Involvement of the motor cortex in pseudochoreoathetosis.
Identifieur interne : 000584 ( Ncbi/Curation ); précédent : 000583; suivant : 000585Involvement of the motor cortex in pseudochoreoathetosis.
Auteurs : L. Timmermann [Allemagne] ; J. Gross ; F. Schmitz ; H J Freund ; A. SchnitzlerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Athetosis (etiology), Athetosis (physiopathology), Case-Control Studies, Chorea (etiology), Chorea (physiopathology), Electromyography, Female, Hand, Humans, Magnetoencephalography, Male, Middle Aged, Motor Cortex (physiopathology), Motor Neurons, Muscle, Skeletal (physiopathology), Psychomotor Performance, Sensation Disorders (etiology).
- MESH :
- etiology : Athetosis, Chorea, Sensation Disorders.
- physiopathology : Athetosis, Chorea, Motor Cortex, Muscle, Skeletal.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Electromyography, Female, Hand, Humans, Magnetoencephalography, Male, Middle Aged, Motor Neurons, Psychomotor Performance.
Abstract
The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age-matched controls cortical activity with a whole-head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG-EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG-EMG coherence in patients was similar to that of controls. Cortical sources of MEG-EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG-EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation.
PubMed: 11746617
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003C67
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :003C67
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003D17
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000584
Links to Exploration step
pubmed:11746617Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Involvement of the motor cortex in pseudochoreoathetosis.</title><author><name sortKey="Timmermann, L" sort="Timmermann, L" uniqKey="Timmermann L" first="L" last="Timmermann">L. Timmermann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Heinrich-Heine University, Duesseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Heinrich-Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Gross, J" sort="Gross, J" uniqKey="Gross J" first="J" last="Gross">J. Gross</name></author><author><name sortKey="Schmitz, F" sort="Schmitz, F" uniqKey="Schmitz F" first="F" last="Schmitz">F. Schmitz</name></author><author><name sortKey="Freund, H J" sort="Freund, H J" uniqKey="Freund H" first="H J" last="Freund">H J Freund</name></author><author><name sortKey="Schnitzler, A" sort="Schnitzler, A" uniqKey="Schnitzler A" first="A" last="Schnitzler">A. Schnitzler</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11746617</idno><idno type="pmid">11746617</idno><idno type="wicri:Area/PubMed/Corpus">003C67</idno><idno type="wicri:Area/PubMed/Curation">003C67</idno><idno type="wicri:Area/PubMed/Checkpoint">003D17</idno><idno type="wicri:Area/Ncbi/Merge">000584</idno><idno type="wicri:Area/Ncbi/Curation">000584</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Involvement of the motor cortex in pseudochoreoathetosis.</title><author><name sortKey="Timmermann, L" sort="Timmermann, L" uniqKey="Timmermann L" first="L" last="Timmermann">L. Timmermann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Heinrich-Heine University, Duesseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Heinrich-Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Gross, J" sort="Gross, J" uniqKey="Gross J" first="J" last="Gross">J. Gross</name></author><author><name sortKey="Schmitz, F" sort="Schmitz, F" uniqKey="Schmitz F" first="F" last="Schmitz">F. Schmitz</name></author><author><name sortKey="Freund, H J" sort="Freund, H J" uniqKey="Freund H" first="H J" last="Freund">H J Freund</name></author><author><name sortKey="Schnitzler, A" sort="Schnitzler, A" uniqKey="Schnitzler A" first="A" last="Schnitzler">A. Schnitzler</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Athetosis (etiology)</term><term>Athetosis (physiopathology)</term><term>Case-Control Studies</term><term>Chorea (etiology)</term><term>Chorea (physiopathology)</term><term>Electromyography</term><term>Female</term><term>Hand</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor Neurons</term><term>Muscle, Skeletal (physiopathology)</term><term>Psychomotor Performance</term><term>Sensation Disorders (etiology)</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Athetosis</term><term>Chorea</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Athetosis</term><term>Chorea</term><term>Motor Cortex</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Electromyography</term><term>Female</term><term>Hand</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Motor Neurons</term><term>Psychomotor Performance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age-matched controls cortical activity with a whole-head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG-EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG-EMG coherence in patients was similar to that of controls. Cortical sources of MEG-EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG-EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000584 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000584 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:11746617
|texte= Involvement of the motor cortex in pseudochoreoathetosis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:11746617" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |