Amantadine may reverse punding in Parkinson's disease--observation in a patient.
Identifieur interne : 001E79 ( Ncbi/Curation ); précédent : 001E78; suivant : 001E80Amantadine may reverse punding in Parkinson's disease--observation in a patient.
Auteurs : Kenichi Kashihara [Japon] ; Takaki ImamuraSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Amantadine, Dopamine Agents.
- complications : Parkinson Disease, Stereotypic Movement Disorder.
- drug therapy : Stereotypic Movement Disorder.
- Aged, Drug Administration Schedule, Female, Humans.
Abstract
Punding, complex stereotyped behavior, sometimes occurs in patients with Parkinson's disease under dopaminergic replacement therapy. Reduction of dopaminergic drugs may reduce the problem but risks enhancing motor impairment. We report a patient with Parkinson's disease presenting disabling punding, which was reversed by amantadine without aggravating motor function. Amantadine may reduce punding by blocking NMDA receptors, in the same manner as in levodopa-induced dyskinesias.
DOI: 10.1002/mds.21780
PubMed: 17960816
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