Long lasting pure freezing of gait preceding progressive supranuclear palsy: a clinicopathological study.
Identifieur interne : 001E23 ( Ncbi/Curation ); précédent : 001E22; suivant : 001E24Long lasting pure freezing of gait preceding progressive supranuclear palsy: a clinicopathological study.
Auteurs : Yaroslau Compta [Espagne] ; Francesc Valldeoriola ; Eduardo Tolosa ; María Jesús Rey ; María José Martí ; Josep Valls-SoléSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Accidental Falls, Aged, Astrocytes (pathology), Brain (pathology), Diagnosis, Differential, Disease Progression, Dopamine Plasma Membrane Transport Proteins (physiology), Female, Gait Disorders, Neurologic (diagnosis), Gait Disorders, Neurologic (pathology), Humans, Inclusion Bodies (pathology), Iodine Radioisotopes (diagnostic use), Magnetic Resonance Imaging, Neurofibrillary Tangles (pathology), Neurologic Examination, Neuropil (pathology), Nortropanes (diagnostic use), Oligodendroglia (pathology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (pathology), Tauopathies (diagnosis), Tauopathies (pathology), Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes, Nortropanes.
- chemical , physiology : Dopamine Plasma Membrane Transport Proteins.
- diagnosis : Gait Disorders, Neurologic, Supranuclear Palsy, Progressive, Tauopathies.
- pathology : Astrocytes, Brain, Gait Disorders, Neurologic, Inclusion Bodies, Neurofibrillary Tangles, Neuropil, Oligodendroglia, Supranuclear Palsy, Progressive, Tauopathies.
- Accidental Falls, Aged, Diagnosis, Differential, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Neurologic Examination, Tomography, Emission-Computed, Single-Photon.
Abstract
Primary progressive freezing of gait (PPFG) is the term used to designate an uncommon condition featuring freezing of gait with frequent falls, without bradykinesia, rigidity or tremor, and unresponsive to levodopa. There are very few pathological reports of patients with PPFG in the literature. We report on 2 patients (one with pathological confirmation) diagnosed initially as PPFG and evolving into clinically defined progressive supranuclear palsy (PSP) more than 10 years after onset of symptoms. These 2 cases suggest that PPFG can represent the initial manifestation of a neurodegenerative disease, such as PSP, rather than a differentiated nosological entity.
DOI: 10.1002/mds.21612
PubMed: 17724746
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last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Rey, Maria Jesus" sort="Rey, Maria Jesus" uniqKey="Rey M" first="María Jesús" last="Rey">María Jesús Rey</name></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="María José" last="Martí">María José Martí</name></author><author><name sortKey="Valls Sole, Josep" sort="Valls Sole, Josep" uniqKey="Valls Sole J" first="Josep" last="Valls-Solé">Josep Valls-Solé</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21612</idno><idno type="RBID">pubmed:17724746</idno><idno type="pmid">17724746</idno><idno type="wicri:Area/PubMed/Corpus">002536</idno><idno type="wicri:Area/PubMed/Curation">002536</idno><idno 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Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Rey, Maria Jesus" sort="Rey, Maria Jesus" uniqKey="Rey M" first="María Jesús" last="Rey">María Jesús Rey</name></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="María José" last="Martí">María José Martí</name></author><author><name sortKey="Valls Sole, Josep" sort="Valls Sole, Josep" uniqKey="Valls Sole J" first="Josep" last="Valls-Solé">Josep Valls-Solé</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno 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Progressive (pathology)</term><term>Tauopathies (diagnosis)</term><term>Tauopathies (pathology)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Iodine Radioisotopes</term><term>Nortropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Supranuclear Palsy, Progressive</term><term>Tauopathies</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Astrocytes</term><term>Brain</term><term>Gait Disorders, Neurologic</term><term>Inclusion Bodies</term><term>Neurofibrillary Tangles</term><term>Neuropil</term><term>Oligodendroglia</term><term>Supranuclear Palsy, Progressive</term><term>Tauopathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Accidental Falls</term><term>Aged</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Neurologic Examination</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary progressive freezing of gait (PPFG) is the term used to designate an uncommon condition featuring freezing of gait with frequent falls, without bradykinesia, rigidity or tremor, and unresponsive to levodopa. There are very few pathological reports of patients with PPFG in the literature. We report on 2 patients (one with pathological confirmation) diagnosed initially as PPFG and evolving into clinically defined progressive supranuclear palsy (PSP) more than 10 years after onset of symptoms. These 2 cases suggest that PPFG can represent the initial manifestation of a neurodegenerative disease, such as PSP, rather than a differentiated nosological entity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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