Botulinum toxin type A for drooling in Parkinson's disease: a double-blind, randomized, placebo-controlled study.
Identifieur interne : 001554 ( Ncbi/Curation ); précédent : 001553; suivant : 001555Botulinum toxin type A for drooling in Parkinson's disease: a double-blind, randomized, placebo-controlled study.
Auteurs : Giovanni Lagalla [Italie] ; Marzia Millevolte ; Marianna Capecci ; Leandro Provinciali ; Maria Gabriella CeravoloSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Botulinum Toxins, Type A (therapeutic use), Double-Blind Method, Female, Humans, Male, Middle Aged, Neuromuscular Agents (therapeutic use), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Sialorrhea (drug therapy), Sialorrhea (etiology).
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease, Sialorrhea.
- etiology : Sialorrhea.
- physiopathology : Parkinson Disease.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged.
Abstract
To investigate the safety and efficacy of botulinum toxin type A (BoNTX) treatment to reduce sialorrhea in Parkinson's disease (PD), a double-blind, randomized, placebo-controlled study enrolled 32 PD patients complaining of excessive drooling. Patients received either 50 U Botox in each parotid gland or placebo without using ultrasound guidance. Subjects treated with BoNTX experienced a reduction in both drooling frequency and familial and social disability (TimexGroup effect: P<0.01), as well as in saliva production (Time x Group effect: P<0.0001). No adverse events were recorded. BoNTX injections are safe and effective treatment for the management of PD-related drooling.
DOI: 10.1002/mds.20793
PubMed: 16440332
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Ospedaliero Universitaria Ospedali Riuniti, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Millevolte, Marzia" sort="Millevolte, Marzia" uniqKey="Millevolte M" first="Marzia" last="Millevolte">Marzia Millevolte</name></author><author><name sortKey="Capecci, Marianna" sort="Capecci, Marianna" uniqKey="Capecci M" first="Marianna" last="Capecci">Marianna Capecci</name></author><author><name sortKey="Provinciali, Leandro" sort="Provinciali, Leandro" uniqKey="Provinciali L" first="Leandro" last="Provinciali">Leandro Provinciali</name></author><author><name sortKey="Ceravolo, Maria Gabriella" sort="Ceravolo, Maria Gabriella" uniqKey="Ceravolo M" first="Maria Gabriella" last="Ceravolo">Maria Gabriella Ceravolo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20793</idno><idno type="RBID">pubmed:16440332</idno><idno type="pmid">16440332</idno><idno type="wicri:Area/PubMed/Corpus">002D75</idno><idno type="wicri:Area/PubMed/Curation">002D75</idno><idno type="wicri:Area/PubMed/Checkpoint">002E44</idno><idno type="wicri:Area/Ncbi/Merge">001554</idno><idno type="wicri:Area/Ncbi/Curation">001554</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Botulinum toxin type A for drooling in Parkinson's disease: a double-blind, randomized, placebo-controlled study.</title><author><name sortKey="Lagalla, Giovanni" sort="Lagalla, Giovanni" uniqKey="Lagalla G" first="Giovanni" last="Lagalla">Giovanni Lagalla</name><affiliation wicri:level="1"><nlm:affiliation>Clinica di Neuroriabilitazione, Dipartimento di Neuroscienze, Università Politecnica delle Marche, Az. Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica di Neuroriabilitazione, Dipartimento di Neuroscienze, Università Politecnica delle Marche, Az. 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Patients received either 50 U Botox in each parotid gland or placebo without using ultrasound guidance. Subjects treated with BoNTX experienced a reduction in both drooling frequency and familial and social disability (TimexGroup effect: P<0.01), as well as in saliva production (Time x Group effect: P<0.0001). No adverse events were recorded. BoNTX injections are safe and effective treatment for the management of PD-related drooling.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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