[18F]FDOPA PET and clinical features in parkinsonism due to manganism.
Identifieur interne : 001139 ( Ncbi/Curation ); précédent : 001138; suivant : 001140[18F]FDOPA PET and clinical features in parkinsonism due to manganism.
Auteurs : Brad A. Racette [États-Unis] ; Jo Ann Antenor ; Lori Mcgee-Minnich ; Stephen M. Moerlein ; Tom O. Videen ; Vikas Kotagal ; Joel S. PerlmutterSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Antiparkinson Agents (therapeutic use), Brain (metabolism), Carbidopa (therapeutic use), Drug Combinations, Female, Fluorodeoxyglucose F18 (diagnostic use), Gait, Humans, Levodopa (therapeutic use), Magnetic Resonance Imaging, Manganese Poisoning (blood), Manganese Poisoning (complications), Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (etiology), Parkinson Disease (pathology), Positron-Emission Tomography, Radiopharmaceuticals (diagnostic use).
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- chemical , therapeutic use : Antiparkinson Agents, Carbidopa, Levodopa.
- blood : Manganese Poisoning.
- complications : Manganese Poisoning.
- drug therapy : Parkinson Disease.
- etiology : Parkinson Disease.
- metabolism : Brain.
- pathology : Parkinson Disease.
- Adult, Drug Combinations, Female, Gait, Humans, Magnetic Resonance Imaging, Middle Aged, Positron-Emission Tomography.
Abstract
Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6-[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1-weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese-associated parkinsonism may overlap with that of PD.
DOI: 10.1002/mds.20381
PubMed: 15648057
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Racette</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. racetteb@neuro.wustl.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110</wicri:regionArea><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Antenor, Jo Ann" sort="Antenor, Jo Ann" uniqKey="Antenor J" first="Jo Ann" last="Antenor">Jo Ann Antenor</name></author><author><name sortKey="Mcgee Minnich, Lori" sort="Mcgee Minnich, Lori" uniqKey="Mcgee Minnich L" first="Lori" last="Mcgee-Minnich">Lori Mcgee-Minnich</name></author><author><name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M" last="Moerlein">Stephen M. Moerlein</name></author><author><name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O" last="Videen">Tom O. Videen</name></author><author><name sortKey="Kotagal, Vikas" sort="Kotagal, Vikas" uniqKey="Kotagal V" first="Vikas" last="Kotagal">Vikas Kotagal</name></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. 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Racette</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. racetteb@neuro.wustl.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110</wicri:regionArea><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Antenor, Jo Ann" sort="Antenor, Jo Ann" uniqKey="Antenor J" first="Jo Ann" last="Antenor">Jo Ann Antenor</name></author><author><name sortKey="Mcgee Minnich, Lori" sort="Mcgee Minnich, Lori" uniqKey="Mcgee Minnich L" first="Lori" last="Mcgee-Minnich">Lori Mcgee-Minnich</name></author><author><name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M" last="Moerlein">Stephen M. Moerlein</name></author><author><name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O" last="Videen">Tom O. Videen</name></author><author><name sortKey="Kotagal, Vikas" sort="Kotagal, Vikas" uniqKey="Kotagal V" first="Vikas" last="Kotagal">Vikas Kotagal</name></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antiparkinson Agents (therapeutic use)</term><term>Brain (metabolism)</term><term>Carbidopa (therapeutic use)</term><term>Drug Combinations</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Gait</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Magnetic Resonance Imaging</term><term>Manganese Poisoning (blood)</term><term>Manganese Poisoning (complications)</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (pathology)</term><term>Positron-Emission Tomography</term><term>Radiopharmaceuticals (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Manganese Poisoning</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Manganese Poisoning</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Drug Combinations</term><term>Female</term><term>Gait</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term><term>Positron-Emission Tomography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6-[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1-weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese-associated parkinsonism may overlap with that of PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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