Tetrabenazine therapy of pediatric hyperkinetic movement disorders.
Identifieur interne : 001822 ( Ncbi/Curation ); précédent : 001821; suivant : 001823Tetrabenazine therapy of pediatric hyperkinetic movement disorders.
Auteurs : Samay Jain [États-Unis] ; Paul E. Greene ; Steven J. FruchtSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-Dyskinesia Agents, Tetrabenazine.
- drug therapy : Hyperkinesis.
- Adolescent, Child, Child, Preschool, Dose-Response Relationship, Drug, Drug Tolerance, Female, Follow-Up Studies, Humans, Infant, Male, Pediatrics, Retrospective Studies.
Abstract
Tetrabenazine (TBZ), a presynaptic dopamine depletor and postsynaptic dopamine receptor blocker, is widely used for the treatment of hyperkinetic movement disorders in adults. However, reports of its use in children are limited. We review the efficacy and tolerability of TBZ therapy in 31 children with hyperkinetic movement disorders refractory to other medications. TBZ was effective in reducing the severity of movement disorders resistant to treatment with other medicines. When compared to adult patients, pediatric patients required higher doses. Side effects were similar to the adult population; however, children had a lower incidence of drug-induced Parkinsonism.
DOI: 10.1002/mds.21063
PubMed: 16958131
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