Predictors of weight loss in Parkinson's disease.
Identifieur interne : 001594 ( Ncbi/Curation ); précédent : 001593; suivant : 001595Predictors of weight loss in Parkinson's disease.
Auteurs : Ergun Y. Uc [États-Unis] ; Lynn K. Struck ; Robert L. Rodnitzky ; Bridget Zimmerman ; Judith Dobson ; William J. EvansSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
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Abstract
The objective of this study was to examine the change of body weight (BW) among Parkinson's disease (PD) patients and controls over years and determine the predictors of weight loss among PD patients. Studies on weight loss in PD studies are cross-sectional, have a short follow-up, or lack in clinical detail. We examined the percentage of BW change over years among 49 PD patients and 78 controls. The controls were from another study on longitudinal evolution of BW and body composition in the elderly. We determined the BW, Hoehn and Yahr (HY) stage, and dyskinesia status of 49 consecutive nondemented PD patients with symptom duration of 6.1 +/- 0.7 years (mean +/- SEM) and ascertained their BW at the time of diagnosis and 2.4 +/- 0.2 years before the diagnosis from medical records. We collected data again 7.2 +/- 0.5 years after the first visit. The PD group lost 7.7% +/- 1.5% of BW over the entire symptomatic period (13.1 +/- 0.8 years), while the control group lost only 0.2% +/- 0.7% of BW over 9.9 +/- 0.1 years; weight loss was clinically significant (>5%) in 55.6% of PD patients vs. 20.5% of the controls (both P values < 0.001, adjusted for sex, baseline age, and observation period duration). PD patients lost weight in both the early and advanced phases. While worsening of parkinsonism was the most important factor, age at diagnosis, emergence of visual hallucinations, and possibly dementia were also associated with weight loss. We demonstrated significant weight loss in PD patients compared to controls over approximately 1 decade. Neurodegeneration involving both motor and nonmotor systems may be associated with weight loss in PD.
DOI: 10.1002/mds.20837
PubMed: 16534756
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Predictors of weight loss in Parkinson's disease.</title><author><name sortKey="Uc, Ergun Y" sort="Uc, Ergun Y" uniqKey="Uc E" first="Ergun Y" last="Uc">Ergun Y. Uc</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. ergun-uc@uiowa.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242</wicri:regionArea><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Struck, Lynn K" sort="Struck, Lynn K" uniqKey="Struck L" first="Lynn K" last="Struck">Lynn K. Struck</name></author><author><name sortKey="Rodnitzky, Robert L" sort="Rodnitzky, Robert L" uniqKey="Rodnitzky R" first="Robert L" last="Rodnitzky">Robert L. Rodnitzky</name></author><author><name sortKey="Zimmerman, Bridget" sort="Zimmerman, Bridget" uniqKey="Zimmerman B" first="Bridget" last="Zimmerman">Bridget Zimmerman</name></author><author><name sortKey="Dobson, Judith" sort="Dobson, Judith" uniqKey="Dobson J" first="Judith" last="Dobson">Judith Dobson</name></author><author><name sortKey="Evans, William J" sort="Evans, William J" uniqKey="Evans W" first="William J" last="Evans">William J. 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Uc</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. ergun-uc@uiowa.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242</wicri:regionArea><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Struck, Lynn K" sort="Struck, Lynn K" uniqKey="Struck L" first="Lynn K" last="Struck">Lynn K. Struck</name></author><author><name sortKey="Rodnitzky, Robert L" sort="Rodnitzky, Robert L" uniqKey="Rodnitzky R" first="Robert L" last="Rodnitzky">Robert L. Rodnitzky</name></author><author><name sortKey="Zimmerman, Bridget" sort="Zimmerman, Bridget" uniqKey="Zimmerman B" first="Bridget" last="Zimmerman">Bridget Zimmerman</name></author><author><name sortKey="Dobson, Judith" sort="Dobson, Judith" uniqKey="Dobson J" first="Judith" last="Dobson">Judith Dobson</name></author><author><name sortKey="Evans, William J" sort="Evans, William J" uniqKey="Evans W" first="William J" last="Evans">William J. Evans</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Disability Evaluation</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Hallucinations (diagnosis)</term><term>Humans</term><term>Lewy Body Disease (diagnosis)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Reference Values</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Weight Loss</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hallucinations</term><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disability Evaluation</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Weight Loss</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to examine the change of body weight (BW) among Parkinson's disease (PD) patients and controls over years and determine the predictors of weight loss among PD patients. Studies on weight loss in PD studies are cross-sectional, have a short follow-up, or lack in clinical detail. We examined the percentage of BW change over years among 49 PD patients and 78 controls. The controls were from another study on longitudinal evolution of BW and body composition in the elderly. We determined the BW, Hoehn and Yahr (HY) stage, and dyskinesia status of 49 consecutive nondemented PD patients with symptom duration of 6.1 +/- 0.7 years (mean +/- SEM) and ascertained their BW at the time of diagnosis and 2.4 +/- 0.2 years before the diagnosis from medical records. We collected data again 7.2 +/- 0.5 years after the first visit. The PD group lost 7.7% +/- 1.5% of BW over the entire symptomatic period (13.1 +/- 0.8 years), while the control group lost only 0.2% +/- 0.7% of BW over 9.9 +/- 0.1 years; weight loss was clinically significant (>5%) in 55.6% of PD patients vs. 20.5% of the controls (both P values < 0.001, adjusted for sex, baseline age, and observation period duration). PD patients lost weight in both the early and advanced phases. While worsening of parkinsonism was the most important factor, age at diagnosis, emergence of visual hallucinations, and possibly dementia were also associated with weight loss. We demonstrated significant weight loss in PD patients compared to controls over approximately 1 decade. Neurodegeneration involving both motor and nonmotor systems may be associated with weight loss in PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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