Impaired long-term potentiation-like plasticity of the trigeminal blink reflex circuit in Parkinson's disease.
Identifieur interne : 001905 ( Ncbi/Curation ); précédent : 001904; suivant : 001906Impaired long-term potentiation-like plasticity of the trigeminal blink reflex circuit in Parkinson's disease.
Auteurs : Fortunato Battaglia [États-Unis] ; Maria Felice Ghilardi ; Angelo Quartarone ; Sergio Bagnato ; Paolo Girlanda ; Mark HallettSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Blinking (physiology), Dose-Response Relationship, Radiation, Electric Stimulation (methods), Female, Functional Laterality, Humans, Long-Term Potentiation (physiology), Male, Middle Aged, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Reaction Time (physiology), Reaction Time (radiation effects), Trigeminal Nerve (physiopathology), Trigeminal Nerve (radiation effects).
- MESH :
- methods : Electric Stimulation.
- pathology : Parkinson Disease.
- physiology : Blinking, Long-Term Potentiation, Reaction Time.
- physiopathology : Parkinson Disease, Trigeminal Nerve.
- radiation effects : Reaction Time, Trigeminal Nerve.
- Aged, Analysis of Variance, Dose-Response Relationship, Radiation, Female, Functional Laterality, Humans, Male, Middle Aged.
Abstract
We investigated the hypothesis that Parkinsons's disease (PD) is associated with abnormal plasticity of the neuronal circuits mediating blink reflex. We induced long-term potentiation (LTP)-like plasticity in trigeminal wide dynamic range neurons of the blink reflex circuit by pairing an high-frequency train of electrical stimuli over the right supraorbital nerve (SO) coincident with the R2 response elicited by a preceding SO stimulus. The facilitation of the R2 response after the induction protocol was markedly decreased in patients relative to controls. Treatment with dopaminergic drugs normalized the LTP-like plasticity of the R2 response. We conclude that nigrostriatal denervation disrupts LTP-like plasticity in the trigeminal reflex circuit.
DOI: 10.1002/mds.21138
PubMed: 17078045
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uniqKey="Quartarone A" first="Angelo" last="Quartarone">Angelo Quartarone</name></author><author><name sortKey="Bagnato, Sergio" sort="Bagnato, Sergio" uniqKey="Bagnato S" first="Sergio" last="Bagnato">Sergio Bagnato</name></author><author><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.21138</idno><idno type="RBID">pubmed:17078045</idno><idno type="pmid">17078045</idno><idno type="wicri:Area/PubMed/Corpus">002A34</idno><idno type="wicri:Area/PubMed/Curation">002A34</idno><idno type="wicri:Area/PubMed/Checkpoint">002C78</idno><idno type="wicri:Area/Ncbi/Merge">001905</idno><idno 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sortKey="Quartarone, Angelo" sort="Quartarone, Angelo" uniqKey="Quartarone A" first="Angelo" last="Quartarone">Angelo Quartarone</name></author><author><name sortKey="Bagnato, Sergio" sort="Bagnato, Sergio" uniqKey="Bagnato S" first="Sergio" last="Bagnato">Sergio Bagnato</name></author><author><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Blinking (physiology)</term><term>Dose-Response Relationship, Radiation</term><term>Electric Stimulation (methods)</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Long-Term Potentiation (physiology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Reaction Time (physiology)</term><term>Reaction Time (radiation effects)</term><term>Trigeminal Nerve (physiopathology)</term><term>Trigeminal Nerve (radiation effects)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blinking</term><term>Long-Term Potentiation</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Trigeminal Nerve</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Reaction Time</term><term>Trigeminal Nerve</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Dose-Response Relationship, Radiation</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the hypothesis that Parkinsons's disease (PD) is associated with abnormal plasticity of the neuronal circuits mediating blink reflex. We induced long-term potentiation (LTP)-like plasticity in trigeminal wide dynamic range neurons of the blink reflex circuit by pairing an high-frequency train of electrical stimuli over the right supraorbital nerve (SO) coincident with the R2 response elicited by a preceding SO stimulus. The facilitation of the R2 response after the induction protocol was markedly decreased in patients relative to controls. Treatment with dopaminergic drugs normalized the LTP-like plasticity of the R2 response. We conclude that nigrostriatal denervation disrupts LTP-like plasticity in the trigeminal reflex circuit.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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