Changes in cortical inhibition during task-specific contractions in primary writing tremor patients.
Identifieur interne : 001574 ( Ncbi/Curation ); précédent : 001573; suivant : 001575Changes in cortical inhibition during task-specific contractions in primary writing tremor patients.
Auteurs : Milos Ljubisavljevic [Serbie] ; Aleksandra Kacar ; Sladjan Milanovic ; Marina Svetel ; Vladimir S. KosticSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Dystonic Disorders (physiopathology), Dystonic Disorders (therapy), Electromyography, Functional Laterality, Humans, Middle Aged, Motor Activity (physiology), Motor Cortex (physiopathology), Muscle Contraction (physiology), Reference Values, Transcranial Magnetic Stimulation, Treatment Outcome, Tremor (etiology), Tremor (physiopathology).
- MESH :
- etiology : Tremor.
- physiology : Motor Activity, Muscle Contraction.
- physiopathology : Dystonic Disorders, Motor Cortex, Tremor.
- therapy : Dystonic Disorders.
- Adult, Age of Onset, Aged, Electromyography, Functional Laterality, Humans, Middle Aged, Reference Values, Transcranial Magnetic Stimulation, Treatment Outcome.
Abstract
Primary writing tremor (PWT) is a rare disease of unknown pathophysiology. We studied changes in silent period (SP) duration, after transcranial magnetic stimulation (TMS), set at 20% above the motor threshold in 6 PWT patients and 7 healthy control subjects. SP duration was tested during a task-specific act, i.e., writing that induced tremor in all patients in the affected hand (Wr); nonspecific voluntary contraction of intensity, matching that developed during writing (VCWr); and during near maximal voluntary contraction (VCNmax). There were no differences in SP duration during Wr and VCWr contraction on the right affected side or between sides in both PWT patients and control subjects, nor between the groups. However, during VCNmax, SP significantly shortened on both sides in PWT patients, whereas there were no changes in control subjects. Although it appears that inhibitory mechanism are not directly involved in the generation of the tremulous activity, the shortening of SP indicates that central inhibitory mechanisms are affected in PWT patients. Therefore, whereas the underlying pathophysiological mechanisms in PWT and writer's cramp may share common features, the results indicate that PWT is not a variant of focal task-specific dystonia but rather a separate nosological entity.
DOI: 10.1002/mds.20807
PubMed: 16482535
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002D57
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002D57
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002E26
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001574
Links to Exploration step
pubmed:16482535Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changes in cortical inhibition during task-specific contractions in primary writing tremor patients.</title><author><name sortKey="Ljubisavljevic, Milos" sort="Ljubisavljevic, Milos" uniqKey="Ljubisavljevic M" first="Milos" last="Ljubisavljevic">Milos Ljubisavljevic</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Neurophysiology, Institute for Medical Research, Belgrade, Serbia. milos@imi.bg.ac.yu</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Laboratory for Neurophysiology, Institute for Medical Research, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Kacar, Aleksandra" sort="Kacar, Aleksandra" uniqKey="Kacar A" first="Aleksandra" last="Kacar">Aleksandra Kacar</name></author><author><name sortKey="Milanovic, Sladjan" sort="Milanovic, Sladjan" uniqKey="Milanovic S" first="Sladjan" last="Milanovic">Sladjan Milanovic</name></author><author><name sortKey="Svetel, Marina" sort="Svetel, Marina" uniqKey="Svetel M" first="Marina" last="Svetel">Marina Svetel</name></author><author><name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S" last="Kostic">Vladimir S. Kostic</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20807</idno><idno type="RBID">pubmed:16482535</idno><idno type="pmid">16482535</idno><idno type="wicri:Area/PubMed/Corpus">002D57</idno><idno type="wicri:Area/PubMed/Curation">002D57</idno><idno type="wicri:Area/PubMed/Checkpoint">002E26</idno><idno type="wicri:Area/Ncbi/Merge">001574</idno><idno type="wicri:Area/Ncbi/Curation">001574</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changes in cortical inhibition during task-specific contractions in primary writing tremor patients.</title><author><name sortKey="Ljubisavljevic, Milos" sort="Ljubisavljevic, Milos" uniqKey="Ljubisavljevic M" first="Milos" last="Ljubisavljevic">Milos Ljubisavljevic</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Neurophysiology, Institute for Medical Research, Belgrade, Serbia. milos@imi.bg.ac.yu</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Laboratory for Neurophysiology, Institute for Medical Research, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Kacar, Aleksandra" sort="Kacar, Aleksandra" uniqKey="Kacar A" first="Aleksandra" last="Kacar">Aleksandra Kacar</name></author><author><name sortKey="Milanovic, Sladjan" sort="Milanovic, Sladjan" uniqKey="Milanovic S" first="Sladjan" last="Milanovic">Sladjan Milanovic</name></author><author><name sortKey="Svetel, Marina" sort="Svetel, Marina" uniqKey="Svetel M" first="Marina" last="Svetel">Marina Svetel</name></author><author><name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S" last="Kostic">Vladimir S. Kostic</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Dystonic Disorders (physiopathology)</term><term>Dystonic Disorders (therapy)</term><term>Electromyography</term><term>Functional Laterality</term><term>Humans</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Motor Cortex (physiopathology)</term><term>Muscle Contraction (physiology)</term><term>Reference Values</term><term>Transcranial Magnetic Stimulation</term><term>Treatment Outcome</term><term>Tremor (etiology)</term><term>Tremor (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term><term>Muscle Contraction</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonic Disorders</term><term>Motor Cortex</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Electromyography</term><term>Functional Laterality</term><term>Humans</term><term>Middle Aged</term><term>Reference Values</term><term>Transcranial Magnetic Stimulation</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary writing tremor (PWT) is a rare disease of unknown pathophysiology. We studied changes in silent period (SP) duration, after transcranial magnetic stimulation (TMS), set at 20% above the motor threshold in 6 PWT patients and 7 healthy control subjects. SP duration was tested during a task-specific act, i.e., writing that induced tremor in all patients in the affected hand (Wr); nonspecific voluntary contraction of intensity, matching that developed during writing (VCWr); and during near maximal voluntary contraction (VCNmax). There were no differences in SP duration during Wr and VCWr contraction on the right affected side or between sides in both PWT patients and control subjects, nor between the groups. However, during VCNmax, SP significantly shortened on both sides in PWT patients, whereas there were no changes in control subjects. Although it appears that inhibitory mechanism are not directly involved in the generation of the tremulous activity, the shortening of SP indicates that central inhibitory mechanisms are affected in PWT patients. Therefore, whereas the underlying pathophysiological mechanisms in PWT and writer's cramp may share common features, the results indicate that PWT is not a variant of focal task-specific dystonia but rather a separate nosological entity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001574 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001574 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:16482535
|texte= Changes in cortical inhibition during task-specific contractions in primary writing tremor patients.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:16482535" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |