Quality of life outcomes following surgical treatment of Parkinson's disease.
Identifieur interne : 000654 ( Ncbi/Curation ); précédent : 000653; suivant : 000655Quality of life outcomes following surgical treatment of Parkinson's disease.
Auteurs : Alastair Gray [Royaume-Uni] ; Iain Mcnamara ; Tipu Aziz ; Ralph Gregory ; Peter Bain ; Joanna Wilson ; Richard ScottSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- methods : Neurosurgical Procedures.
- surgery : Brain, Globus Pallidus, Parkinson Disease, Thalamus.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Quality of Life, Questionnaires.
Abstract
We assessed the impact of surgical treatment of Parkinson's disease on quality of life using generic quality of life instruments and utility scores. The Medical Outcomes Study short form health survey SF-36 and Parkinson's Disease Questionnaire PDQ-39 were used before and 3-6 months after surgery to assess quality of life, and the results were converted into utility valuations. Ninety-seven patients were studied; 33 underwent unilateral thalamotomy, 33 unilateral pallidotomy, 20 bilateral pallidotomy, six subthalamic nucleus (STN) lesions, four mixed lesions, and in one case bilateral STN stimulation. All dimensions of the SF-36 except role mental and mental health showed statistically significant improvement following surgery. The PDQ-39 recorded significant improvements in the mobility, stigma, and bodily discomfort dimensions. The rating scale and time trade-off scales showed statistically significant gains in utility of 8% and 3%, respectively. Gains were particularly marked in the bilateral pallidotomy group. Differences in patient characteristics and selection made direct comparisons between procedures unreliable. Quality of life in patients with advanced Parkinson's disease is amenable to measurement; such measurement provides tentative evidence of significant gains in quality of life following some neurosurgical procedures.
PubMed: 11835441
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last="Mcnamara">Iain Mcnamara</name></author><author><name sortKey="Aziz, Tipu" sort="Aziz, Tipu" uniqKey="Aziz T" first="Tipu" last="Aziz">Tipu Aziz</name></author><author><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name></author><author><name sortKey="Bain, Peter" sort="Bain, Peter" uniqKey="Bain P" first="Peter" last="Bain">Peter Bain</name></author><author><name sortKey="Wilson, Joanna" sort="Wilson, Joanna" uniqKey="Wilson J" first="Joanna" last="Wilson">Joanna Wilson</name></author><author><name sortKey="Scott, Richard" sort="Scott, Richard" uniqKey="Scott R" first="Richard" last="Scott">Richard Scott</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:11835441</idno><idno type="pmid">11835441</idno><idno type="wicri:Area/PubMed/Corpus">003B97</idno><idno type="wicri:Area/PubMed/Curation">003B97</idno><idno 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d'Oxford</orgName></affiliation></author><author><name sortKey="Mcnamara, Iain" sort="Mcnamara, Iain" uniqKey="Mcnamara I" first="Iain" last="Mcnamara">Iain Mcnamara</name></author><author><name sortKey="Aziz, Tipu" sort="Aziz, Tipu" uniqKey="Aziz T" first="Tipu" last="Aziz">Tipu Aziz</name></author><author><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name></author><author><name sortKey="Bain, Peter" sort="Bain, Peter" uniqKey="Bain P" first="Peter" last="Bain">Peter Bain</name></author><author><name sortKey="Wilson, Joanna" sort="Wilson, Joanna" uniqKey="Wilson J" first="Joanna" last="Wilson">Joanna Wilson</name></author><author><name sortKey="Scott, Richard" sort="Scott, Richard" uniqKey="Scott R" first="Richard" last="Scott">Richard Scott</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno 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over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the impact of surgical treatment of Parkinson's disease on quality of life using generic quality of life instruments and utility scores. The Medical Outcomes Study short form health survey SF-36 and Parkinson's Disease Questionnaire PDQ-39 were used before and 3-6 months after surgery to assess quality of life, and the results were converted into utility valuations. Ninety-seven patients were studied; 33 underwent unilateral thalamotomy, 33 unilateral pallidotomy, 20 bilateral pallidotomy, six subthalamic nucleus (STN) lesions, four mixed lesions, and in one case bilateral STN stimulation. All dimensions of the SF-36 except role mental and mental health showed statistically significant improvement following surgery. The PDQ-39 recorded significant improvements in the mobility, stigma, and bodily discomfort dimensions. The rating scale and time trade-off scales showed statistically significant gains in utility of 8% and 3%, respectively. Gains were particularly marked in the bilateral pallidotomy group. Differences in patient characteristics and selection made direct comparisons between procedures unreliable. Quality of life in patients with advanced Parkinson's disease is amenable to measurement; such measurement provides tentative evidence of significant gains in quality of life following some neurosurgical procedures.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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