Impairment of eyeblink classical conditioning in progressive supranuclear palsy.
Identifieur interne : 000466 ( Ncbi/Curation ); précédent : 000465; suivant : 000467Impairment of eyeblink classical conditioning in progressive supranuclear palsy.
Auteurs : M. Sommer [États-Unis] ; J. Grafman ; I. Litvan ; M. HallettSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Aged, Blinking (physiology), Cerebellar Nuclei (physiopathology), Conditioning, Classical (physiology), Electromyography, Female, Humans, Learning Disorders (diagnosis), Male, Memory Disorders (diagnosis), Middle Aged, Psychological Tests, Reaction Time, Sensory Thresholds (physiology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (physiopathology).
- MESH :
- diagnosis : Learning Disorders, Memory Disorders, Supranuclear Palsy, Progressive.
- physiology : Blinking, Conditioning, Classical, Sensory Thresholds.
- physiopathology : Cerebellar Nuclei, Supranuclear Palsy, Progressive.
- Aged, Electromyography, Female, Humans, Male, Middle Aged, Psychological Tests, Reaction Time.
Abstract
In a previous study we showed that learning in eyeblink classical conditioning (EBCC) is normal in Parkinson's disease (PD) and that the serial reaction time task (SRTT) is only marginally impaired. Since pathological lesions are more widespread in the atypical parkinsonian disorder of progressive supranuclear palsy (PSP) than in PD, we hypothesized that PSP patients may show more profound deficits in the EBCC and SRTT learning tasks. We therefore investigated EBCC with a delay and two trace paradigms, an SRTT and the California Verbal Learning Test (CVLT) in eight patients with PSP and an age-matched control group. In all EBCC paradigms, we found a significant difference between groups with no significant learning in PSP patients. In the SRTT, implicit learning may have been impaired, but verbal and manual sequence recall were only marginally impaired. Verbal memory was significantly worse in PSP patients than in the control group. Our study shows a dissociated pattern of learning abilities in PSP, where the EBCC as a measure of implicit learning is impaired, the explicit sequence detection in the SRTT is relatively preserved, and the verbal memory impaired. We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PD and PSP patients.
PubMed: 11295776
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impairment of eyeblink classical conditioning in progressive supranuclear palsy.</title><author><name sortKey="Sommer, M" sort="Sommer, M" uniqKey="Sommer M" first="M" last="Sommer">M. Sommer</name><affiliation wicri:level="1"><nlm:affiliation>Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Grafman, J" sort="Grafman, J" uniqKey="Grafman J" first="J" last="Grafman">J. Grafman</name></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I" last="Litvan">I. Litvan</name></author><author><name sortKey="Hallett, M" sort="Hallett, M" uniqKey="Hallett M" first="M" last="Hallett">M. Hallett</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11295776</idno><idno type="pmid">11295776</idno><idno type="wicri:Area/PubMed/Corpus">003D85</idno><idno type="wicri:Area/PubMed/Curation">003D85</idno><idno type="wicri:Area/PubMed/Checkpoint">003D25</idno><idno type="wicri:Area/Ncbi/Merge">000466</idno><idno type="wicri:Area/Ncbi/Curation">000466</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impairment of eyeblink classical conditioning in progressive supranuclear palsy.</title><author><name sortKey="Sommer, M" sort="Sommer, M" uniqKey="Sommer M" first="M" last="Sommer">M. Sommer</name><affiliation wicri:level="1"><nlm:affiliation>Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Grafman, J" sort="Grafman, J" uniqKey="Grafman J" first="J" last="Grafman">J. Grafman</name></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I" last="Litvan">I. Litvan</name></author><author><name sortKey="Hallett, M" sort="Hallett, M" uniqKey="Hallett M" first="M" last="Hallett">M. Hallett</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blinking (physiology)</term><term>Cerebellar Nuclei (physiopathology)</term><term>Conditioning, Classical (physiology)</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Learning Disorders (diagnosis)</term><term>Male</term><term>Memory Disorders (diagnosis)</term><term>Middle Aged</term><term>Psychological Tests</term><term>Reaction Time</term><term>Sensory Thresholds (physiology)</term><term>Supranuclear Palsy, Progressive (diagnosis)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Learning Disorders</term><term>Memory Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blinking</term><term>Conditioning, Classical</term><term>Sensory Thresholds</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellar Nuclei</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Psychological Tests</term><term>Reaction Time</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a previous study we showed that learning in eyeblink classical conditioning (EBCC) is normal in Parkinson's disease (PD) and that the serial reaction time task (SRTT) is only marginally impaired. Since pathological lesions are more widespread in the atypical parkinsonian disorder of progressive supranuclear palsy (PSP) than in PD, we hypothesized that PSP patients may show more profound deficits in the EBCC and SRTT learning tasks. We therefore investigated EBCC with a delay and two trace paradigms, an SRTT and the California Verbal Learning Test (CVLT) in eight patients with PSP and an age-matched control group. In all EBCC paradigms, we found a significant difference between groups with no significant learning in PSP patients. In the SRTT, implicit learning may have been impaired, but verbal and manual sequence recall were only marginally impaired. Verbal memory was significantly worse in PSP patients than in the control group. Our study shows a dissociated pattern of learning abilities in PSP, where the EBCC as a measure of implicit learning is impaired, the explicit sequence detection in the SRTT is relatively preserved, and the verbal memory impaired. We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PD and PSP patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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