Levodopa-induced sleepiness in the Parkinson variant of multiple system atrophy.
Identifieur interne : 001657 ( Ncbi/Curation ); précédent : 001656; suivant : 001658Levodopa-induced sleepiness in the Parkinson variant of multiple system atrophy.
Auteurs : Klaus Seppi [Autriche] ; Birgit Högl ; Anja Diem ; Cecilia Peralta ; Gregor K. Wenning ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Disorders of Excessive Somnolence (chemically induced), Dopamine Agents (adverse effects), Humans, Levodopa (adverse effects), Middle Aged, Multiple System Atrophy (chemically induced), Multiple System Atrophy (physiopathology), Parkinson Disease (complications), Parkinson Disease (drug therapy).
- MESH :
- chemical , adverse effects : Dopamine Agents, Levodopa.
- chemically induced : Disorders of Excessive Somnolence, Multiple System Atrophy.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- physiopathology : Multiple System Atrophy.
- Aged, Humans, Middle Aged.
Abstract
Recent observations suggest that levodopa can induce irresistible sleep onset in multiple system atrophy (MSA). Therefore, we assessed sleepiness during a levodopa challenge in 17 MSA compared with 23 Parkinson's disease (PD) patients using the Stanford Sleepiness Scale (SSS). SSS scores during the levodopa challenge compared with baseline were significantly increased in the MSA compared with the PD group. These findings suggest greater potential of levodopa to induce sleepiness in MSA compared with PD, which may be related to differences in basal ganglia and brainstem pathology between the two disorders.
DOI: 10.1002/mds.20898
PubMed: 16639726
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pubmed:16639726Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
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<author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name>
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<author><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name>
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<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name>
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<author><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name>
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<author><name sortKey="Peralta, Cecilia" sort="Peralta, Cecilia" uniqKey="Peralta C" first="Cecilia" last="Peralta">Cecilia Peralta</name>
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<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (chemically induced)</term>
<term>Multiple System Atrophy (physiopathology)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
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<front><div type="abstract" xml:lang="en">Recent observations suggest that levodopa can induce irresistible sleep onset in multiple system atrophy (MSA). Therefore, we assessed sleepiness during a levodopa challenge in 17 MSA compared with 23 Parkinson's disease (PD) patients using the Stanford Sleepiness Scale (SSS). SSS scores during the levodopa challenge compared with baseline were significantly increased in the MSA compared with the PD group. These findings suggest greater potential of levodopa to induce sleepiness in MSA compared with PD, which may be related to differences in basal ganglia and brainstem pathology between the two disorders.</div>
</front>
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