In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.
Identifieur interne : 001398 ( Ncbi/Curation ); précédent : 001397; suivant : 001399In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.
Auteurs : Alexander Gerhard [Royaume-Uni] ; Iris Trender-Gerhard ; Federico Turkheimer ; Niall P. Quinn ; Kailash P. Bhatia ; David J. BrooksSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Basal Ganglia (physiopathology), Basal Ganglia (radionuclide imaging), Brain Stem (physiopathology), Brain Stem (radionuclide imaging), Carbon Radioisotopes (diagnostic use), Cell Death (physiology), Female, Frontal Lobe (physiopathology), Frontal Lobe (radionuclide imaging), Humans, Image Processing, Computer-Assisted, Isoquinolines (diagnostic use), Magnetic Resonance Imaging, Male, Microglia (physiology), Microglia (radionuclide imaging), Middle Aged, Neurodegenerative Diseases (physiopathology), Neurodegenerative Diseases (radionuclide imaging), Neurons (physiology), Receptors, GABA-A (physiology), Reference Values, Stereoisomerism, Supranuclear Palsy, Progressive (physiopathology), Supranuclear Palsy, Progressive (radionuclide imaging).
- MESH :
- chemical , diagnostic use : Carbon Radioisotopes, Isoquinolines.
- physiology : Cell Death, Microglia, Neurons, Receptors, GABA-A.
- physiopathology : Basal Ganglia, Brain Stem, Frontal Lobe, Neurodegenerative Diseases, Supranuclear Palsy, Progressive.
- radionuclide imaging : Basal Ganglia, Brain Stem, Frontal Lobe, Microglia, Neurodegenerative Diseases, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Stereoisomerism.
Abstract
Progressive supranuclear palsy (PSP) is a neurodegenerative disease presenting with voluntary gaze difficulties, early falls, and Parkinsonism. Neuronal loss, associated with intracellular neurofibrillary tangles and activated microglia, is found targeting the basal ganglia, brainstem nuclei, and frontal cortex. [11C](R)-PK11195 PET is a marker of peripheral benzodiazepine binding sites (PBBS) expressed by activated microglia. We have used [11C](R)-PK11195 PET to demonstrate in vivo the degree and distribution of the glial response to the degenerative process in four patients with PSP. Compared to normal age-matched controls, the PSP patient group showed significantly increased mean [11C](R)-PK11195 binding in the basal ganglia, midbrain, the frontal lobe, and the cerebellum. Two of the patients were rescanned after 6 to 10 months and during that time the level of microglial activation remained stable. [11C](R)-PK11195 PET reveals a pattern of increased microglial activation in PSP patients involving cortical and subcortical regions that corresponds well with the known distribution of neuropathological changes. [11C](R)-PK11195 PET, therefore, may help in characterizing in vivo the underlying disease activity in PSP.
DOI: 10.1002/mds.20668
PubMed: 16108021
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Quinn</name></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P" last="Bhatia">Kailash P. Bhatia</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20668</idno><idno type="RBID">pubmed:16108021</idno><idno type="pmid">16108021</idno><idno type="wicri:Area/PubMed/Corpus">002F14</idno><idno type="wicri:Area/PubMed/Curation">002F14</idno><idno type="wicri:Area/PubMed/Checkpoint">002C74</idno><idno type="wicri:Area/Ncbi/Merge">001398</idno><idno type="wicri:Area/Ncbi/Curation">001398</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.</title><author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name><affiliation wicri:level="3"><nlm:affiliation>MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, and National Hospital for Neurology and Neurosurgery, London, United Kingdom. alexander.gerhard@csc.mrc.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, and National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Trender Gerhard, Iris" sort="Trender Gerhard, Iris" uniqKey="Trender Gerhard I" first="Iris" last="Trender-Gerhard">Iris Trender-Gerhard</name></author><author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P" last="Quinn">Niall P. Quinn</name></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P" last="Bhatia">Kailash P. Bhatia</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Basal Ganglia (physiopathology)</term><term>Basal Ganglia (radionuclide imaging)</term><term>Brain Stem (physiopathology)</term><term>Brain Stem (radionuclide imaging)</term><term>Carbon Radioisotopes (diagnostic use)</term><term>Cell Death (physiology)</term><term>Female</term><term>Frontal Lobe (physiopathology)</term><term>Frontal Lobe (radionuclide imaging)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Isoquinolines (diagnostic use)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Microglia (physiology)</term><term>Microglia (radionuclide imaging)</term><term>Middle Aged</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Neurodegenerative Diseases (radionuclide imaging)</term><term>Neurons (physiology)</term><term>Receptors, GABA-A (physiology)</term><term>Reference Values</term><term>Stereoisomerism</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Supranuclear Palsy, Progressive (radionuclide imaging)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Carbon Radioisotopes</term><term>Isoquinolines</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Death</term><term>Microglia</term><term>Neurons</term><term>Receptors, GABA-A</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Brain Stem</term><term>Frontal Lobe</term><term>Neurodegenerative Diseases</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Basal Ganglia</term><term>Brain Stem</term><term>Frontal Lobe</term><term>Microglia</term><term>Neurodegenerative Diseases</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term><term>Stereoisomerism</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) is a neurodegenerative disease presenting with voluntary gaze difficulties, early falls, and Parkinsonism. Neuronal loss, associated with intracellular neurofibrillary tangles and activated microglia, is found targeting the basal ganglia, brainstem nuclei, and frontal cortex. [11C](R)-PK11195 PET is a marker of peripheral benzodiazepine binding sites (PBBS) expressed by activated microglia. We have used [11C](R)-PK11195 PET to demonstrate in vivo the degree and distribution of the glial response to the degenerative process in four patients with PSP. Compared to normal age-matched controls, the PSP patient group showed significantly increased mean [11C](R)-PK11195 binding in the basal ganglia, midbrain, the frontal lobe, and the cerebellum. Two of the patients were rescanned after 6 to 10 months and during that time the level of microglial activation remained stable. [11C](R)-PK11195 PET reveals a pattern of increased microglial activation in PSP patients involving cortical and subcortical regions that corresponds well with the known distribution of neuropathological changes. [11C](R)-PK11195 PET, therefore, may help in characterizing in vivo the underlying disease activity in PSP.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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