Fulminant Lewy body disease.
Identifieur interne : 001771 ( Ncbi/Curation ); précédent : 001770; suivant : 001772Fulminant Lewy body disease.
Auteurs : Isabelle Momjian-Mayor [Suisse] ; Gian Paolo Pizzolato ; Karim Burkhardt ; Theodor Landis ; Alessandra Coeytaux ; Pierre R. BurkhardSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- 14-3-3 Proteins (analysis), Aged, Brain (pathology), Creutzfeldt-Jakob Syndrome (diagnosis), Creutzfeldt-Jakob Syndrome (pathology), Diagnosis, Differential, Disease Progression, Fatal Outcome, Humans, Lewy Bodies (pathology), Lewy Body Disease (diagnosis), Lewy Body Disease (pathology), Male, Neurologic Examination, Neuropsychological Tests, Parkinson Disease (diagnosis), Parkinson Disease (pathology).
- MESH :
- chemical , analysis : 14-3-3 Proteins.
- diagnosis : Creutzfeldt-Jakob Syndrome, Lewy Body Disease, Parkinson Disease.
- pathology : Brain, Creutzfeldt-Jakob Syndrome, Lewy Bodies, Lewy Body Disease, Parkinson Disease.
- Aged, Diagnosis, Differential, Disease Progression, Fatal Outcome, Humans, Male, Neurologic Examination, Neuropsychological Tests.
Abstract
The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity.
DOI: 10.1002/mds.21034
PubMed: 16830307
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Burkhard</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>14-3-3 Proteins (analysis)</term><term>Aged</term><term>Brain (pathology)</term><term>Creutzfeldt-Jakob Syndrome (diagnosis)</term><term>Creutzfeldt-Jakob Syndrome (pathology)</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Fatal Outcome</term><term>Humans</term><term>Lewy Bodies (pathology)</term><term>Lewy Body Disease (diagnosis)</term><term>Lewy Body Disease (pathology)</term><term>Male</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>14-3-3 Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Creutzfeldt-Jakob Syndrome</term><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Creutzfeldt-Jakob Syndrome</term><term>Lewy Bodies</term><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Fatal Outcome</term><term>Humans</term><term>Male</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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