Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy.
Identifieur interne : 001D82 ( Ncbi/Curation ); précédent : 001D81; suivant : 001D83Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy.
Auteurs : Jose Enrique Martinez-Rodriguez [Espagne] ; Klaus Seppi ; Adriana Cardozo ; Alex Iranzo ; Michaela Stampfer-Kountchev ; Gregor Wenning ; Eduardo Tolosa ; Birgit Högl ; Joan Santamaria ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , cerebrospinal fluid : Intracellular Signaling Peptides and Proteins, Neuropeptides.
- cerebrospinal fluid : Multiple System Atrophy.
- physiopathology : Multiple System Atrophy.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin-1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease.
DOI: 10.1002/mds.21668
PubMed: 17659646
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pubmed:17659646Le document en format XML
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sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></author><author><name sortKey="Cardozo, Adriana" sort="Cardozo, Adriana" uniqKey="Cardozo A" first="Adriana" last="Cardozo">Adriana Cardozo</name></author><author><name sortKey="Iranzo, Alex" sort="Iranzo, Alex" uniqKey="Iranzo A" first="Alex" last="Iranzo">Alex Iranzo</name></author><author><name sortKey="Stampfer Kountchev, Michaela" sort="Stampfer Kountchev, Michaela" uniqKey="Stampfer Kountchev M" first="Michaela" last="Stampfer-Kountchev">Michaela Stampfer-Kountchev</name></author><author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit 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xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Intracellular Signaling Peptides and Proteins (cerebrospinal fluid)</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (cerebrospinal fluid)</term><term>Multiple System Atrophy (physiopathology)</term><term>Neuropeptides (cerebrospinal fluid)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Neuropeptides</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin-1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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