Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease.
Identifieur interne : 001102 ( Ncbi/Curation ); précédent : 001101; suivant : 001103Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease.
Auteurs : Adrian P. Fawcett [Canada] ; Elena Moro ; Anthony E. Lang ; Andres M. Lozano ; William D. HutchisonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Basal Ganglia (physiopathology), Deep Brain Stimulation (instrumentation), Functional Laterality (physiology), Globus Pallidus (physiology), Globus Pallidus (surgery), Humans, Huntington Disease (diagnosis), Huntington Disease (physiopathology), Huntington Disease (surgery), Male, Neurosurgical Procedures (methods), Oculomotor Nerve (physiopathology), Saccades (physiology), Time Factors.
- MESH :
- diagnosis : Huntington Disease.
- instrumentation : Deep Brain Stimulation.
- methods : Neurosurgical Procedures.
- physiology : Functional Laterality, Globus Pallidus, Saccades.
- physiopathology : Basal Ganglia, Huntington Disease, Oculomotor Nerve.
- surgery : Globus Pallidus, Huntington Disease.
- Adult, Humans, Male, Time Factors.
Abstract
Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is being evaluated as a potential new therapy for patients with Huntington's disease (HD). In addition to skeletal movement disorders, HD patients have difficulty initiating voluntary saccades and have difficulty in suppressing rapid saccades toward newly appearing stimuli. We measured several saccade parameters in an HD patient who had marked improvement of clinical symptoms with bilateral GPi DBS to determine whether oculomotor performance improved in parallel with clinical scores. Oculomotor performance was assessed using three testing paradigms: pro-saccades, anti-saccades, and memory-guided saccades. The data from the HD patient was also compared to that of two healthy controls. Pallidal DBS decreased pro-saccade latency, total movement time, and the number of correctly executed trials, as well as increasing saccade gain. Memory-saccade performance was negatively affected with stimulation: saccade gain decreased, latency increased, and the patient's ability to suppress unwanted saccades decreased with stimulation. Our data demonstrate a task-specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control.
DOI: 10.1002/mds.20356
PubMed: 15580556
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Fawcett</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20356</idno><idno type="RBID">pubmed:15580556</idno><idno type="pmid">15580556</idno><idno type="wicri:Area/PubMed/Corpus">003199</idno><idno type="wicri:Area/PubMed/Curation">003199</idno><idno type="wicri:Area/PubMed/Checkpoint">003025</idno><idno type="wicri:Area/Ncbi/Merge">001102</idno><idno type="wicri:Area/Ncbi/Curation">001102</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease.</title><author><name sortKey="Fawcett, Adrian P" sort="Fawcett, Adrian P" uniqKey="Fawcett A" first="Adrian P" last="Fawcett">Adrian P. Fawcett</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Basal Ganglia (physiopathology)</term><term>Deep Brain Stimulation (instrumentation)</term><term>Functional Laterality (physiology)</term><term>Globus Pallidus (physiology)</term><term>Globus Pallidus (surgery)</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (physiopathology)</term><term>Huntington Disease (surgery)</term><term>Male</term><term>Neurosurgical Procedures (methods)</term><term>Oculomotor Nerve (physiopathology)</term><term>Saccades (physiology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Globus Pallidus</term><term>Saccades</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Huntington Disease</term><term>Oculomotor Nerve</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Male</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is being evaluated as a potential new therapy for patients with Huntington's disease (HD). In addition to skeletal movement disorders, HD patients have difficulty initiating voluntary saccades and have difficulty in suppressing rapid saccades toward newly appearing stimuli. We measured several saccade parameters in an HD patient who had marked improvement of clinical symptoms with bilateral GPi DBS to determine whether oculomotor performance improved in parallel with clinical scores. Oculomotor performance was assessed using three testing paradigms: pro-saccades, anti-saccades, and memory-guided saccades. The data from the HD patient was also compared to that of two healthy controls. Pallidal DBS decreased pro-saccade latency, total movement time, and the number of correctly executed trials, as well as increasing saccade gain. Memory-saccade performance was negatively affected with stimulation: saccade gain decreased, latency increased, and the patient's ability to suppress unwanted saccades decreased with stimulation. Our data demonstrate a task-specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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