Lack of trigemino-cervical reflexes in progressive supranuclear palsy.
Identifieur interne : 002186 ( Ncbi/Curation ); précédent : 002185; suivant : 002187Lack of trigemino-cervical reflexes in progressive supranuclear palsy.
Auteurs : Michelangelo Bartolo [Italie] ; Mariano Serrao ; Armando Perrotta ; Cristina Tassorelli ; Giorgio Sandrini ; Francesco PierelliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Brain Stem (physiopathology), Electric Stimulation, Electromyography, Female, Head Movements (physiology), Humans, Male, Middle Aged, Motor Neurons (physiology), Muscle Contraction, Neck Muscles (innervation), Neck Muscles (physiopathology), Neural Pathways (physiopathology), Reflex, Abnormal, Spinal Cord (physiopathology), Supranuclear Palsy, Progressive (physiopathology), Trigeminal Nerve (physiopathology).
- MESH :
- innervation : Neck Muscles.
- physiology : Head Movements, Motor Neurons.
- physiopathology : Brain Stem, Neck Muscles, Neural Pathways, Spinal Cord, Supranuclear Palsy, Progressive, Trigeminal Nerve.
- Aged, Electric Stimulation, Electromyography, Female, Humans, Male, Middle Aged, Muscle Contraction, Reflex, Abnormal.
Abstract
Trigemino-cervical reflexes (TCRs) are multisynaptic neck muscle withdrawal responses that are clearly identifiable in humans. Mediated by neural circuits at brainstem level, these reflex responses have been found to be significantly impaired in patients with Parkinson's disease (PD), and it has been hypothesized that a degeneration of brainstem neural structures could play a role in these abnormalities. Because extensive neuronal degeneration at brainstem level has been demonstrated in progressive supranuclear palsy (PSP), in this pilot study we evaluated the TCR responses in 12 subjects with PSP, and in 16 healthy controls. The TCRs were absent in 11 out of the 12 PSP patients while clear responses were evoked in all the healthy subjects. These findings indicate that PSP patients are unable to react to the painful stimuli to the face, suggesting a generalized impairment of the brainstem circuits mediating TCRs.
DOI: 10.1002/mds.22039
PubMed: 18561341
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lack of trigemino-cervical reflexes in progressive supranuclear palsy.</title><author><name sortKey="Bartolo, Michelangelo" sort="Bartolo, Michelangelo" uniqKey="Bartolo M" first="Michelangelo" last="Bartolo">Michelangelo Bartolo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, University of Pavia, Pavia, Italy. michelangelo.bartolo@mondino.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Serrao, Mariano" sort="Serrao, Mariano" uniqKey="Serrao M" first="Mariano" last="Serrao">Mariano Serrao</name></author><author><name sortKey="Perrotta, Armando" sort="Perrotta, Armando" uniqKey="Perrotta A" first="Armando" last="Perrotta">Armando Perrotta</name></author><author><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name></author><author><name sortKey="Sandrini, Giorgio" sort="Sandrini, Giorgio" uniqKey="Sandrini G" first="Giorgio" last="Sandrini">Giorgio Sandrini</name></author><author><name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22039</idno><idno type="RBID">pubmed:18561341</idno><idno type="pmid">18561341</idno><idno type="wicri:Area/PubMed/Corpus">002177</idno><idno type="wicri:Area/PubMed/Curation">002177</idno><idno type="wicri:Area/PubMed/Checkpoint">002245</idno><idno type="wicri:Area/Ncbi/Merge">002186</idno><idno type="wicri:Area/Ncbi/Curation">002186</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lack of trigemino-cervical reflexes in progressive supranuclear palsy.</title><author><name sortKey="Bartolo, Michelangelo" sort="Bartolo, Michelangelo" uniqKey="Bartolo M" first="Michelangelo" last="Bartolo">Michelangelo Bartolo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, University of Pavia, Pavia, Italy. michelangelo.bartolo@mondino.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Serrao, Mariano" sort="Serrao, Mariano" uniqKey="Serrao M" first="Mariano" last="Serrao">Mariano Serrao</name></author><author><name sortKey="Perrotta, Armando" sort="Perrotta, Armando" uniqKey="Perrotta A" first="Armando" last="Perrotta">Armando Perrotta</name></author><author><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name></author><author><name sortKey="Sandrini, Giorgio" sort="Sandrini, Giorgio" uniqKey="Sandrini G" first="Giorgio" last="Sandrini">Giorgio Sandrini</name></author><author><name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Stem (physiopathology)</term><term>Electric Stimulation</term><term>Electromyography</term><term>Female</term><term>Head Movements (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Neurons (physiology)</term><term>Muscle Contraction</term><term>Neck Muscles (innervation)</term><term>Neck Muscles (physiopathology)</term><term>Neural Pathways (physiopathology)</term><term>Reflex, Abnormal</term><term>Spinal Cord (physiopathology)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Trigeminal Nerve (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Neck Muscles</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Head Movements</term><term>Motor Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Stem</term><term>Neck Muscles</term><term>Neural Pathways</term><term>Spinal Cord</term><term>Supranuclear Palsy, Progressive</term><term>Trigeminal Nerve</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electric Stimulation</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscle Contraction</term><term>Reflex, Abnormal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Trigemino-cervical reflexes (TCRs) are multisynaptic neck muscle withdrawal responses that are clearly identifiable in humans. Mediated by neural circuits at brainstem level, these reflex responses have been found to be significantly impaired in patients with Parkinson's disease (PD), and it has been hypothesized that a degeneration of brainstem neural structures could play a role in these abnormalities. Because extensive neuronal degeneration at brainstem level has been demonstrated in progressive supranuclear palsy (PSP), in this pilot study we evaluated the TCR responses in 12 subjects with PSP, and in 16 healthy controls. The TCRs were absent in 11 out of the 12 PSP patients while clear responses were evoked in all the healthy subjects. These findings indicate that PSP patients are unable to react to the painful stimuli to the face, suggesting a generalized impairment of the brainstem circuits mediating TCRs.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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