MovDisordV3, Ncbi, Curation, bibRecord, 000906

Freezing of gait in postmortem-confirmed atypical parkinsonism.

Identifieur interne : 000906 ( Ncbi/Curation ); précédent : 000905; suivant : 000907

Freezing of gait in postmortem-confirmed atypical parkinsonism.

Auteurs : Jörg Müller [Autriche] ; Klaus Seppi ; Nadia Stefanova ; Werner Poewe [Autriche] ; Irene Litvan ; Gregor K. Wenning

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.

RBID : pubmed:12360556

English descriptors

KwdEn :
- Aged, Basal Ganglia Diseases (pathology), Brain (pathology), Culture Techniques, Female, Gait Disorders, Neurologic (epidemiology), Gait Disorders, Neurologic (etiology), Humans, Lewy Body Disease (pathology), Male, Middle Aged, Multiple System Atrophy (pathology), Parkinsonian Disorders (complications), Parkinsonian Disorders (pathology).
MESH :
- complications : Parkinsonian Disorders.
- epidemiology : Gait Disorders, Neurologic.
- etiology : Gait Disorders, Neurologic.
- pathology : Basal Ganglia Diseases, Brain, Lewy Body Disease, Multiple System Atrophy, Parkinsonian Disorders.
- Aged, Culture Techniques, Female, Humans, Male, Middle Aged.

Abstract

The frequency and pathophysiology of freezing of gait (FoG) in atypical parkinsonism is unknown. We analysed the frequency of FoG in postmortem-confirmed atypical parkinsonian disorders (APD) comprising corticobasal degeneration (CBD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Sixty-six patients with pathologically confirmed APD (CBD, n = 13; DLB, n = 14; MSA, n = 15; PSP, n = 24) formed the basis for a multicenter clinicopathological study. Clinical features at first and last clinical visit were abstracted from patient records on standardized forms following strict instructions. At the first visit (median 36 months after symptom onset), 24% of APD had FoG (CBD, 8%; DLB, 21%; PSP, 25%; MSA, 40%). Logistic regression analysis showed a significant association of FoG and urinary incontinence (P = 0.04) at first visit. At last visit, 47% of APD had FoG (CBD, 25%; PSP, 53%; DLB, 54%; MSA, 54%). Clinicopathological correlation based on routine postmortem examination failed to identify a consistent neuropathological substrate of FoG. This study demonstrates that (1) FoG is common in APD, and (2) urinary incontinence is significantly associated with FoG in these disorders. Whether FoG and urinary incontinence share similar neuropathological substrates remains to be determined by future studies.

DOI: 10.1002/mds.10234
PubMed: 12360556

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pubmed:12360556

Le document en format XML

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<author><name sortKey="Muller, Jorg" sort="Muller, Jorg" uniqKey="Muller J" first="Jörg" last="Müller">Jörg Müller</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Innsbruck, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
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<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
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<author><name sortKey="Stefanova, Nadia" sort="Stefanova, Nadia" uniqKey="Stefanova N" first="Nadia" last="Stefanova">Nadia Stefanova</name>
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<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
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<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name>
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<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
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<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
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<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Female</term>
<term>Gait Disorders, Neurologic (epidemiology)</term>
<term>Gait Disorders, Neurologic (etiology)</term>
<term>Humans</term>
<term>Lewy Body Disease (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (pathology)</term>
<term>Parkinsonian Disorders (complications)</term>
<term>Parkinsonian Disorders (pathology)</term>
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<term>Brain</term>
<term>Lewy Body Disease</term>
<term>Multiple System Atrophy</term>
<term>Parkinsonian Disorders</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Culture Techniques</term>
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<front><div type="abstract" xml:lang="en">The frequency and pathophysiology of freezing of gait (FoG) in atypical parkinsonism is unknown. We analysed the frequency of FoG in postmortem-confirmed atypical parkinsonian disorders (APD) comprising corticobasal degeneration (CBD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Sixty-six patients with pathologically confirmed APD (CBD, n = 13; DLB, n = 14; MSA, n = 15; PSP, n = 24) formed the basis for a multicenter clinicopathological study. Clinical features at first and last clinical visit were abstracted from patient records on standardized forms following strict instructions. At the first visit (median 36 months after symptom onset), 24% of APD had FoG (CBD, 8%; DLB, 21%; PSP, 25%; MSA, 40%). Logistic regression analysis showed a significant association of FoG and urinary incontinence (P = 0.04) at first visit. At last visit, 47% of APD had FoG (CBD, 25%; PSP, 53%; DLB, 54%; MSA, 54%). Clinicopathological correlation based on routine postmortem examination failed to identify a consistent neuropathological substrate of FoG. This study demonstrates that (1) FoG is common in APD, and (2) urinary incontinence is significantly associated with FoG in these disorders. Whether FoG and urinary incontinence share similar neuropathological substrates remains to be determined by future studies.</div>
</front>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Freezing of gait in postmortem-confirmed atypical parkinsonism.

Freezing of gait in postmortem-confirmed atypical parkinsonism.

Source :

English descriptors

Abstract

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