Analysis of olfactory function and the depth of olfactory sulcus in patients with Parkinson's disease.
Identifieur interne : 001C58 ( Ncbi/Curation ); précédent : 001C57; suivant : 001C59Analysis of olfactory function and the depth of olfactory sulcus in patients with Parkinson's disease.
Auteurs : Ji Youn Kim [Corée du Sud] ; Won Yong Lee ; Eun Joo Chung ; Hun-Jong DhongSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Olfaction Disorders.
- pathology : Parkinson Disease.
- physiology : Discrimination (Psychology), Smell.
- physiopathology : Olfactory Bulb.
- Aged, Chi-Square Distribution, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Olfactory deficit is known to occur frequently in Parkinson's disease (PD). This study aimed to explore olfactory deficit in PD and to investigate its possible correlation with the disease severity or the depth of the olfactory sulcus. Fifty-nine PD patients and 25 normal controls were examined by the odor identification test with the crosscultural smell identification test (CC-SIT). Among these subjects, the depth of the olfactory sulcus of 42 PD patients and 8 controls was measured in the plane of the posterior tangent through the eyeballs using the coronal view brain MRI. The CC-SIT scores of the PD patients were significantly lower than those of the normal control (P<0.001). However, CC-SIT did not correlate with the disease duration, H-Y stage, score of UPDRS Part III, or the depth of either side of the olfactory sulcus (P>0.05). Our study confirms that CC-SIT is a helpful test in detecting the olfactory deficit in Korean PD patients. The absence of correlation of olfactory deficit with the disease severity or the depth of olfactory sulcus may suggest that olfactory loss precede the development of motor signs and not be a primary consequence of damage to the olfactory sulcus.
DOI: 10.1002/mds.21490
PubMed: 17534948
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pubmed:17534948Le document en format XML
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This study aimed to explore olfactory deficit in PD and to investigate its possible correlation with the disease severity or the depth of the olfactory sulcus. Fifty-nine PD patients and 25 normal controls were examined by the odor identification test with the crosscultural smell identification test (CC-SIT). Among these subjects, the depth of the olfactory sulcus of 42 PD patients and 8 controls was measured in the plane of the posterior tangent through the eyeballs using the coronal view brain MRI. The CC-SIT scores of the PD patients were significantly lower than those of the normal control (P<0.001). However, CC-SIT did not correlate with the disease duration, H-Y stage, score of UPDRS Part III, or the depth of either side of the olfactory sulcus (P>0.05). Our study confirms that CC-SIT is a helpful test in detecting the olfactory deficit in Korean PD patients. The absence of correlation of olfactory deficit with the disease severity or the depth of olfactory sulcus may suggest that olfactory loss precede the development of motor signs and not be a primary consequence of damage to the olfactory sulcus.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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