Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease.
Identifieur interne : 000732 ( Ncbi/Curation ); précédent : 000731; suivant : 000733Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease.
Auteurs : Pablo Martínez-Martín [Espagne] ; Francesc Valldeoriola ; Eduardo Tolosa ; Manuela Pilleri ; José Luis Molinuevo ; Jordi Rumià ; Enric FerrerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- Adult, Aged, Dominance, Cerebral (physiology), Electric Stimulation Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurologic Examination, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Quality of Life, Subthalamic Nucleus (physiopathology).
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Dominance, Cerebral.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Electric Stimulation Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurologic Examination, Quality of Life.
Abstract
We examined the impact of the subthalamic nuclei (STN) deep brain stimulation (DBS) on the health-related quality of life (QoL) of patients with advanced Parkinson's disease (PD). Seventeen consecutive patients with refractory motor fluctuations and dyskinesia were included in the study (mean age, 60.9 +/- 7.7 years [range, 43-74 years]; disease duration, 16.4 +/- 8.5 years [range, 7-38 years]; mean off-medication Hoehn and Yahr stage, 4.23 +/- 0.66 [range, 2.5-5]). Each patient's assessment was carried out using common rating scales, following the Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol. Dyskinesia and emotional state were evaluated through the Abnormal Involuntary Movement Scale (AIMS) and the Hospital Anxiety and Depression Scale (HAD). QoL was assessed by means of the Parkinson's Disease Questionnaire Spanish version (PDQ-39). Significant benefit was obtained in the motor manifestations and complications of disease, as well as in the functional state and mood (P < 0.001). Some QoL dimensions (mobility and activities of daily living) and the PDQ-39 Summary Index (PDQ-39SI) showed a significant improvement (P < 0.001). Benefit was modest (P < 0.05) for three other domains (emotional well-being, stigma, bodily discomfort) and nil for the rest. There was no correlation between the change obtained in the QoL (PDQ-39SI) and in the other variables. As measured by the PDQ-39, STN-DBS significantly improves important aspects of QoL in patients with advanced PD.
PubMed: 11921126
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease.</title><author><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martínez-Martín">Pablo Martínez-Martín</name><affiliation wicri:level="3"><nlm:affiliation>Department of Applied Epidemiology, National Center of Epidemiology, I.S. Carlos III, Madrid, Spain. pmartinez@isciii.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Applied Epidemiology, National Center of Epidemiology, I.S. Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Pilleri, Manuela" sort="Pilleri, Manuela" uniqKey="Pilleri M" first="Manuela" last="Pilleri">Manuela Pilleri</name></author><author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José Luis" last="Molinuevo">José Luis Molinuevo</name></author><author><name sortKey="Rumia, Jordi" sort="Rumia, Jordi" uniqKey="Rumia J" first="Jordi" last="Rumià">Jordi Rumià</name></author><author><name sortKey="Ferrer, Enric" sort="Ferrer, Enric" uniqKey="Ferrer E" first="Enric" last="Ferrer">Enric Ferrer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:11921126</idno><idno type="pmid">11921126</idno><idno type="wicri:Area/PubMed/Corpus">003B19</idno><idno type="wicri:Area/PubMed/Curation">003B19</idno><idno type="wicri:Area/PubMed/Checkpoint">003B82</idno><idno type="wicri:Area/Ncbi/Merge">000732</idno><idno type="wicri:Area/Ncbi/Curation">000732</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease.</title><author><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martínez-Martín">Pablo Martínez-Martín</name><affiliation wicri:level="3"><nlm:affiliation>Department of Applied Epidemiology, National Center of Epidemiology, I.S. Carlos III, Madrid, Spain. pmartinez@isciii.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Applied Epidemiology, National Center of Epidemiology, I.S. Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Pilleri, Manuela" sort="Pilleri, Manuela" uniqKey="Pilleri M" first="Manuela" last="Pilleri">Manuela Pilleri</name></author><author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José Luis" last="Molinuevo">José Luis Molinuevo</name></author><author><name sortKey="Rumia, Jordi" sort="Rumia, Jordi" uniqKey="Rumia J" first="Jordi" last="Rumià">Jordi Rumià</name></author><author><name sortKey="Ferrer, Enric" sort="Ferrer, Enric" uniqKey="Ferrer E" first="Enric" last="Ferrer">Enric Ferrer</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Dominance, Cerebral (physiology)</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Quality of Life</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Quality of Life</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the impact of the subthalamic nuclei (STN) deep brain stimulation (DBS) on the health-related quality of life (QoL) of patients with advanced Parkinson's disease (PD). Seventeen consecutive patients with refractory motor fluctuations and dyskinesia were included in the study (mean age, 60.9 +/- 7.7 years [range, 43-74 years]; disease duration, 16.4 +/- 8.5 years [range, 7-38 years]; mean off-medication Hoehn and Yahr stage, 4.23 +/- 0.66 [range, 2.5-5]). Each patient's assessment was carried out using common rating scales, following the Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol. Dyskinesia and emotional state were evaluated through the Abnormal Involuntary Movement Scale (AIMS) and the Hospital Anxiety and Depression Scale (HAD). QoL was assessed by means of the Parkinson's Disease Questionnaire Spanish version (PDQ-39). Significant benefit was obtained in the motor manifestations and complications of disease, as well as in the functional state and mood (P < 0.001). Some QoL dimensions (mobility and activities of daily living) and the PDQ-39 Summary Index (PDQ-39SI) showed a significant improvement (P < 0.001). Benefit was modest (P < 0.05) for three other domains (emotional well-being, stigma, bodily discomfort) and nil for the rest. There was no correlation between the change obtained in the QoL (PDQ-39SI) and in the other variables. As measured by the PDQ-39, STN-DBS significantly improves important aspects of QoL in patients with advanced PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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