Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia.
Identifieur interne : 001136 ( Ncbi/Curation ); précédent : 001135; suivant : 001137Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia.
Auteurs : Carme Junqué [Espagne] ; Blanca Ramírez-Ruiz ; Eduardo Tolosa ; Christopher Summerfield ; María-José Martí ; Pau Pastor ; Beatriz G Mez-Ans N ; José Ma MercaderSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Amygdala (pathology), Dementia (complications), Dementia (diagnosis), Diagnostic and Statistical Manual of Mental Disorders, Female, Hippocampus (pathology), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnosis), Severity of Illness Index.
- MESH :
- complications : Dementia, Parkinson Disease.
- diagnosis : Dementia, Parkinson Disease.
- pathology : Amygdala, Hippocampus.
- Aged, Aged, 80 and over, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.
Abstract
Parkinson's disease (PD) involves neuropathological changes in the limbic system that lead to neuronal loss and volumetric reductions of several nuclei. We investigated possible volumetric reductions of the amygdala and hippocampus associated to PD. We carried out magnetic resonance imaging (MRI) volumetric studies in 16 patients with PD and dementia (PDD), 16 patients with PD without dementia (PD), and 16 healthy subjects. The general analysis of variance (ANOVA) showed a significant group effect (for the amygdala, P = 0.01; for the hippocampus, P = 0.005). A post-hoc test demonstrated that the differences were due to PDD and control group comparisons for the amygdala (P = 0.008) and for the hippocampus (P = 0.004). In nondemented PD subjects, we observed an 11% reduction in the amygdala and a 10% reduction in the hippocampus compared with that in controls. In summary, demented PD patients have clear amygdalar and hippocampal atrophy that remains statistically significant after controlling for global cerebral atrophy. Nondemented PD patients also showed a degree of volumetric reduction in these structures although the differences were not statistically significant.
DOI: 10.1002/mds.20371
PubMed: 15645532
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uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Summerfield, Christopher" sort="Summerfield, Christopher" uniqKey="Summerfield C" first="Christopher" last="Summerfield">Christopher Summerfield</name></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="María-José" last="Martí">María-José Martí</name></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name></author><author><name sortKey="G Mez Ans N, Beatriz" sort="G Mez Ans N, Beatriz" uniqKey="G Mez Ans N B" first="Beatriz" last="G Mez-Ans N">Beatriz G Mez-Ans N</name></author><author><name sortKey="Mercader, Jose Ma" sort="Mercader, Jose Ma" uniqKey="Mercader J" first="José Ma" last="Mercader">José Ma Mercader</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20371</idno><idno 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type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ramirez Ruiz, Blanca" sort="Ramirez Ruiz, Blanca" uniqKey="Ramirez Ruiz B" first="Blanca" last="Ramírez-Ruiz">Blanca Ramírez-Ruiz</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Summerfield, Christopher" sort="Summerfield, Christopher" uniqKey="Summerfield C" first="Christopher" last="Summerfield">Christopher Summerfield</name></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="María-José" last="Martí">María-José Martí</name></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name></author><author><name sortKey="G Mez Ans N, Beatriz" sort="G Mez Ans N, Beatriz" uniqKey="G Mez Ans N B" first="Beatriz" last="G Mez-Ans N">Beatriz G Mez-Ans N</name></author><author><name sortKey="Mercader, Jose Ma" sort="Mercader, Jose Ma" uniqKey="Mercader J" first="José Ma" last="Mercader">José Ma Mercader</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Amygdala (pathology)</term><term>Dementia (complications)</term><term>Dementia (diagnosis)</term><term>Diagnostic and Statistical Manual of Mental Disorders</term><term>Female</term><term>Hippocampus (pathology)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Amygdala</term><term>Hippocampus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Diagnostic and Statistical Manual of Mental Disorders</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) involves neuropathological changes in the limbic system that lead to neuronal loss and volumetric reductions of several nuclei. We investigated possible volumetric reductions of the amygdala and hippocampus associated to PD. We carried out magnetic resonance imaging (MRI) volumetric studies in 16 patients with PD and dementia (PDD), 16 patients with PD without dementia (PD), and 16 healthy subjects. The general analysis of variance (ANOVA) showed a significant group effect (for the amygdala, P = 0.01; for the hippocampus, P = 0.005). A post-hoc test demonstrated that the differences were due to PDD and control group comparisons for the amygdala (P = 0.008) and for the hippocampus (P = 0.004). In nondemented PD subjects, we observed an 11% reduction in the amygdala and a 10% reduction in the hippocampus compared with that in controls. In summary, demented PD patients have clear amygdalar and hippocampal atrophy that remains statistically significant after controlling for global cerebral atrophy. Nondemented PD patients also showed a degree of volumetric reduction in these structures although the differences were not statistically significant.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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