LRRK2 G2019S founder haplotype in the Chinese population.
Identifieur interne : 001933 ( Ncbi/Curation ); précédent : 001932; suivant : 001934LRRK2 G2019S founder haplotype in the Chinese population.
Auteurs : Eng-King Tan [Singapour] ; Lisa Skipper ; Louis Tan ; Jian-Jun LiuSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Glycine, Protein-Serine-Threonine Kinases, Serine.
- epidemiology : Parkinson Disease.
- ethnology : Asian Continental Ancestry Group.
- genetics : Parkinson Disease.
- Haplotypes, Humans.
Abstract
The G2019S mutation in the LRRK2 (leucine-rich repeat kinase) gene appears very rarely in the Chinese population. Among Chinese subjects who were non-G2019S carriers, we demonstrated the frequency of the LRRK2 G2019S founder haplotype (T-254-A-G-A-154) in Parkinson's disease and controls to be 33% and 30%. This rate is similar to the frequency in European noncarriers, indirectly supporting the association of this haplotype with G2019S carriers. The haplotype is likely to be more ancient than the G2019S mutation because it is also found in a population with a very low carrier rate.
DOI: 10.1002/mds.21206
PubMed: 17083102
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pubmed:17083102Le document en format XML
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