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An open trial of levetiracetam for segmental and generalized dystonia.

Identifieur interne : 001C95 ( Ncbi/Curation ); précédent : 001C94; suivant : 001C96

An open trial of levetiracetam for segmental and generalized dystonia.

Auteurs : Sascha Hering [Autriche] ; Gregor K. Wenning ; Klaus Seppi ; Werner Poewe [Autriche] ; Joerg Mueller

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.

RBID : pubmed:17557353

English descriptors

KwdEn :
- Adult, Aged, Anticonvulsants (therapeutic use), Dystonia (classification), Dystonia (drug therapy), Female, Follow-Up Studies, Humans, Male, Middle Aged, Piracetam (analogs & derivatives), Piracetam (therapeutic use), Treatment Outcome.
MESH :
- chemical , analogs & derivatives : Piracetam.
- chemical , therapeutic use : Anticonvulsants, Piracetam.
- classification : Dystonia.
- drug therapy : Dystonia.
- Adult, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome.

Abstract

Local botulinum toxin injections represent the treatment of choice for most patients with focal dystonia. However, patients with segmental or generalized forms require additional pharmacologic treatment which is often ineffective or limited by intolerable side-effects. An animal study and three case reports suggested antidystonic effects of levetiracetam, a pyrrolidone derivate, whereas a recent open-label study found no improvement in 10 patients with primary idiopathic cervical dystonia. We studied the efficacy of levetiracetam in a daily dose of 3000 mg in 10 consecutive patients with otherwise therapy refractory segmental or generalized dystonia. At 4-week follow-up, none of the patients showed improvement of dystonia, mild side-effects were observed in 3 patients.

DOI: 10.1002/mds.21597
PubMed: 17557353

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pubmed:17557353

Le document en format XML

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<author><name sortKey="Hering, Sascha" sort="Hering, Sascha" uniqKey="Hering S" first="Sascha" last="Hering">Sascha Hering</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Medical University Innsbruck, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Innsbruck</wicri:regionArea>
<wicri:noRegion>Medical University Innsbruck</wicri:noRegion>
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<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
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<orgName type="university">Université de médecine d'Innsbruck</orgName>
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<author><name sortKey="Mueller, Joerg" sort="Mueller, Joerg" uniqKey="Mueller J" first="Joerg" last="Mueller">Joerg Mueller</name>
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<idno type="doi">10.1002/mds.21597</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">An open trial of levetiracetam for segmental and generalized dystonia.</title>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Medical University Innsbruck, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Innsbruck</wicri:regionArea>
<wicri:noRegion>Medical University Innsbruck</wicri:noRegion>
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<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name>
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<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
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<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007" type="published">2007</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Anticonvulsants (therapeutic use)</term>
<term>Dystonia (classification)</term>
<term>Dystonia (drug therapy)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Piracetam (analogs & derivatives)</term>
<term>Piracetam (therapeutic use)</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Piracetam</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticonvulsants</term>
<term>Piracetam</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Dystonia</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">Local botulinum toxin injections represent the treatment of choice for most patients with focal dystonia. However, patients with segmental or generalized forms require additional pharmacologic treatment which is often ineffective or limited by intolerable side-effects. An animal study and three case reports suggested antidystonic effects of levetiracetam, a pyrrolidone derivate, whereas a recent open-label study found no improvement in 10 patients with primary idiopathic cervical dystonia. We studied the efficacy of levetiracetam in a daily dose of 3000 mg in 10 consecutive patients with otherwise therapy refractory segmental or generalized dystonia. At 4-week follow-up, none of the patients showed improvement of dystonia, mild side-effects were observed in 3 patients.</div>
</front>
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	Movement Disorders (revue)
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Movement Disorders (revue)

An open trial of levetiracetam for segmental and generalized dystonia.

An open trial of levetiracetam for segmental and generalized dystonia.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki