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An urge to move with L-thyroxine: clinical, biochemical, and polysomnographic correlation.

Identifieur interne : 000F50 ( Ncbi/Curation ); précédent : 000F49; suivant : 000F51

An urge to move with L-thyroxine: clinical, biochemical, and polysomnographic correlation.

Auteurs : Eng-King Tan [Singapour] ; Su-Chin Ho ; Leonard Koh ; Ratnagopal Pavanni

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.

RBID : pubmed:15378680

English descriptors

KwdEn :
- Ferritins (blood), Humans, Hypothyroidism (drug therapy), Iron (therapeutic use), Male, Middle Aged, Neurologic Examination, Polysomnography, Restless Legs Syndrome (chemically induced), Restless Legs Syndrome (diagnosis), Risk Factors, Thyroid Function Tests, Thyroiditis, Autoimmune (drug therapy), Thyroxine (adverse effects), Thyroxine (therapeutic use).
MESH :
- chemical , adverse effects : Thyroxine.
- chemical , blood : Ferritins.
- chemically induced : Restless Legs Syndrome.
- diagnosis : Restless Legs Syndrome.
- drug therapy : Hypothyroidism, Thyroiditis, Autoimmune.
- chemical , therapeutic use : Iron, Thyroxine.
- Humans, Male, Middle Aged, Neurologic Examination, Polysomnography, Risk Factors, Thyroid Function Tests.

Abstract

We report on the cause and effect relationship of restless legs syndrome (RLS) with L-thyroxine treatment in a hypothyroid patient with low serum ferritin. Upon challenge and withdrawal of L-thyroxine, there was a significant change in the International Restless Legs Syndrome Study Group severity score (26/40 to 6/40), the periodic limb movements (PMLS) index (20/hour to 10/hour), the number of arousals due to PLMS (59 to 22), sleep efficiency (74 to 85%), and biochemical parameters. RLS symptoms can complicate thyroxine replacement in at-risk hypothyroid patients with low serum ferritin. Early diagnosis and iron replacement could significantly reduce patient morbidity.

DOI: 10.1002/mds.20219
PubMed: 15378680

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pubmed:15378680

Le document en format XML

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<author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Neurology, Singapore General Hospital</wicri:regionArea>
<wicri:noRegion>Singapore General Hospital</wicri:noRegion>
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<author><name sortKey="Ho, Su Chin" sort="Ho, Su Chin" uniqKey="Ho S" first="Su-Chin" last="Ho">Su-Chin Ho</name>
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<author><name sortKey="Koh, Leonard" sort="Koh, Leonard" uniqKey="Koh L" first="Leonard" last="Koh">Leonard Koh</name>
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<author><name sortKey="Pavanni, Ratnagopal" sort="Pavanni, Ratnagopal" uniqKey="Pavanni R" first="Ratnagopal" last="Pavanni">Ratnagopal Pavanni</name>
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<author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
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<author><name sortKey="Pavanni, Ratnagopal" sort="Pavanni, Ratnagopal" uniqKey="Pavanni R" first="Ratnagopal" last="Pavanni">Ratnagopal Pavanni</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ferritins (blood)</term>
<term>Humans</term>
<term>Hypothyroidism (drug therapy)</term>
<term>Iron (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurologic Examination</term>
<term>Polysomnography</term>
<term>Restless Legs Syndrome (chemically induced)</term>
<term>Restless Legs Syndrome (diagnosis)</term>
<term>Risk Factors</term>
<term>Thyroid Function Tests</term>
<term>Thyroiditis, Autoimmune (drug therapy)</term>
<term>Thyroxine (adverse effects)</term>
<term>Thyroxine (therapeutic use)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Thyroxine</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ferritins</term>
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<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypothyroidism</term>
<term>Thyroiditis, Autoimmune</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Iron</term>
<term>Thyroxine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurologic Examination</term>
<term>Polysomnography</term>
<term>Risk Factors</term>
<term>Thyroid Function Tests</term>
</keywords>
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<front><div type="abstract" xml:lang="en">We report on the cause and effect relationship of restless legs syndrome (RLS) with L-thyroxine treatment in a hypothyroid patient with low serum ferritin. Upon challenge and withdrawal of L-thyroxine, there was a significant change in the International Restless Legs Syndrome Study Group severity score (26/40 to 6/40), the periodic limb movements (PMLS) index (20/hour to 10/hour), the number of arousals due to PLMS (59 to 22), sleep efficiency (74 to 85%), and biochemical parameters. RLS symptoms can complicate thyroxine replacement in at-risk hypothyroid patients with low serum ferritin. Early diagnosis and iron replacement could significantly reduce patient morbidity.</div>
</front>
</TEI>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

An urge to move with L-thyroxine: clinical, biochemical, and polysomnographic correlation.

An urge to move with L-thyroxine: clinical, biochemical, and polysomnographic correlation.

Source :

English descriptors

Abstract

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Le document en format XML

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Pour générer des pages wiki