Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease.
Identifieur interne : 000A99 ( Ncbi/Curation ); précédent : 000A98; suivant : 000B00Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease.
Auteurs : Philip V. Theodosopoulos [États-Unis] ; William J. Marks ; Chadwick Christine ; Philip A. StarrSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Action Potentials (physiology), Arm (innervation), Brain Mapping, Dominance, Cerebral (physiology), Electric Stimulation Therapy, Electrodes, Implanted, Humans, Image Processing, Computer-Assisted, Joints (innervation), Leg (innervation), Magnetic Resonance Imaging, Microelectrodes, Muscle, Skeletal (innervation), Neurologic Examination, Neuronavigation, Neurons (classification), Neurons (physiology), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Range of Motion, Articular (physiology), Substantia Nigra (physiopathology), Subthalamic Nucleus (physiopathology), Subthalamic Nucleus (surgery), Treatment Outcome.
- MESH :
- classification : Neurons.
- innervation : Arm, Joints, Leg, Muscle, Skeletal.
- physiology : Action Potentials, Dominance, Cerebral, Neurons, Range of Motion, Articular.
- physiopathology : Parkinson Disease, Substantia Nigra, Subthalamic Nucleus.
- surgery : Parkinson Disease, Subthalamic Nucleus.
- Brain Mapping, Electric Stimulation Therapy, Electrodes, Implanted, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Microelectrodes, Neurologic Examination, Neuronavigation, Treatment Outcome.
Abstract
The subthalamic nucleus (STN) is an emerging target for deep brain stimulator (DBS) implantation for the treatment of advanced Parkinson's disease (PD). Understanding the somatotopic organization of the STN is important for surgical navigation within the nucleus. We analyzed intraoperative data obtained during 54 procedures for the implantation of STN stimulators to assess the locations of movement-related cells. Cells were considered movement-related if they exhibited modulation of the cell discharge during passive movement of the contralateral upper or lower extremity. Microelectrode track reconstructions were plotted on a human brain atlas, using the location of the DBS electrode from postoperative magnetic resonance images as a registration mark in reconstructing microelectrode track locations. Movement-related cells were predominantly located in the dorsal part of the nucleus. The majority of the cells were related to proximal joint manipulation. Arm-related cells were located laterally and at the rostral and caudal poles, whereas leg-related cells were located medially and centrally. The finding of three or more leg-related cells on a given microelectrode track was predictive of a medial localization within the motor area. Our findings are consistent with the small number of published studies on STN somatopy in the human and the nonhuman primate.
DOI: 10.1002/mds.10446
PubMed: 12815658
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease.</title><author><name sortKey="Theodosopoulos, Philip V" sort="Theodosopoulos, Philip V" uniqKey="Theodosopoulos P" first="Philip V" last="Theodosopoulos">Philip V. Theodosopoulos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, University of California, San Francisco, California 94143, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of California, San Francisco, California 94143</wicri:regionArea><wicri:noRegion>California 94143</wicri:noRegion></affiliation></author><author><name sortKey="Marks, William J" sort="Marks, William J" uniqKey="Marks W" first="William J" last="Marks">William J. Marks</name></author><author><name sortKey="Christine, Chadwick" sort="Christine, Chadwick" uniqKey="Christine C" first="Chadwick" last="Christine">Chadwick Christine</name></author><author><name sortKey="Starr, Philip A" sort="Starr, Philip A" uniqKey="Starr P" first="Philip A" last="Starr">Philip A. Starr</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12815658</idno><idno type="pmid">12815658</idno><idno type="doi">10.1002/mds.10446</idno><idno type="wicri:Area/PubMed/Corpus">003752</idno><idno type="wicri:Area/PubMed/Curation">003752</idno><idno type="wicri:Area/PubMed/Checkpoint">003742</idno><idno type="wicri:Area/Ncbi/Merge">000A99</idno><idno type="wicri:Area/Ncbi/Curation">000A99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease.</title><author><name sortKey="Theodosopoulos, Philip V" sort="Theodosopoulos, Philip V" uniqKey="Theodosopoulos P" first="Philip V" last="Theodosopoulos">Philip V. Theodosopoulos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, University of California, San Francisco, California 94143, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of California, San Francisco, California 94143</wicri:regionArea><wicri:noRegion>California 94143</wicri:noRegion></affiliation></author><author><name sortKey="Marks, William J" sort="Marks, William J" uniqKey="Marks W" first="William J" last="Marks">William J. Marks</name></author><author><name sortKey="Christine, Chadwick" sort="Christine, Chadwick" uniqKey="Christine C" first="Chadwick" last="Christine">Chadwick Christine</name></author><author><name sortKey="Starr, Philip A" sort="Starr, Philip A" uniqKey="Starr P" first="Philip A" last="Starr">Philip A. Starr</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (physiology)</term><term>Arm (innervation)</term><term>Brain Mapping</term><term>Dominance, Cerebral (physiology)</term><term>Electric Stimulation Therapy</term><term>Electrodes, Implanted</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Joints (innervation)</term><term>Leg (innervation)</term><term>Magnetic Resonance Imaging</term><term>Microelectrodes</term><term>Muscle, Skeletal (innervation)</term><term>Neurologic Examination</term><term>Neuronavigation</term><term>Neurons (classification)</term><term>Neurons (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Range of Motion, Articular (physiology)</term><term>Substantia Nigra (physiopathology)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic Nucleus (surgery)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Arm</term><term>Joints</term><term>Leg</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Action Potentials</term><term>Dominance, Cerebral</term><term>Neurons</term><term>Range of Motion, Articular</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Brain Mapping</term><term>Electric Stimulation Therapy</term><term>Electrodes, Implanted</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Microelectrodes</term><term>Neurologic Examination</term><term>Neuronavigation</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) is an emerging target for deep brain stimulator (DBS) implantation for the treatment of advanced Parkinson's disease (PD). Understanding the somatotopic organization of the STN is important for surgical navigation within the nucleus. We analyzed intraoperative data obtained during 54 procedures for the implantation of STN stimulators to assess the locations of movement-related cells. Cells were considered movement-related if they exhibited modulation of the cell discharge during passive movement of the contralateral upper or lower extremity. Microelectrode track reconstructions were plotted on a human brain atlas, using the location of the DBS electrode from postoperative magnetic resonance images as a registration mark in reconstructing microelectrode track locations. Movement-related cells were predominantly located in the dorsal part of the nucleus. The majority of the cells were related to proximal joint manipulation. Arm-related cells were located laterally and at the rostral and caudal poles, whereas leg-related cells were located medially and centrally. The finding of three or more leg-related cells on a given microelectrode track was predictive of a medial localization within the motor area. Our findings are consistent with the small number of published studies on STN somatopy in the human and the nonhuman primate.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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