Makki M" first="Malek I" last="Makki">Malek I. Makki</name><affiliation wicri:level="2"><nlm:affiliation>Radiology Department, Wayne State University School of Medicine, Detroit, Michigan, USA. malek@pet.wayne.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Radiology Department, Wayne State University School of Medicine, Detroit, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Behen, Michael" sort="Behen, Michael" uniqKey="Behen M" first="Michael" last="Behen">Michael Behen</name></author><author><name sortKey="Bhatt, Arpi" sort="Bhatt, Arpi" uniqKey="Bhatt A" first="Arpi" last="Bhatt">Arpi Bhatt</name></author><author><name sortKey="Wilson, Benjamin" sort="Wilson, Benjamin" uniqKey="Wilson B" first="Benjamin" last="Wilson">Benjamin Wilson</name></author><author><name sortKey="Chugani, Harry T" sort="Chugani, Harry T" uniqKey="Chugani H" first="Harry T" last="Chugani">Harry T. Chugani</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22264</idno><idno type="RBID">pubmed:18759338</idno><idno type="pmid">18759338</idno><idno type="wicri:Area/PubMed/Corpus">002086</idno><idno type="wicri:Area/PubMed/Curation">002086</idno><idno type="wicri:Area/PubMed/Checkpoint">002220</idno><idno type="wicri:Area/Ncbi/Merge">002277</idno><idno type="wicri:Area/Ncbi/Curation">002277</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome.</title><author><name sortKey="Makki, Malek I" sort="Makki, Malek I" uniqKey="Makki M" first="Malek I" last="Makki">Malek I. Makki</name><affiliation wicri:level="2"><nlm:affiliation>Radiology Department, Wayne State University School of Medicine, Detroit, Michigan, USA. malek@pet.wayne.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Radiology Department, Wayne State University School of Medicine, Detroit, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Behen, Michael" sort="Behen, Michael" uniqKey="Behen M" first="Michael" last="Behen">Michael Behen</name></author><author><name sortKey="Bhatt, Arpi" sort="Bhatt, Arpi" uniqKey="Bhatt A" first="Arpi" last="Bhatt">Arpi Bhatt</name></author><author><name sortKey="Wilson, Benjamin" sort="Wilson, Benjamin" uniqKey="Wilson B" first="Benjamin" last="Wilson">Benjamin Wilson</name></author><author><name sortKey="Chugani, Harry T" sort="Chugani, Harry T" uniqKey="Chugani H" first="Harry T" last="Chugani">Harry T. Chugani</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Child</term><term>Corpus Striatum (pathology)</term><term>Diffusion Magnetic Resonance Imaging</term><term>Female</term><term>Humans</term><term>Male</term><term>Neuropsychological Tests</term><term>Thalamus (pathology)</term><term>Tourette Syndrome (pathology)</term><term>Tourette Syndrome (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Thalamus</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Child</term><term>Diffusion Magnetic Resonance Imaging</term><term>Female</term><term>Humans</term><term>Male</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We applied diffusion-tensor MRI (DT-MRI) to investigate directly the water diffusivity within subcortical gray matter structures comprising the fronto-striato-thalamic (FST) circuit, which is implicated in the pathophysiology of Tourette syndrome (TS). We investigated the structural integrity of basal ganglia and thalamus in 23 children with TS and 35 age-matched healthy controls (NC), and examined the association of DT-MRI measures to tic severity and comorbid symptoms. We measured parallel (lambda(1)) and perpendicular (lambda(23)) diffusivity, mean diffusivity (MD), and fractional anisotropy (FA) in both hemispheres. Compared with NC, the TS group showed a significant increase in lambda(1) (P = 0.003) and MD (P = 0.027) in the bilateral putamen, an increase in lambda(23) in right thalamus (P = 0.008), and a reversed asymmetry of FA (P = 0.03) in the thalamus. There was a significant positive correlation between lambda(23) in right thalamus and tic severity. TS patients showed significantly lower left caudate volume (P = 0.011) and bilateral thalamic volumes (left, P = 0.035, right P = 0.006) compared with NC. These findings support the notion that microstructural dysfunction measured by DT-MRI in component regions of the FST circuit contribute to the pathophysiology in TS.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002277 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 002277 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:18759338
|texte= Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:18759338" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |