Multiregional brain iron deficiency in restless legs syndrome.
Identifieur interne : 002116 ( Ncbi/Curation ); précédent : 002115; suivant : 002117Multiregional brain iron deficiency in restless legs syndrome.
Auteurs : Jana Godau [Allemagne] ; Uwe Klose ; Adriana Di Santo ; Katherine Schweitzer ; Daniela BergSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Ferritins.
- chemical , deficiency : Iron.
- pathology : Brain, Restless Legs Syndrome, Substantia Nigra.
- Aged, Echoencephalography, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values.
Abstract
Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. (c) 2008 Movement Disorder Society.
DOI: 10.1002/mds.22070
PubMed: 18442125
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pubmed:18442125Le document en format XML
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<author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name>
<affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen, Germany. jana.godau@medizin.uni-tuebingen.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
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<author><name sortKey="Klose, Uwe" sort="Klose, Uwe" uniqKey="Klose U" first="Uwe" last="Klose">Uwe Klose</name>
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<author><name sortKey="Di Santo, Adriana" sort="Di Santo, Adriana" uniqKey="Di Santo A" first="Adriana" last="Di Santo">Adriana Di Santo</name>
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<author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name>
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<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
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<affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen, Germany. jana.godau@medizin.uni-tuebingen.de</nlm:affiliation>
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<author><name sortKey="Klose, Uwe" sort="Klose, Uwe" uniqKey="Klose U" first="Uwe" last="Klose">Uwe Klose</name>
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<author><name sortKey="Di Santo, Adriana" sort="Di Santo, Adriana" uniqKey="Di Santo A" first="Adriana" last="Di Santo">Adriana Di Santo</name>
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<author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Brain (pathology)</term>
<term>Echoencephalography</term>
<term>Female</term>
<term>Ferritins (blood)</term>
<term>Humans</term>
<term>Iron (deficiency)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
<term>Restless Legs Syndrome (pathology)</term>
<term>Substantia Nigra (pathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ferritins</term>
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<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Iron</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Restless Legs Syndrome</term>
<term>Substantia Nigra</term>
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<term>Echoencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
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<front><div type="abstract" xml:lang="en">Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. (c) 2008 Movement Disorder Society.</div>
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