Amantadine may reverse punding in Parkinson's disease--observation in a patient.
Identifieur interne : 001E79 ( Ncbi/Curation ); précédent : 001E78; suivant : 001E80Amantadine may reverse punding in Parkinson's disease--observation in a patient.
Auteurs : Kenichi Kashihara [Japon] ; Takaki ImamuraSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Amantadine, Dopamine Agents.
- complications : Parkinson Disease, Stereotypic Movement Disorder.
- drug therapy : Stereotypic Movement Disorder.
- Aged, Drug Administration Schedule, Female, Humans.
Abstract
Punding, complex stereotyped behavior, sometimes occurs in patients with Parkinson's disease under dopaminergic replacement therapy. Reduction of dopaminergic drugs may reduce the problem but risks enhancing motor impairment. We report a patient with Parkinson's disease presenting disabling punding, which was reversed by amantadine without aggravating motor function. Amantadine may reduce punding by blocking NMDA receptors, in the same manner as in levodopa-induced dyskinesias.
DOI: 10.1002/mds.21780
PubMed: 17960816
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pubmed:17960816Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Amantadine may reverse punding in Parkinson's disease--observation in a patient.</title>
<author><name sortKey="Kashihara, Kenichi" sort="Kashihara, Kenichi" uniqKey="Kashihara K" first="Kenichi" last="Kashihara">Kenichi Kashihara</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Okayama Kyokuto Hospital, Kurata, Okayama, Japan. kkashi@kyokuto.or.jp</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Okayama Kyokuto Hospital, Kurata, Okayama</wicri:regionArea>
<wicri:noRegion>Okayama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Imamura, Takaki" sort="Imamura, Takaki" uniqKey="Imamura T" first="Takaki" last="Imamura">Takaki Imamura</name>
</author>
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<idno type="doi">10.1002/mds.21780</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Amantadine may reverse punding in Parkinson's disease--observation in a patient.</title>
<author><name sortKey="Kashihara, Kenichi" sort="Kashihara, Kenichi" uniqKey="Kashihara K" first="Kenichi" last="Kashihara">Kenichi Kashihara</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Okayama Kyokuto Hospital, Kurata, Okayama, Japan. kkashi@kyokuto.or.jp</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Okayama Kyokuto Hospital, Kurata, Okayama</wicri:regionArea>
<wicri:noRegion>Okayama</wicri:noRegion>
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<author><name sortKey="Imamura, Takaki" sort="Imamura, Takaki" uniqKey="Imamura T" first="Takaki" last="Imamura">Takaki Imamura</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Amantadine (therapeutic use)</term>
<term>Dopamine Agents (therapeutic use)</term>
<term>Drug Administration Schedule</term>
<term>Female</term>
<term>Humans</term>
<term>Parkinson Disease (complications)</term>
<term>Stereotypic Movement Disorder (complications)</term>
<term>Stereotypic Movement Disorder (drug therapy)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amantadine</term>
<term>Dopamine Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
<term>Stereotypic Movement Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stereotypic Movement Disorder</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Drug Administration Schedule</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Punding, complex stereotyped behavior, sometimes occurs in patients with Parkinson's disease under dopaminergic replacement therapy. Reduction of dopaminergic drugs may reduce the problem but risks enhancing motor impairment. We report a patient with Parkinson's disease presenting disabling punding, which was reversed by amantadine without aggravating motor function. Amantadine may reduce punding by blocking NMDA receptors, in the same manner as in levodopa-induced dyskinesias.</div>
</front>
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