Validity of the 30-item geriatric depression scale in patients with Parkinson's disease.
Identifieur interne : 001768 ( Ncbi/Curation ); précédent : 001767; suivant : 001769Validity of the 30-item geriatric depression scale in patients with Parkinson's disease.
Auteurs : William M. Mcdonald [États-Unis] ; Paul E. Holtzheimer ; Michael Haber ; Jerrold L. Vitek ; Kimberly Mcwhorter ; Mahlon DelongSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Depressive Disorder, Major (diagnosis), Depressive Disorder, Major (psychology), Female, Geriatric Assessment (statistics & numerical data), Humans, Male, Middle Aged, Pallidotomy, Parkinson Disease (psychology), Parkinson Disease (surgery), Personality Inventory (statistics & numerical data), Postoperative Complications (diagnosis), Postoperative Complications (psychology), Psychometrics (statistics & numerical data), ROC Curve, Reproducibility of Results.
- MESH :
- diagnosis : Depressive Disorder, Major, Postoperative Complications.
- psychology : Depressive Disorder, Major, Parkinson Disease, Postoperative Complications.
- statistics & numerical data : Geriatric Assessment, Personality Inventory, Psychometrics.
- surgery : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Pallidotomy, ROC Curve, Reproducibility of Results.
Abstract
Depression in Parkinson's disease (dPD) is difficult to diagnose because depressive symptoms can overlap with symptoms of Parkinson's disease (PD). Subject-rated scales such as the 30-item Geriatric Depression Scale (GDS) may be useful in screening for dPD. There were 57 patients (33 men, 24 women; mean age, 58.6 years [SD +/- 8.4]) enrolled in a study of pallidotomy for intractable PD who were evaluated for depression before and after surgery. Subjects were evaluated using the 17-item Hamilton Depression Rating Scale (HDRS), Structured Clinical Interview for Diagnostic and Statistical Manual-III (SCID), and the GDS. SCID was used to diagnose major depression with confirmation by an expert geropsychiatrist. Receiver-operating curves (ROC) were used to identify cutoff points with maximal discriminant validity for diagnosing dPD. A total of 213 evaluation time points were included for the 52 patients with time points that included a valid SCID diagnosis, GDS, and HDRS. A ROC established points of maximum specificity/sensitivity for the GDS at a cutoff of 9/10 (sensitivity = 0.809, specificity = 0.837, positive predictive value [PPV] = 0.584, negative predictive value [NPV] = 0.939) and for the HDRS at a cutoff of 12/13 (sensitivity = 0.810, specificity = 0.821, PPV = 0.580, NPV = 0.934). The GDS was moderately correlated with the HDRS (Pearson's r = 0.54; P < 0.001). The GDS is useful in screening for dPD. A cutoff score of 9/10 has acceptable discriminant validity for dPD, and the GDS has a moderate correlation with the HDRS in PD patients.
DOI: 10.1002/mds.21023
PubMed: 16817205
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Validity of the 30-item geriatric depression scale in patients with Parkinson's disease.</title><author><name sortKey="Mcdonald, William M" sort="Mcdonald, William M" uniqKey="Mcdonald W" first="William M" last="Mcdonald">William M. Mcdonald</name><affiliation wicri:level="1"><nlm:affiliation>Fuqua Center for Late-Life Depression, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329-5102, USA. wmcdona@emory.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fuqua Center for Late-Life Depression, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329-5102</wicri:regionArea><wicri:noRegion>Georgia 30329-5102</wicri:noRegion></affiliation></author><author><name sortKey="Holtzheimer, Paul E" sort="Holtzheimer, Paul E" uniqKey="Holtzheimer P" first="Paul E" last="Holtzheimer">Paul E. Holtzheimer</name></author><author><name sortKey="Haber, Michael" sort="Haber, Michael" uniqKey="Haber M" first="Michael" last="Haber">Michael Haber</name></author><author><name sortKey="Vitek, Jerrold L" sort="Vitek, Jerrold L" uniqKey="Vitek J" first="Jerrold L" last="Vitek">Jerrold L. Vitek</name></author><author><name sortKey="Mcwhorter, Kimberly" sort="Mcwhorter, Kimberly" uniqKey="Mcwhorter K" first="Kimberly" last="Mcwhorter">Kimberly Mcwhorter</name></author><author><name sortKey="Delong, Mahlon" sort="Delong, Mahlon" uniqKey="Delong M" first="Mahlon" last="Delong">Mahlon Delong</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.21023</idno><idno type="RBID">pubmed:16817205</idno><idno type="pmid">16817205</idno><idno type="wicri:Area/PubMed/Corpus">002B69</idno><idno type="wicri:Area/PubMed/Curation">002B69</idno><idno type="wicri:Area/PubMed/Checkpoint">002A34</idno><idno type="wicri:Area/Ncbi/Merge">001768</idno><idno type="wicri:Area/Ncbi/Curation">001768</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Validity of the 30-item geriatric depression scale in patients with Parkinson's disease.</title><author><name sortKey="Mcdonald, William M" sort="Mcdonald, William M" uniqKey="Mcdonald W" first="William M" last="Mcdonald">William M. Mcdonald</name><affiliation wicri:level="1"><nlm:affiliation>Fuqua Center for Late-Life Depression, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329-5102, USA. wmcdona@emory.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fuqua Center for Late-Life Depression, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329-5102</wicri:regionArea><wicri:noRegion>Georgia 30329-5102</wicri:noRegion></affiliation></author><author><name sortKey="Holtzheimer, Paul E" sort="Holtzheimer, Paul E" uniqKey="Holtzheimer P" first="Paul E" last="Holtzheimer">Paul E. Holtzheimer</name></author><author><name sortKey="Haber, Michael" sort="Haber, Michael" uniqKey="Haber M" first="Michael" last="Haber">Michael Haber</name></author><author><name sortKey="Vitek, Jerrold L" sort="Vitek, Jerrold L" uniqKey="Vitek J" first="Jerrold L" last="Vitek">Jerrold L. Vitek</name></author><author><name sortKey="Mcwhorter, Kimberly" sort="Mcwhorter, Kimberly" uniqKey="Mcwhorter K" first="Kimberly" last="Mcwhorter">Kimberly Mcwhorter</name></author><author><name sortKey="Delong, Mahlon" sort="Delong, Mahlon" uniqKey="Delong M" first="Mahlon" last="Delong">Mahlon Delong</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Depressive Disorder, Major (diagnosis)</term><term>Depressive Disorder, Major (psychology)</term><term>Female</term><term>Geriatric Assessment (statistics & numerical data)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pallidotomy</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (surgery)</term><term>Personality Inventory (statistics & numerical data)</term><term>Postoperative Complications (diagnosis)</term><term>Postoperative Complications (psychology)</term><term>Psychometrics (statistics & numerical data)</term><term>ROC Curve</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Depressive Disorder, Major</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depressive Disorder, Major</term><term>Parkinson Disease</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Geriatric Assessment</term><term>Personality Inventory</term><term>Psychometrics</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pallidotomy</term><term>ROC Curve</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depression in Parkinson's disease (dPD) is difficult to diagnose because depressive symptoms can overlap with symptoms of Parkinson's disease (PD). Subject-rated scales such as the 30-item Geriatric Depression Scale (GDS) may be useful in screening for dPD. There were 57 patients (33 men, 24 women; mean age, 58.6 years [SD +/- 8.4]) enrolled in a study of pallidotomy for intractable PD who were evaluated for depression before and after surgery. Subjects were evaluated using the 17-item Hamilton Depression Rating Scale (HDRS), Structured Clinical Interview for Diagnostic and Statistical Manual-III (SCID), and the GDS. SCID was used to diagnose major depression with confirmation by an expert geropsychiatrist. Receiver-operating curves (ROC) were used to identify cutoff points with maximal discriminant validity for diagnosing dPD. A total of 213 evaluation time points were included for the 52 patients with time points that included a valid SCID diagnosis, GDS, and HDRS. A ROC established points of maximum specificity/sensitivity for the GDS at a cutoff of 9/10 (sensitivity = 0.809, specificity = 0.837, positive predictive value [PPV] = 0.584, negative predictive value [NPV] = 0.939) and for the HDRS at a cutoff of 12/13 (sensitivity = 0.810, specificity = 0.821, PPV = 0.580, NPV = 0.934). The GDS was moderately correlated with the HDRS (Pearson's r = 0.54; P < 0.001). The GDS is useful in screening for dPD. A cutoff score of 9/10 has acceptable discriminant validity for dPD, and the GDS has a moderate correlation with the HDRS in PD patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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