Depressive symptoms and life satisfaction in patients with multiple system atrophy.
Identifieur interne : 001202 ( Ncbi/Curation ); précédent : 001201; suivant : 001203Depressive symptoms and life satisfaction in patients with multiple system atrophy.
Auteurs : Lisa M. Benrud-Larson [États-Unis] ; Paola Sandroni ; Anette Schrag ; Phillip A. LowSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Aged, Blood Pressure (physiology), Chi-Square Distribution, Comorbidity, Demography, Depression (epidemiology), Depression (etiology), Female, Heart Rate (physiology), Humans, Male, Middle Aged, Multiple System Atrophy (epidemiology), Multiple System Atrophy (physiopathology), Multiple System Atrophy (psychology), Pain Measurement (methods), Personal Satisfaction, Personality Inventory, Regression Analysis.
- MESH :
- epidemiology : Depression, Multiple System Atrophy.
- etiology : Depression.
- methods : Pain Measurement.
- physiology : Blood Pressure, Heart Rate.
- physiopathology : Multiple System Atrophy.
- psychology : Multiple System Atrophy.
- Aged, Chi-Square Distribution, Comorbidity, Demography, Female, Humans, Male, Middle Aged, Personal Satisfaction, Personality Inventory, Regression Analysis.
Abstract
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by extrapyramidal signs, prominent autonomic failure, and a poor prognosis. In the absence of restorative treatment, management is aimed at improving quality of life. Little is known about modifiable factors, such as depression, that may affect quality of life in MSA. The present study investigated the rate of depressive symptoms and their relationship to life satisfaction in patients with MSA. Ninety-nine patients with MSA (54% women; mean age, 67.8 +/- 8.8) completed measures of depressive symptoms, life satisfaction, physical function, and disease and demographic factors. Objective autonomic indices were abstracted from the medical chart. Participants reported a high rate of depressive symptoms, with 39% endorsing moderate to severe depressive symptoms on the Beck Depression Inventory (BDI > or = 7). Reported life satisfaction was low, with a mean of 38.8 on a 100-point visual analogue scale (0 = Extremely Dissatisfied, 100 = Extremely Satisfied). The SF-36 Physical Component Scale was approximately 1.5 standard deviations below the mean of a normative sample of healthy adults the same age. Regression analysis revealed that autonomic disease parameters accounted for 22% of the variance in life satisfaction. Physical function did not account for any additional variance; however, depressive symptoms accounted for an additional 15%. Depressive symptoms are common, often severe, and an important determinant of life satisfaction in patients with MSA. Adequate treatment of comorbid depression may improve quality of life in this population, despite the presence of other debilitating deficits.
DOI: 10.1002/mds.20450
PubMed: 15782421
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pubmed:15782421Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Depressive symptoms and life satisfaction in patients with multiple system atrophy.</title><author><name sortKey="Benrud Larson, Lisa M" sort="Benrud Larson, Lisa M" uniqKey="Benrud Larson L" first="Lisa M" last="Benrud-Larson">Lisa M. Benrud-Larson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55095, USA. benru006@umn.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55095</wicri:regionArea><wicri:noRegion>Minnesota 55095</wicri:noRegion></affiliation></author><author><name sortKey="Sandroni, Paola" sort="Sandroni, Paola" uniqKey="Sandroni P" first="Paola" last="Sandroni">Paola Sandroni</name></author><author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name></author><author><name sortKey="Low, Phillip A" sort="Low, Phillip A" uniqKey="Low P" first="Phillip A" last="Low">Phillip A. Low</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20450</idno><idno type="RBID">pubmed:15782421</idno><idno type="pmid">15782421</idno><idno type="wicri:Area/PubMed/Corpus">003099</idno><idno type="wicri:Area/PubMed/Curation">003099</idno><idno type="wicri:Area/PubMed/Checkpoint">003171</idno><idno type="wicri:Area/Ncbi/Merge">001202</idno><idno type="wicri:Area/Ncbi/Curation">001202</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Depressive symptoms and life satisfaction in patients with multiple system atrophy.</title><author><name sortKey="Benrud Larson, Lisa M" sort="Benrud Larson, Lisa M" uniqKey="Benrud Larson L" first="Lisa M" last="Benrud-Larson">Lisa M. Benrud-Larson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55095, USA. benru006@umn.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55095</wicri:regionArea><wicri:noRegion>Minnesota 55095</wicri:noRegion></affiliation></author><author><name sortKey="Sandroni, Paola" sort="Sandroni, Paola" uniqKey="Sandroni P" first="Paola" last="Sandroni">Paola Sandroni</name></author><author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name></author><author><name sortKey="Low, Phillip A" sort="Low, Phillip A" uniqKey="Low P" first="Phillip A" last="Low">Phillip A. Low</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blood Pressure (physiology)</term><term>Chi-Square Distribution</term><term>Comorbidity</term><term>Demography</term><term>Depression (epidemiology)</term><term>Depression (etiology)</term><term>Female</term><term>Heart Rate (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (epidemiology)</term><term>Multiple System Atrophy (physiopathology)</term><term>Multiple System Atrophy (psychology)</term><term>Pain Measurement (methods)</term><term>Personal Satisfaction</term><term>Personality Inventory</term><term>Regression Analysis</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Pain Measurement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term><term>Heart Rate</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Chi-Square Distribution</term><term>Comorbidity</term><term>Demography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Personal Satisfaction</term><term>Personality Inventory</term><term>Regression Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by extrapyramidal signs, prominent autonomic failure, and a poor prognosis. In the absence of restorative treatment, management is aimed at improving quality of life. Little is known about modifiable factors, such as depression, that may affect quality of life in MSA. The present study investigated the rate of depressive symptoms and their relationship to life satisfaction in patients with MSA. Ninety-nine patients with MSA (54% women; mean age, 67.8 +/- 8.8) completed measures of depressive symptoms, life satisfaction, physical function, and disease and demographic factors. Objective autonomic indices were abstracted from the medical chart. Participants reported a high rate of depressive symptoms, with 39% endorsing moderate to severe depressive symptoms on the Beck Depression Inventory (BDI > or = 7). Reported life satisfaction was low, with a mean of 38.8 on a 100-point visual analogue scale (0 = Extremely Dissatisfied, 100 = Extremely Satisfied). The SF-36 Physical Component Scale was approximately 1.5 standard deviations below the mean of a normative sample of healthy adults the same age. Regression analysis revealed that autonomic disease parameters accounted for 22% of the variance in life satisfaction. Physical function did not account for any additional variance; however, depressive symptoms accounted for an additional 15%. Depressive symptoms are common, often severe, and an important determinant of life satisfaction in patients with MSA. Adequate treatment of comorbid depression may improve quality of life in this population, despite the presence of other debilitating deficits.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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