Dopaminergic deficit is not the rule in orthostatic tremor.
Identifieur interne : 002233 ( Ncbi/Curation ); précédent : 002232; suivant : 002234Dopaminergic deficit is not the rule in orthostatic tremor.
Auteurs : Jean-Marc Trocello [France] ; Paolo Zanotti-Fregonara ; Emmanuel Roze ; Emmanuelle Apartis ; André-Pierre Legrand ; Marie-Odile Habert ; Jean-Yves Devaux ; Marie VidailhetSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- chemical , deficiency : Dopamine.
- chemical , diagnostic use : Tropanes.
- chemical , physiology : Dopamine.
- drug therapy : Tremor.
- methods : Tomography, Emission-Computed, Single-Photon.
- physiopathology : Tremor.
- radionuclide imaging : Tremor.
- Aged, Brain Mapping, Electromyography, Female, Humans, Male, Middle Aged.
Abstract
Involvement of the dopaminergic system in orthostatic tremor is controversial. The aim of this study was to detect possible dopaminergic denervation in primary orthostatic tremor (OT). Twelve consecutive patients with a firm diagnosis of primary orthostatic tremor were compared with age-matched normal controls. All the patients had a neurological examination, surface polymyography, and quantification of striatal dopamine transporters with (123)I-FP-CIT SPECT imaging. There was no significant difference in (123)I-FP-CIT SPECT findings between controls and patients with OT. Longstanding primary orthostatic tremor is not necessarily associated with (123)I-FP-CIT SPECT abnormalities, as 8 of our patients had more than a 10-year history of OT. Primary orthostatic tremor without dopaminergic denervation remains a valid entity, although representing only a subtype of high-frequency OT. A new role may emerge for (123)I-FP-CIT SPECT in distinguishing between patients whose symptoms will be restricted to OT throughout the disease course and patients at an increased risk of developing PD. (c) 2008 Movement Disorder Society.
DOI: 10.1002/mds.22224
PubMed: 18661569
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Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name></author><author><name sortKey="Legrand, Andre Pierre" sort="Legrand, Andre Pierre" uniqKey="Legrand A" first="André-Pierre" last="Legrand">André-Pierre Legrand</name></author><author><name sortKey="Habert, Marie Odile" sort="Habert, Marie Odile" uniqKey="Habert M" first="Marie-Odile" last="Habert">Marie-Odile Habert</name></author><author><name sortKey="Devaux, Jean Yves" sort="Devaux, Jean Yves" uniqKey="Devaux J" first="Jean-Yves" last="Devaux">Jean-Yves Devaux</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22224</idno><idno type="RBID">pubmed:18661569</idno><idno type="pmid">18661569</idno><idno 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Fregonara P" first="Paolo" last="Zanotti-Fregonara">Paolo Zanotti-Fregonara</name></author><author><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name></author><author><name sortKey="Apartis, Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name></author><author><name sortKey="Legrand, Andre Pierre" sort="Legrand, Andre Pierre" uniqKey="Legrand A" first="André-Pierre" last="Legrand">André-Pierre Legrand</name></author><author><name sortKey="Habert, Marie Odile" sort="Habert, Marie Odile" uniqKey="Habert M" first="Marie-Odile" last="Habert">Marie-Odile Habert</name></author><author><name sortKey="Devaux, Jean Yves" sort="Devaux, Jean Yves" uniqKey="Devaux J" first="Jean-Yves" last="Devaux">Jean-Yves Devaux</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Dopamine (deficiency)</term><term>Dopamine (physiology)</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tremor (drug therapy)</term><term>Tremor (physiopathology)</term><term>Tremor (radionuclide imaging)</term><term>Tropanes (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Involvement of the dopaminergic system in orthostatic tremor is controversial. The aim of this study was to detect possible dopaminergic denervation in primary orthostatic tremor (OT). Twelve consecutive patients with a firm diagnosis of primary orthostatic tremor were compared with age-matched normal controls. All the patients had a neurological examination, surface polymyography, and quantification of striatal dopamine transporters with (123)I-FP-CIT SPECT imaging. There was no significant difference in (123)I-FP-CIT SPECT findings between controls and patients with OT. Longstanding primary orthostatic tremor is not necessarily associated with (123)I-FP-CIT SPECT abnormalities, as 8 of our patients had more than a 10-year history of OT. Primary orthostatic tremor without dopaminergic denervation remains a valid entity, although representing only a subtype of high-frequency OT. A new role may emerge for (123)I-FP-CIT SPECT in distinguishing between patients whose symptoms will be restricted to OT throughout the disease course and patients at an increased risk of developing PD. (c) 2008 Movement Disorder Society.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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