Levodopa-dyskinesia incidence by age of Parkinson's disease onset.
Identifieur interne : 001105 ( Ncbi/Curation ); précédent : 001104; suivant : 001106Levodopa-dyskinesia incidence by age of Parkinson's disease onset.
Auteurs : Neeraj Kumar [États-Unis] ; Jay A. Van Gerpen ; James H. Bower ; J Eric AhlskogSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Cohort Studies, Dyskinesia, Drug-Induced (etiology), Female, Humans, Incidence, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Retrospective Studies.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- epidemiology : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- Adult, Age of Onset, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Incidence, Male, Middle Aged, Retrospective Studies.
Abstract
We assessed the 5-year risk of levodopa-induced dyskinesias by age of Parkinson's disease (PD) onset in a population-based cohort. The medical records linkage system of the Rochester Epidemiology project was used to identify residents of Olmsted County, Minnesota, with incident PD for the period 1976 through 1990. In this population-based study, the 5-year dyskinesia incidence declined with age. With PD onset after 70 years of age, the incidence was 16%. With onset from 40 to 59 years of age, the incidence was higher at 50%. These incidence data may overestimate the functional importance, because patients with minimal or reversible dyskinesias were counted.
DOI: 10.1002/mds.20360
PubMed: 15580606
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pubmed:15580606Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Levodopa-dyskinesia incidence by age of Parkinson's disease onset.</title><author><name sortKey="Kumar, Neeraj" sort="Kumar, Neeraj" uniqKey="Kumar N" first="Neeraj" last="Kumar">Neeraj Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. kumar.neeraj@mayo.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Van Gerpen, Jay A" sort="Van Gerpen, Jay A" uniqKey="Van Gerpen J" first="Jay A" last="Van Gerpen">Jay A. Van Gerpen</name></author><author><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H" last="Bower">James H. Bower</name></author><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J Eric" last="Ahlskog">J Eric Ahlskog</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20360</idno><idno type="RBID">pubmed:15580606</idno><idno type="pmid">15580606</idno><idno type="wicri:Area/PubMed/Corpus">003196</idno><idno type="wicri:Area/PubMed/Curation">003196</idno><idno type="wicri:Area/PubMed/Checkpoint">003077</idno><idno type="wicri:Area/Ncbi/Merge">001105</idno><idno type="wicri:Area/Ncbi/Curation">001105</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Levodopa-dyskinesia incidence by age of Parkinson's disease onset.</title><author><name sortKey="Kumar, Neeraj" sort="Kumar, Neeraj" uniqKey="Kumar N" first="Neeraj" last="Kumar">Neeraj Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. kumar.neeraj@mayo.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Van Gerpen, Jay A" sort="Van Gerpen, Jay A" uniqKey="Van Gerpen J" first="Jay A" last="Van Gerpen">Jay A. Van Gerpen</name></author><author><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H" last="Bower">James H. Bower</name></author><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J Eric" last="Ahlskog">J Eric Ahlskog</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (adverse effects)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Cohort Studies</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Levodopa (adverse effects)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the 5-year risk of levodopa-induced dyskinesias by age of Parkinson's disease (PD) onset in a population-based cohort. The medical records linkage system of the Rochester Epidemiology project was used to identify residents of Olmsted County, Minnesota, with incident PD for the period 1976 through 1990. In this population-based study, the 5-year dyskinesia incidence declined with age. With PD onset after 70 years of age, the incidence was 16%. With onset from 40 to 59 years of age, the incidence was higher at 50%. These incidence data may overestimate the functional importance, because patients with minimal or reversible dyskinesias were counted.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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