Monosymptomatic resting tremor and Parkinson's disease: a multitracer positron emission tomographic study.
Identifieur interne : 000841 ( Ncbi/Curation ); précédent : 000840; suivant : 000842Monosymptomatic resting tremor and Parkinson's disease: a multitracer positron emission tomographic study.
Auteurs : Mehran Ghaemi [Allemagne] ; Jan Raethjen ; Rüdiger Hilker ; Jobst Rudolf ; Jan Sobesky ; Günther Deuschl ; Wolf-Dieter HeissSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- Adult, Aged, Brain (physiopathology), Brain (radionuclide imaging), Cerebellum (physiopathology), Cerebellum (radionuclide imaging), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Dominance, Cerebral (physiology), Energy Metabolism (physiology), Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Putamen (physiopathology), Putamen (radionuclide imaging), Raclopride (diagnostic use), Receptors, Dopamine D2 (physiology), Reference Values, Tomography, Emission-Computed (methods), Tremor (physiopathology), Tremor (radionuclide imaging), Up-Regulation (physiology).
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , diagnostic use : Dihydroxyphenylalanine, Fluorodeoxyglucose F18, Raclopride.
- methods : Tomography, Emission-Computed.
- physiology : Dominance, Cerebral, Energy Metabolism, Receptors, Dopamine D2, Up-Regulation.
- physiopathology : Brain, Cerebellum, Parkinson Disease, Putamen, Tremor.
- radionuclide imaging : Brain, Cerebellum, Parkinson Disease, Putamen, Tremor.
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Reference Values.
Abstract
We sought to elucidate the relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD). We studied eight mRT patients (mean Hoehn and Yahr [H&Y], 1.1 +/- 0.4), eight patients with PD (mean H&Y, 1.5 +/- 0.8), who showed all three classic parkinsonian symptoms, and seven age-matched healthy subjects. Subjects underwent cerebral magnetic resonance imaging (MRI) and multitracer positron emission tomography (PET) with 6-[(18)F]fluoro-L-dopa (F-dopa), [(18)F]fluorodeoxyglucose (FDG), and [(11)C]raclopride (RACLO). PD and mRT patients did not show significant differences in F-dopa-, RACLO-, or FDG-PET scans. In F-dopa- and RACLO-PET, significant differences between the pooled patient data and control subjects were found for the following regions: anterior and posterior putamen ipsilateral and contralateral to the more affected body side, and ipsilateral and contralateral putaminal gradients of the K(i) values. Furthermore, we found a difference for the normalized glucose values of the whole cerebellum between the control group (0.94 +/- 0.06) and PD patients (1.01 +/- 0.04; P < 0.05) but not for the mRT group (0.97 +/- 0.03). Our findings indicate that monosymptomatic resting tremor represents a phenotype of Parkinson's disease, with a nearly identical striatal dopaminergic deficit and postsynaptic D2-receptor upregulation in both patient groups. We suggest that the cerebellar metabolic hyperactivity in PD is closer related to akinesia and rigidity rather than to tremor.
DOI: 10.1002/mds.10125
PubMed: 12210876
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sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author><author><name sortKey="Rudolf, Jobst" sort="Rudolf, Jobst" uniqKey="Rudolf J" first="Jobst" last="Rudolf">Jobst Rudolf</name></author><author><name sortKey="Sobesky, Jan" sort="Sobesky, Jan" uniqKey="Sobesky J" first="Jan" last="Sobesky">Jan Sobesky</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12210876</idno><idno type="pmid">12210876</idno><idno type="doi">10.1002/mds.10125</idno><idno type="wicri:Area/PubMed/Corpus">003A10</idno><idno 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type="university">Université de Cologne</orgName></affiliation></author><author><name sortKey="Raethjen, Jan" sort="Raethjen, Jan" uniqKey="Raethjen J" first="Jan" last="Raethjen">Jan Raethjen</name></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author><author><name sortKey="Rudolf, Jobst" sort="Rudolf, Jobst" uniqKey="Rudolf J" first="Jobst" last="Rudolf">Jobst Rudolf</name></author><author><name sortKey="Sobesky, Jan" sort="Sobesky, Jan" uniqKey="Sobesky J" first="Jan" last="Sobesky">Jan Sobesky</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain (physiopathology)</term><term>Brain (radionuclide imaging)</term><term>Cerebellum (physiopathology)</term><term>Cerebellum (radionuclide imaging)</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (diagnostic use)</term><term>Dominance, Cerebral (physiology)</term><term>Energy Metabolism (physiology)</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Putamen (physiopathology)</term><term>Putamen (radionuclide imaging)</term><term>Raclopride (diagnostic use)</term><term>Receptors, Dopamine D2 (physiology)</term><term>Reference Values</term><term>Tomography, Emission-Computed (methods)</term><term>Tremor (physiopathology)</term><term>Tremor (radionuclide imaging)</term><term>Up-Regulation (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Dihydroxyphenylalanine</term><term>Fluorodeoxyglucose F18</term><term>Raclopride</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term><term>Energy Metabolism</term><term>Receptors, Dopamine D2</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Cerebellum</term><term>Parkinson Disease</term><term>Putamen</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Cerebellum</term><term>Parkinson Disease</term><term>Putamen</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We sought to elucidate the relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD). We studied eight mRT patients (mean Hoehn and Yahr [H&Y], 1.1 +/- 0.4), eight patients with PD (mean H&Y, 1.5 +/- 0.8), who showed all three classic parkinsonian symptoms, and seven age-matched healthy subjects. Subjects underwent cerebral magnetic resonance imaging (MRI) and multitracer positron emission tomography (PET) with 6-[(18)F]fluoro-L-dopa (F-dopa), [(18)F]fluorodeoxyglucose (FDG), and [(11)C]raclopride (RACLO). PD and mRT patients did not show significant differences in F-dopa-, RACLO-, or FDG-PET scans. In F-dopa- and RACLO-PET, significant differences between the pooled patient data and control subjects were found for the following regions: anterior and posterior putamen ipsilateral and contralateral to the more affected body side, and ipsilateral and contralateral putaminal gradients of the K(i) values. Furthermore, we found a difference for the normalized glucose values of the whole cerebellum between the control group (0.94 +/- 0.06) and PD patients (1.01 +/- 0.04; P < 0.05) but not for the mRT group (0.97 +/- 0.03). Our findings indicate that monosymptomatic resting tremor represents a phenotype of Parkinson's disease, with a nearly identical striatal dopaminergic deficit and postsynaptic D2-receptor upregulation in both patient groups. We suggest that the cerebellar metabolic hyperactivity in PD is closer related to akinesia and rigidity rather than to tremor.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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