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A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis.

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A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis.

Auteurs : Peter Valkovic [Slovaquie] ; Georgi Krastev ; Miroslav Mako ; Petra Leitner ; Thomas Gasser

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.

RBID : pubmed:17914725

English descriptors

KwdEn :
- Adult, Age of Onset, Demyelinating Diseases (complications), Demyelinating Diseases (pathology), Humans, Magnetic Resonance Imaging, Male, Multiple Sclerosis (complications), Multiple Sclerosis (pathology), Parkinson Disease (complications), Parkinson Disease (pathology).
MESH :
- complications : Demyelinating Diseases, Multiple Sclerosis, Parkinson Disease.
- pathology : Demyelinating Diseases, Multiple Sclerosis, Parkinson Disease.
- Adult, Age of Onset, Humans, Magnetic Resonance Imaging, Male.

Abstract

We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to trihexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug-induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30.

DOI: 10.1002/mds.21642
PubMed: 17914725

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Le document en format XML

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<author><name sortKey="Valkovic, Peter" sort="Valkovic, Peter" uniqKey="Valkovic P" first="Peter" last="Valkovic">Peter Valkovic</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Trnavian University Hospital, Trnava, Slovakia. peter.valkovic@gmail.com</nlm:affiliation>
<country xml:lang="fr">Slovaquie</country>
<wicri:regionArea>Department of Neurology, Trnavian University Hospital, Trnava</wicri:regionArea>
<wicri:noRegion>Trnava</wicri:noRegion>
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<author><name sortKey="Krastev, Georgi" sort="Krastev, Georgi" uniqKey="Krastev G" first="Georgi" last="Krastev">Georgi Krastev</name>
</author>
<author><name sortKey="Mako, Miroslav" sort="Mako, Miroslav" uniqKey="Mako M" first="Miroslav" last="Mako">Miroslav Mako</name>
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<author><name sortKey="Leitner, Petra" sort="Leitner, Petra" uniqKey="Leitner P" first="Petra" last="Leitner">Petra Leitner</name>
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<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis.</title>
<author><name sortKey="Valkovic, Peter" sort="Valkovic, Peter" uniqKey="Valkovic P" first="Peter" last="Valkovic">Peter Valkovic</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Trnavian University Hospital, Trnava, Slovakia. peter.valkovic@gmail.com</nlm:affiliation>
<country xml:lang="fr">Slovaquie</country>
<wicri:regionArea>Department of Neurology, Trnavian University Hospital, Trnava</wicri:regionArea>
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<author><name sortKey="Krastev, Georgi" sort="Krastev, Georgi" uniqKey="Krastev G" first="Georgi" last="Krastev">Georgi Krastev</name>
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<author><name sortKey="Mako, Miroslav" sort="Mako, Miroslav" uniqKey="Mako M" first="Miroslav" last="Mako">Miroslav Mako</name>
</author>
<author><name sortKey="Leitner, Petra" sort="Leitner, Petra" uniqKey="Leitner P" first="Petra" last="Leitner">Petra Leitner</name>
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<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<imprint><date when="2007" type="published">2007</date>
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<term>Age of Onset</term>
<term>Demyelinating Diseases (complications)</term>
<term>Demyelinating Diseases (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Multiple Sclerosis (complications)</term>
<term>Multiple Sclerosis (pathology)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Demyelinating Diseases</term>
<term>Multiple Sclerosis</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Demyelinating Diseases</term>
<term>Multiple Sclerosis</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to trihexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug-induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30.</div>
</front>
</TEI>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis.

A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis.

Source :

English descriptors

Abstract

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Le document en format XML

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