Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's disease.
Identifieur interne : 000A31 ( Ncbi/Curation ); précédent : 000A30; suivant : 000A32Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's disease.
Auteurs : Peter Brown [Royaume-Uni]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Basal Ganglia (physiology), Basal Ganglia Diseases (diagnosis), Basal Ganglia Diseases (physiopathology), Basal Ganglia Diseases (surgery), Cortical Synchronization, Dopamine (physiology), Humans, Nerve Net (physiopathology), Nerve Net (surgery), Oscillometry, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Synaptic Transmission (physiology).
- MESH :
- chemical , physiology : Dopamine.
- diagnosis : Basal Ganglia Diseases, Parkinson Disease.
- physiology : Basal Ganglia, Synaptic Transmission.
- physiopathology : Basal Ganglia Diseases, Nerve Net, Parkinson Disease.
- surgery : Basal Ganglia Diseases, Nerve Net, Parkinson Disease.
- Cortical Synchronization, Humans, Oscillometry.
Abstract
Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an increase in the firing rate of neurones and a change in the pattern of synchronisation of discharges between neurones. Recent findings suggest the presence of two principal modes of synchronised activity within the human subthalamo-pallidal-thalamo-cortical circuit, at <30 Hz and >60 Hz. These oscillations are dynamically and systematically modulated by task, thereby suggesting a functional role in movement. More importantly, the two frequency modes are inversely affected by movement, consistent with opposing actions, and differentially expressed according to the prevailing level of dopaminergic activity. It is argued that the balance between these modes determines the effects of basal ganglia-thalamocortical projections on the motor areas of the cortex. The lower frequency oscillations facilitate slow idling rhythms in the motor areas of the cortex, whereas synchronisation at high frequency restores dynamic task-related cortical ensemble activity in the gamma band.
DOI: 10.1002/mds.10358
PubMed: 12671940
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pubmed:12671940Le document en format XML
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<author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name>
<affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Neurophysiology and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom. p.brown@ion.ucl.ac.uk</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Neurophysiology and Movement Disorders, Institute of Neurology, Queen Square, London</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's disease.</title>
<author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name>
<affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Neurophysiology and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom. p.brown@ion.ucl.ac.uk</nlm:affiliation>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Basal Ganglia Diseases (physiopathology)</term>
<term>Basal Ganglia Diseases (surgery)</term>
<term>Cortical Synchronization</term>
<term>Dopamine (physiology)</term>
<term>Humans</term>
<term>Nerve Net (physiopathology)</term>
<term>Nerve Net (surgery)</term>
<term>Oscillometry</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Synaptic Transmission (physiology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term>
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<term>Parkinson Disease</term>
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<term>Nerve Net</term>
<term>Parkinson Disease</term>
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<term>Nerve Net</term>
<term>Parkinson Disease</term>
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<term>Humans</term>
<term>Oscillometry</term>
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<front><div type="abstract" xml:lang="en">Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an increase in the firing rate of neurones and a change in the pattern of synchronisation of discharges between neurones. Recent findings suggest the presence of two principal modes of synchronised activity within the human subthalamo-pallidal-thalamo-cortical circuit, at <30 Hz and >60 Hz. These oscillations are dynamically and systematically modulated by task, thereby suggesting a functional role in movement. More importantly, the two frequency modes are inversely affected by movement, consistent with opposing actions, and differentially expressed according to the prevailing level of dopaminergic activity. It is argued that the balance between these modes determines the effects of basal ganglia-thalamocortical projections on the motor areas of the cortex. The lower frequency oscillations facilitate slow idling rhythms in the motor areas of the cortex, whereas synchronisation at high frequency restores dynamic task-related cortical ensemble activity in the gamma band.</div>
</front>
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