MovDisordV3, Ncbi, Curation, bibRecord, 002116

Multiregional brain iron deficiency in restless legs syndrome.

Identifieur interne : 002116 ( Ncbi/Curation ); précédent : 002115; suivant : 002117

Multiregional brain iron deficiency in restless legs syndrome.

Auteurs : Jana Godau [Allemagne] ; Uwe Klose ; Adriana Di Santo ; Katherine Schweitzer ; Daniela Berg

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:18442125

English descriptors

KwdEn :
- Aged, Brain (pathology), Echoencephalography, Female, Ferritins (blood), Humans, Iron (deficiency), Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Restless Legs Syndrome (pathology), Substantia Nigra (pathology).
MESH :
- chemical , blood : Ferritins.
- chemical , deficiency : Iron.
- pathology : Brain, Restless Legs Syndrome, Substantia Nigra.
- Aged, Echoencephalography, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values.

Abstract

Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. (c) 2008 Movement Disorder Society.

DOI: 10.1002/mds.22070
PubMed: 18442125

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Le document en format XML

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<author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name>
<affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen, Germany. jana.godau@medizin.uni-tuebingen.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
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<author><name sortKey="Klose, Uwe" sort="Klose, Uwe" uniqKey="Klose U" first="Uwe" last="Klose">Uwe Klose</name>
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<author><name sortKey="Di Santo, Adriana" sort="Di Santo, Adriana" uniqKey="Di Santo A" first="Adriana" last="Di Santo">Adriana Di Santo</name>
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<author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name>
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<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Multiregional brain iron deficiency in restless legs syndrome.</title>
<author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name>
<affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen, Germany. jana.godau@medizin.uni-tuebingen.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
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<settlement type="city">Tübingen</settlement>
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<author><name sortKey="Klose, Uwe" sort="Klose, Uwe" uniqKey="Klose U" first="Uwe" last="Klose">Uwe Klose</name>
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<author><name sortKey="Di Santo, Adriana" sort="Di Santo, Adriana" uniqKey="Di Santo A" first="Adriana" last="Di Santo">Adriana Di Santo</name>
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<author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name>
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<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
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<term>Brain (pathology)</term>
<term>Echoencephalography</term>
<term>Female</term>
<term>Ferritins (blood)</term>
<term>Humans</term>
<term>Iron (deficiency)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
<term>Restless Legs Syndrome (pathology)</term>
<term>Substantia Nigra (pathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ferritins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Iron</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Restless Legs Syndrome</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Echoencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
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<front><div type="abstract" xml:lang="en">Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. (c) 2008 Movement Disorder Society.</div>
</front>
</TEI>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Multiregional brain iron deficiency in restless legs syndrome.

Multiregional brain iron deficiency in restless legs syndrome.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki