Movement Disorders (revue)

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G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy.

Identifieur interne : 001A33 ( Ncbi/Curation ); précédent : 001A32; suivant : 001A34

G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy.

Auteurs : Laurie J. Ozelius [États-Unis] ; Tatiana Foroud ; Susanne May ; Geetha Senthil ; Paola Sandroni ; Phillip A. Low ; Stephen Reich ; Amy Colcher ; Matthew B. Stern ; William G. Ondo ; Joseph Jankovic [États-Unis] ; Neng Huang ; Caroline M. Tanner ; Peter Novak ; Sid Gilman ; Frederick J. Marshall ; G Frederick Wooten ; Thomas C. Chelimsky ; Clifford W. Shults

Source :

RBID : pubmed:17230458

English descriptors

Abstract

Multiple system atrophy (MSA) is characterized clinically by Parkinsonism, cerebellar dysfunction, and autonomic impairment. Multiple mutations in the LRRK2 gene are associated with parkinsonian disorders, and the most common one, the G2019S mutation, has been found in approximately 1% of sporadic cases of Parkinsonism. In a well-characterized cohort of 136 subjects with probable MSA and 110 neurologically evaluated control subjects, none carried the G2019S mutation. We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA.

DOI: 10.1002/mds.21343
PubMed: 17230458

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pubmed:17230458

Le document en format XML

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<term>Cerebellum (pathology)</term>
<term>Female</term>
<term>Gene Expression (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (epidemiology)</term>
<term>Multiple System Atrophy (pathology)</term>
<term>Parkinsonian Disorders (epidemiology)</term>
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<term>Parkinsonian Disorders</term>
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<term>Gene Expression</term>
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<div type="abstract" xml:lang="en">Multiple system atrophy (MSA) is characterized clinically by Parkinsonism, cerebellar dysfunction, and autonomic impairment. Multiple mutations in the LRRK2 gene are associated with parkinsonian disorders, and the most common one, the G2019S mutation, has been found in approximately 1% of sporadic cases of Parkinsonism. In a well-characterized cohort of 136 subjects with probable MSA and 110 neurologically evaluated control subjects, none carried the G2019S mutation. We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA.</div>
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