Deep brain stimulation in Tourette's syndrome.
Identifieur interne : 001D16 ( Ncbi/Curation ); précédent : 001D15; suivant : 001D17Deep brain stimulation in Tourette's syndrome.
Auteurs : Rizma Jalees Bajwa [États-Unis] ; Alain J. De Lotbinière ; Robert A. King ; Bahman Jabbari ; Susan Quatrano ; Kimberly Kunze ; Lawrence Scahill ; James F. LeckmanSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- methods : Deep Brain Stimulation.
- therapy : Tourette Syndrome.
- Humans, Male, Middle Aged.
Abstract
A 48-year-old man with severe, lifelong Tourette's syndrome (TS) characterized by forceful self-injurious motor tics and obsessive-compulsive disorder was treated with bilateral deep brain stimulation (DBS). The decision to treat was based on his progressive neurological impairment (left sided weakness secondary to spinal cord injury) because of his relentless, violent head jerks. Electrodes were implanted at the level of the medial part of the thalamus (centromedian nucleus, the substantia periventricularis, and the nucleus ventro-oralis internus). DBS resulted in a substantial reduction of tics. These data show that bilateral DBS of the thalamus can have a good effect on severe tics in adult patients suffering from intractable TS.
DOI: 10.1002/mds.21398
PubMed: 17580320
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pubmed:17580320Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
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<author><name sortKey="De Lotbiniere, Alain J" sort="De Lotbiniere, Alain J" uniqKey="De Lotbiniere A" first="Alain J" last="De Lotbinière">Alain J. De Lotbinière</name>
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<author><name sortKey="King, Robert A" sort="King, Robert A" uniqKey="King R" first="Robert A" last="King">Robert A. King</name>
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<author><name sortKey="Jabbari, Bahman" sort="Jabbari, Bahman" uniqKey="Jabbari B" first="Bahman" last="Jabbari">Bahman Jabbari</name>
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<author><name sortKey="Quatrano, Susan" sort="Quatrano, Susan" uniqKey="Quatrano S" first="Susan" last="Quatrano">Susan Quatrano</name>
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<author><name sortKey="Kunze, Kimberly" sort="Kunze, Kimberly" uniqKey="Kunze K" first="Kimberly" last="Kunze">Kimberly Kunze</name>
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<author><name sortKey="Scahill, Lawrence" sort="Scahill, Lawrence" uniqKey="Scahill L" first="Lawrence" last="Scahill">Lawrence Scahill</name>
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<front><div type="abstract" xml:lang="en">A 48-year-old man with severe, lifelong Tourette's syndrome (TS) characterized by forceful self-injurious motor tics and obsessive-compulsive disorder was treated with bilateral deep brain stimulation (DBS). The decision to treat was based on his progressive neurological impairment (left sided weakness secondary to spinal cord injury) because of his relentless, violent head jerks. Electrodes were implanted at the level of the medial part of the thalamus (centromedian nucleus, the substantia periventricularis, and the nucleus ventro-oralis internus). DBS resulted in a substantial reduction of tics. These data show that bilateral DBS of the thalamus can have a good effect on severe tics in adult patients suffering from intractable TS.</div>
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