Skin vasodilator response to local heating in multiple system atrophy.
Identifieur interne : 001E50 ( Ncbi/Curation ); précédent : 001E49; suivant : 001E51Skin vasodilator response to local heating in multiple system atrophy.
Auteurs : Yoshitaka Yamanaka [Japon] ; Masato Asahina ; Christopher J. Mathias ; Yuichi Akaogi ; Yu Koyama ; Takamichi HattoriSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Aged, Autonomic Nervous System (physiology), Data Interpretation, Statistical, Female, Hand (blood supply), Hot Temperature, Humans, Laser-Doppler Flowmetry, Male, Middle Aged, Multiple System Atrophy (physiopathology), Posture (physiology), Regional Blood Flow (physiology), Skin (blood supply), Vasodilation (physiology).
- MESH :
- blood supply : Hand, Skin.
- physiology : Autonomic Nervous System, Posture, Regional Blood Flow, Vasodilation.
- physiopathology : Multiple System Atrophy.
- Aged, Data Interpretation, Statistical, Female, Hot Temperature, Humans, Laser-Doppler Flowmetry, Male, Middle Aged.
Abstract
Local heating of nonglabrous skin increases skin blood flow (SkBF) in two phases. The initial peak (P1) is mediated by a sensory-axon reflex and the plateau phase (P2) by local production of substances such as nitric oxide. We evaluated the SkBF response to local heating in 15 multiple system atrophy (MSA) patients with autonomic failure and 12 age-matched healthy controls. The mean ratio of SkBF at P1 to that at baseline (SkBF(P1)/SkBF(base) ratio) in MSA was significantly lower than that in controls (P < 0.01). The mean ratio of SkBF at P2 seemed to be slightly reduced in the MSA patients, compared with controls, although there was no significant difference. The P1 phase is thought to be mediated by a sensory-axon reflex modulated by sympathetic nerve activity. These findings are indicative of the skin sympathetic vasomotor dysfunction in MSA.
DOI: 10.1002/mds.21742
PubMed: 17894341
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pubmed:17894341Le document en format XML
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<author><name sortKey="Yamanaka, Yoshitaka" sort="Yamanaka, Yoshitaka" uniqKey="Yamanaka Y" first="Yoshitaka" last="Yamanaka">Yoshitaka Yamanaka</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan. y-yama@jk9.so-net.ne.jp</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Chiba University Graduate School of Medicine, Chiba</wicri:regionArea>
<wicri:noRegion>Chiba</wicri:noRegion>
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</author>
<author><name sortKey="Asahina, Masato" sort="Asahina, Masato" uniqKey="Asahina M" first="Masato" last="Asahina">Masato Asahina</name>
</author>
<author><name sortKey="Mathias, Christopher J" sort="Mathias, Christopher J" uniqKey="Mathias C" first="Christopher J" last="Mathias">Christopher J. Mathias</name>
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<author><name sortKey="Akaogi, Yuichi" sort="Akaogi, Yuichi" uniqKey="Akaogi Y" first="Yuichi" last="Akaogi">Yuichi Akaogi</name>
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<author><name sortKey="Koyama, Yu" sort="Koyama, Yu" uniqKey="Koyama Y" first="Yu" last="Koyama">Yu Koyama</name>
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<author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Skin vasodilator response to local heating in multiple system atrophy.</title>
<author><name sortKey="Yamanaka, Yoshitaka" sort="Yamanaka, Yoshitaka" uniqKey="Yamanaka Y" first="Yoshitaka" last="Yamanaka">Yoshitaka Yamanaka</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan. y-yama@jk9.so-net.ne.jp</nlm:affiliation>
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<wicri:regionArea>Department of Neurology, Chiba University Graduate School of Medicine, Chiba</wicri:regionArea>
<wicri:noRegion>Chiba</wicri:noRegion>
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<author><name sortKey="Asahina, Masato" sort="Asahina, Masato" uniqKey="Asahina M" first="Masato" last="Asahina">Masato Asahina</name>
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<author><name sortKey="Mathias, Christopher J" sort="Mathias, Christopher J" uniqKey="Mathias C" first="Christopher J" last="Mathias">Christopher J. Mathias</name>
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<author><name sortKey="Akaogi, Yuichi" sort="Akaogi, Yuichi" uniqKey="Akaogi Y" first="Yuichi" last="Akaogi">Yuichi Akaogi</name>
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<author><name sortKey="Koyama, Yu" sort="Koyama, Yu" uniqKey="Koyama Y" first="Yu" last="Koyama">Yu Koyama</name>
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<author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007" type="published">2007</date>
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<term>Autonomic Nervous System (physiology)</term>
<term>Data Interpretation, Statistical</term>
<term>Female</term>
<term>Hand (blood supply)</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Laser-Doppler Flowmetry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (physiopathology)</term>
<term>Posture (physiology)</term>
<term>Regional Blood Flow (physiology)</term>
<term>Skin (blood supply)</term>
<term>Vasodilation (physiology)</term>
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<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Hand</term>
<term>Skin</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autonomic Nervous System</term>
<term>Posture</term>
<term>Regional Blood Flow</term>
<term>Vasodilation</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Multiple System Atrophy</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Data Interpretation, Statistical</term>
<term>Female</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Laser-Doppler Flowmetry</term>
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<front><div type="abstract" xml:lang="en">Local heating of nonglabrous skin increases skin blood flow (SkBF) in two phases. The initial peak (P1) is mediated by a sensory-axon reflex and the plateau phase (P2) by local production of substances such as nitric oxide. We evaluated the SkBF response to local heating in 15 multiple system atrophy (MSA) patients with autonomic failure and 12 age-matched healthy controls. The mean ratio of SkBF at P1 to that at baseline (SkBF(P1)/SkBF(base) ratio) in MSA was significantly lower than that in controls (P < 0.01). The mean ratio of SkBF at P2 seemed to be slightly reduced in the MSA patients, compared with controls, although there was no significant difference. The P1 phase is thought to be mediated by a sensory-axon reflex modulated by sympathetic nerve activity. These findings are indicative of the skin sympathetic vasomotor dysfunction in MSA.</div>
</front>
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</record>
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