Expectation and the placebo effect in Parkinson's disease patients with subthalamic nucleus deep brain stimulation.
Identifieur interne : 001711 ( Ncbi/Curation ); précédent : 001710; suivant : 001712Expectation and the placebo effect in Parkinson's disease patients with subthalamic nucleus deep brain stimulation.
Auteurs : Rodrigo Mercado [Canada] ; Constantine Constantoyannis ; Tomasz Mandat ; Ajit Kumar ; Michael Schulzer ; A Jon Stoessl ; Christopher R. HoneySource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (administration & dosage), Awareness, Combined Modality Therapy, Deep Brain Stimulation (psychology), Dominance, Cerebral (physiology), Dopamine Agonists (administration & dosage), Double-Blind Method, Female, Humans, Hypokinesia (physiopathology), Hypokinesia (psychology), Hypokinesia (rehabilitation), Levodopa (administration & dosage), Male, Middle Aged, Neurologic Examination, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson Disease (rehabilitation), Placebo Effect, Set (Psychology), Subthalamic Nucleus (physiopathology).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Dopamine Agonists, Levodopa.
- physiology : Dominance, Cerebral.
- physiopathology : Hypokinesia, Parkinson Disease, Subthalamic Nucleus.
- psychology : Deep Brain Stimulation, Hypokinesia, Parkinson Disease.
- rehabilitation : Hypokinesia, Parkinson Disease.
- Adult, Aged, Awareness, Combined Modality Therapy, Double-Blind Method, Female, Humans, Male, Middle Aged, Neurologic Examination, Placebo Effect, Set (Psychology).
Abstract
To determine whether the degree to which a patient with Parkinson's disease expects therapeutic benefit from subthalamic nucleus-deep brain stimulation (STN-DBS) influences the magnitude of his or her improved motor response, 10 patients with idiopathic Parkinson's and bilateral STN-DBS were tested after a 12-hour period off medication and stimulation. Four consecutive UPDRS III scores were performed in the following conditions: (a) stimulation OFF, patient aware; (b) stimulation OFF, patient blind; (c) stimulation ON, patient aware; and (d) stimulation ON, patient blind. Statistical significance (P = 0.0001) was observed when comparing main effect ON versus OFF (mean ON: 32.55; mean OFF: 49.15). When the stimulation was OFF, patients aware of this condition had higher UPDRS motor scores than when they were blinded (mean: 50.7 vs. 47.6). With the stimulation ON, UPDRS motor scores were lower when the patients were aware of the stimulation compared with when they were blinded (mean: 30.6 vs. 34.5). The interaction between these levels was significant (P = 0.049). This variation was important for bradykinesia and was not significant for tremor and rigidity. The authors conclude that the information about the condition of the stimulation enhanced the final clinical effect in opposite directions. The results presented support the role of expectation and placebo effects in STN-DBS in Parkinson's disease patients.
DOI: 10.1002/mds.20935
PubMed: 16721750
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Honey</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20935</idno><idno type="RBID">pubmed:16721750</idno><idno type="pmid">16721750</idno><idno type="wicri:Area/PubMed/Corpus">002C23</idno><idno type="wicri:Area/PubMed/Curation">002C23</idno><idno type="wicri:Area/PubMed/Checkpoint">002D29</idno><idno type="wicri:Area/Ncbi/Merge">001711</idno><idno type="wicri:Area/Ncbi/Curation">001711</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Expectation and the placebo effect in Parkinson's disease patients with subthalamic nucleus deep brain stimulation.</title><author><name sortKey="Mercado, Rodrigo" sort="Mercado, Rodrigo" uniqKey="Mercado R" first="Rodrigo" last="Mercado">Rodrigo Mercado</name><affiliation wicri:level="1"><nlm:affiliation>Surgical Centre for Movement Disorders, University of British Columbia, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Surgical Centre for Movement Disorders, University of British Columbia, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Constantoyannis, Constantine" sort="Constantoyannis, Constantine" uniqKey="Constantoyannis C" first="Constantine" last="Constantoyannis">Constantine Constantoyannis</name></author><author><name sortKey="Mandat, Tomasz" sort="Mandat, Tomasz" uniqKey="Mandat T" first="Tomasz" last="Mandat">Tomasz Mandat</name></author><author><name sortKey="Kumar, Ajit" sort="Kumar, Ajit" uniqKey="Kumar A" first="Ajit" last="Kumar">Ajit Kumar</name></author><author><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name></author><author><name sortKey="Honey, Christopher R" sort="Honey, Christopher R" uniqKey="Honey C" first="Christopher R" last="Honey">Christopher R. Honey</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Awareness</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation (psychology)</term><term>Dominance, Cerebral (physiology)</term><term>Dopamine Agonists (administration & dosage)</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Hypokinesia (physiopathology)</term><term>Hypokinesia (psychology)</term><term>Hypokinesia (rehabilitation)</term><term>Levodopa (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (rehabilitation)</term><term>Placebo Effect</term><term>Set (Psychology)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Deep Brain Stimulation</term><term>Hypokinesia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Awareness</term><term>Combined Modality Therapy</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Placebo Effect</term><term>Set (Psychology)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether the degree to which a patient with Parkinson's disease expects therapeutic benefit from subthalamic nucleus-deep brain stimulation (STN-DBS) influences the magnitude of his or her improved motor response, 10 patients with idiopathic Parkinson's and bilateral STN-DBS were tested after a 12-hour period off medication and stimulation. Four consecutive UPDRS III scores were performed in the following conditions: (a) stimulation OFF, patient aware; (b) stimulation OFF, patient blind; (c) stimulation ON, patient aware; and (d) stimulation ON, patient blind. Statistical significance (P = 0.0001) was observed when comparing main effect ON versus OFF (mean ON: 32.55; mean OFF: 49.15). When the stimulation was OFF, patients aware of this condition had higher UPDRS motor scores than when they were blinded (mean: 50.7 vs. 47.6). With the stimulation ON, UPDRS motor scores were lower when the patients were aware of the stimulation compared with when they were blinded (mean: 30.6 vs. 34.5). The interaction between these levels was significant (P = 0.049). This variation was important for bradykinesia and was not significant for tremor and rigidity. The authors conclude that the information about the condition of the stimulation enhanced the final clinical effect in opposite directions. The results presented support the role of expectation and placebo effects in STN-DBS in Parkinson's disease patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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