Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: autonomic symptom and demographic comparison.
Identifieur interne : 001820 ( Ncbi/Curation ); précédent : 001819; suivant : 001821Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: autonomic symptom and demographic comparison.
Auteurs : Liesl M. Allcock [Royaume-Uni] ; Rose Anne Kenny ; David J. BurnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Autonomic Nervous System (physiopathology), Chi-Square Distribution, Demography, Female, Humans, Hypotension, Orthostatic (epidemiology), Hypotension, Orthostatic (etiology), Male, Parkinson Disease (complications), Parkinson Disease (epidemiology), Phenotype, Regression (Psychology), Severity of Illness Index.
- MESH :
- complications : Parkinson Disease.
- epidemiology : Hypotension, Orthostatic, Parkinson Disease.
- etiology : Hypotension, Orthostatic.
- physiopathology : Autonomic Nervous System.
- Aged, Aged, 80 and over, Chi-Square Distribution, Demography, Female, Humans, Male, Phenotype, Regression (Psychology), Severity of Illness Index.
Abstract
The objective of this study was to characterize the phenotypic associations of orthostatic hypotension (OH) in Parkinson's disease (PD). One hundred fifty-nine subjects with PD underwent assessment including autonomic symptom severity scoring, disease-specific rating scales, and measurement of postural blood pressure response. Symptoms of autonomic impairment weakly correlated with disease duration and severity. A posture and gait instability (PIGD) motor phenotype was associated with greater severity of autonomic symptoms. Eighty subjects (50.3%) had OH. These subjects were older, more likely to be male, and taking larger doses of dopaminergic medications than those without OH. There was no difference in disease severity or duration between those with and those without OH. Symptomatic dizziness did not distinguish between groups, although subjects with OH had more symptoms of generalized autonomic impairment than those without. Progressive autonomic involvement may be linked to disease progression in PD, particularly in patients with a PIGD phenotype, but dichotomization into groups with and without OH is a relatively insensitive method for demonstrating this. Longitudinal studies of changes in autonomic reflex abnormalities, autonomic symptom profiles, and motor severity might clarify these associations.
DOI: 10.1002/mds.20996
PubMed: 16958096
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: autonomic symptom and demographic comparison.</title><author><name sortKey="Allcock, Liesl M" sort="Allcock, Liesl M" uniqKey="Allcock L" first="Liesl M" last="Allcock">Liesl M. Allcock</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Ageing and Health, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom. l.m.allcock@ncl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Ageing and Health, University of Newcastle Upon Tyne, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Kenny, Rose Anne" sort="Kenny, Rose Anne" uniqKey="Kenny R" first="Rose Anne" last="Kenny">Rose Anne Kenny</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20996</idno><idno type="RBID">pubmed:16958096</idno><idno type="pmid">16958096</idno><idno type="wicri:Area/PubMed/Corpus">002B19</idno><idno type="wicri:Area/PubMed/Curation">002B19</idno><idno type="wicri:Area/PubMed/Checkpoint">002E17</idno><idno type="wicri:Area/Ncbi/Merge">001820</idno><idno type="wicri:Area/Ncbi/Curation">001820</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: autonomic symptom and demographic comparison.</title><author><name sortKey="Allcock, Liesl M" sort="Allcock, Liesl M" uniqKey="Allcock L" first="Liesl M" last="Allcock">Liesl M. Allcock</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Ageing and Health, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom. l.m.allcock@ncl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Ageing and Health, University of Newcastle Upon Tyne, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Kenny, Rose Anne" sort="Kenny, Rose Anne" uniqKey="Kenny R" first="Rose Anne" last="Kenny">Rose Anne Kenny</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Autonomic Nervous System (physiopathology)</term><term>Chi-Square Distribution</term><term>Demography</term><term>Female</term><term>Humans</term><term>Hypotension, Orthostatic (epidemiology)</term><term>Hypotension, Orthostatic (etiology)</term><term>Male</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Phenotype</term><term>Regression (Psychology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypotension, Orthostatic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypotension, Orthostatic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Chi-Square Distribution</term><term>Demography</term><term>Female</term><term>Humans</term><term>Male</term><term>Phenotype</term><term>Regression (Psychology)</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to characterize the phenotypic associations of orthostatic hypotension (OH) in Parkinson's disease (PD). One hundred fifty-nine subjects with PD underwent assessment including autonomic symptom severity scoring, disease-specific rating scales, and measurement of postural blood pressure response. Symptoms of autonomic impairment weakly correlated with disease duration and severity. A posture and gait instability (PIGD) motor phenotype was associated with greater severity of autonomic symptoms. Eighty subjects (50.3%) had OH. These subjects were older, more likely to be male, and taking larger doses of dopaminergic medications than those without OH. There was no difference in disease severity or duration between those with and those without OH. Symptomatic dizziness did not distinguish between groups, although subjects with OH had more symptoms of generalized autonomic impairment than those without. Progressive autonomic involvement may be linked to disease progression in PD, particularly in patients with a PIGD phenotype, but dichotomization into groups with and without OH is a relatively insensitive method for demonstrating this. Longitudinal studies of changes in autonomic reflex abnormalities, autonomic symptom profiles, and motor severity might clarify these associations.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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