Cognitive and behavioral changes after unilateral posteroventral pallidotomy: relationship with lesional data from MRI.
Identifieur interne : 000121 ( Ncbi/Curation ); précédent : 000120; suivant : 000122Cognitive and behavioral changes after unilateral posteroventral pallidotomy: relationship with lesional data from MRI.
Auteurs : C. Junqué [Espagne] ; M. Alegret ; F A Nobbe ; F. Valldeoriola ; R. Pueyo ; P. Vendrell ; E. Tolosa ; J. Rumià ; J M MercaderSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (diagnosis), Female, Functional Laterality (physiology), Globus Pallidus (pathology), Globus Pallidus (surgery), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Obsessive-Compulsive Disorder (diagnosis), Parkinson Disease (surgery), Postoperative Complications (diagnosis), Severity of Illness Index, Time Factors, Ventral Thalamic Nuclei (pathology), Ventral Thalamic Nuclei (surgery).
- MESH :
- diagnosis : Cognition Disorders, Obsessive-Compulsive Disorder, Postoperative Complications.
- pathology : Globus Pallidus, Ventral Thalamic Nuclei.
- physiology : Functional Laterality.
- surgery : Globus Pallidus, Parkinson Disease, Ventral Thalamic Nuclei.
- Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Time Factors.
Abstract
We investigated cognitive and behavioral changes after unilateral posteroventral pallidotomy, and their relationship with lesion size and location as identified in magnetic resonance image quantitative analysis. Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3-month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive-compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right-sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. These regions accounted for 68% of the variance in the visuospatial changes.
PubMed: 10495039
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Alegret</name></author><author><name sortKey="Nobbe, F A" sort="Nobbe, F A" uniqKey="Nobbe F" first="F A" last="Nobbe">F A Nobbe</name></author><author><name sortKey="Valldeoriola, F" sort="Valldeoriola, F" uniqKey="Valldeoriola F" first="F" last="Valldeoriola">F. Valldeoriola</name></author><author><name sortKey="Pueyo, R" sort="Pueyo, R" uniqKey="Pueyo R" first="R" last="Pueyo">R. Pueyo</name></author><author><name sortKey="Vendrell, P" sort="Vendrell, P" uniqKey="Vendrell P" first="P" last="Vendrell">P. Vendrell</name></author><author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name></author><author><name sortKey="Rumia, J" sort="Rumia, J" uniqKey="Rumia J" first="J" last="Rumià">J. Rumià</name></author><author><name sortKey="Mercader, J M" sort="Mercader, J M" uniqKey="Mercader J" first="J M" last="Mercader">J M Mercader</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10495039</idno><idno type="pmid">10495039</idno><idno type="wicri:Area/PubMed/Corpus">004130</idno><idno type="wicri:Area/PubMed/Curation">004130</idno><idno type="wicri:Area/PubMed/Checkpoint">004244</idno><idno type="wicri:Area/Ncbi/Merge">000121</idno><idno type="wicri:Area/Ncbi/Curation">000121</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cognitive and behavioral changes after unilateral posteroventral pallidotomy: relationship with lesional data from MRI.</title><author><name sortKey="Junque, C" sort="Junque, C" uniqKey="Junque C" first="C" last="Junqué">C. Junqué</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer</wicri:regionArea><wicri:noRegion>Institut d'Investigacions Biomèdiques August Pi i Sunyer</wicri:noRegion></affiliation></author><author><name sortKey="Alegret, M" sort="Alegret, M" uniqKey="Alegret M" first="M" last="Alegret">M. Alegret</name></author><author><name sortKey="Nobbe, F A" sort="Nobbe, F A" uniqKey="Nobbe F" first="F A" last="Nobbe">F A Nobbe</name></author><author><name sortKey="Valldeoriola, F" sort="Valldeoriola, F" uniqKey="Valldeoriola F" first="F" last="Valldeoriola">F. Valldeoriola</name></author><author><name sortKey="Pueyo, R" sort="Pueyo, R" uniqKey="Pueyo R" first="R" last="Pueyo">R. Pueyo</name></author><author><name sortKey="Vendrell, P" sort="Vendrell, P" uniqKey="Vendrell P" first="P" last="Vendrell">P. Vendrell</name></author><author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name></author><author><name sortKey="Rumia, J" sort="Rumia, J" uniqKey="Rumia J" first="J" last="Rumià">J. Rumià</name></author><author><name sortKey="Mercader, J M" sort="Mercader, J M" uniqKey="Mercader J" first="J M" last="Mercader">J M Mercader</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition Disorders (diagnosis)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Globus Pallidus (pathology)</term><term>Globus Pallidus (surgery)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Obsessive-Compulsive Disorder (diagnosis)</term><term>Parkinson Disease (surgery)</term><term>Postoperative Complications (diagnosis)</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Ventral Thalamic Nuclei (pathology)</term><term>Ventral Thalamic Nuclei (surgery)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Obsessive-Compulsive Disorder</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Globus Pallidus</term><term>Ventral Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease</term><term>Ventral Thalamic Nuclei</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated cognitive and behavioral changes after unilateral posteroventral pallidotomy, and their relationship with lesion size and location as identified in magnetic resonance image quantitative analysis. Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3-month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive-compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right-sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. These regions accounted for 68% of the variance in the visuospatial changes.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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