Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory study.
Identifieur interne : 000715 ( Ncbi/Curation ); précédent : 000714; suivant : 000716Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory study.
Auteurs : Gilberto Levy [États-Unis] ; Ming-Xin Tang ; Lucien J. Cote ; Elan D. Louis ; Brenda Alfaro ; Helen Mejia ; Yaakov Stern ; Karen MarderSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (diagnosis), Alzheimer Disease (epidemiology), Alzheimer Disease (etiology), Cohort Studies, Comorbidity, Dementia (diagnosis), Dementia (epidemiology), Dementia (etiology), Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, New York City (epidemiology), Parkinson Disease (diagnosis), Parkinson Disease (epidemiology), Parkinson Disease (etiology), Proportional Hazards Models, Risk Factors.
- MESH :
- geographic , epidemiology : New York City.
- diagnosis : Alzheimer Disease, Dementia, Parkinson Disease.
- epidemiology : Alzheimer Disease, Dementia, Parkinson Disease.
- etiology : Alzheimer Disease, Dementia, Parkinson Disease.
- Aged, Aged, 80 and over, Cohort Studies, Comorbidity, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Proportional Hazards Models, Risk Factors.
Abstract
The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 +/- 10.3 years), 52 (29%) became demented during a mean follow-up period of 3.6 +/- 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4-2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4-1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3-2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with nonsmokers (RR, 2.0; 95% CI, 1.0-3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2-16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9-3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study.
PubMed: 11921109
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pubmed:11921109Le document en format XML
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<front><div type="abstract" xml:lang="en">The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 +/- 10.3 years), 52 (29%) became demented during a mean follow-up period of 3.6 +/- 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4-2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4-1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3-2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with nonsmokers (RR, 2.0; 95% CI, 1.0-3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2-16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9-3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study.</div>
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