Planning and executing an action in Parkinson's disease.
Identifieur interne : 005099 ( Ncbi/Checkpoint ); précédent : 005098; suivant : 005100Planning and executing an action in Parkinson's disease.
Auteurs : M. Gentilucci [Italie] ; A. NegrottiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Attention, Motor Skills, Orientation, Psychomotor Performance, Reaction Time.
- physiopathology : Basal Ganglia, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
We evaluated the possible impairment in planning and executing an action in patients with Parkinson's disease (PD). The action considered in the present study was formed by two successive motor acts: reaching-grasping an object (first target) and placing it on a second target of the same shape and size. We examined the effects of extrinsic properties of the second target (that is, distance) on the various kinematic phases of reaching-grasping movements. Distance, position, and size of both stimuli were randomly varied across the experimental session. Movements were executed with and without visual control of both targets and arm. The performance of six patients with PD was compared with an age-matched control group. The kinematics of the initial phase of reaching was influenced by position and size of the first target and by distance of the second target in both patients and control subjects. In particular, peak acceleration was higher for farther position of the second target. However, in the subsequent phase patients, differently from control subjects, removed the effects of the second target distance by modifying their reaching kinematics. This was obtained by varying the duration of the acceleration phase. In summary, the patients reprogrammed the reaching component by taking into account only the properties of the first target. The decreasing influence of second-target distance on reaching kinematics of patients was more evident during movements executed under visual control. Moreover, their movements executed without visual control were slowed down from the beginning. The second target affected the grasping kinematics only of the control subjects. Globally, these results indicate that PD patients are able to compute the general program of an action that takes into account extrinsic properties of the final target. However, the finding that PD patients reprogrammed the movement during its execution suggests a decay of the program during its time course, that is, basal ganglia can be involved in storing the plan of an action and in controlling its correct execution.
PubMed: 9918347
Affiliations:
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Negrotti</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:9918347</idno><idno type="pmid">9918347</idno><idno type="wicri:Area/PubMed/Corpus">004284</idno><idno type="wicri:Area/PubMed/Curation">004284</idno><idno type="wicri:Area/PubMed/Checkpoint">004135</idno><idno type="wicri:Area/Ncbi/Merge">005099</idno><idno type="wicri:Area/Ncbi/Curation">005099</idno><idno type="wicri:Area/Ncbi/Checkpoint">005099</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Planning and executing an action in Parkinson's disease.</title><author><name sortKey="Gentilucci, M" sort="Gentilucci, M" uniqKey="Gentilucci M" first="M" last="Gentilucci">M. Gentilucci</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Human Physiology, University of Parma, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Human Physiology, University of Parma</wicri:regionArea><wicri:noRegion>University of Parma</wicri:noRegion></affiliation></author><author><name sortKey="Negrotti, A" sort="Negrotti, A" uniqKey="Negrotti A" first="A" last="Negrotti">A. Negrotti</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Attention (physiology)</term><term>Basal Ganglia (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Skills (physiology)</term><term>Orientation (physiology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Reaction Time (physiology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Motor Skills</term><term>Orientation</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the possible impairment in planning and executing an action in patients with Parkinson's disease (PD). The action considered in the present study was formed by two successive motor acts: reaching-grasping an object (first target) and placing it on a second target of the same shape and size. We examined the effects of extrinsic properties of the second target (that is, distance) on the various kinematic phases of reaching-grasping movements. Distance, position, and size of both stimuli were randomly varied across the experimental session. Movements were executed with and without visual control of both targets and arm. The performance of six patients with PD was compared with an age-matched control group. The kinematics of the initial phase of reaching was influenced by position and size of the first target and by distance of the second target in both patients and control subjects. In particular, peak acceleration was higher for farther position of the second target. However, in the subsequent phase patients, differently from control subjects, removed the effects of the second target distance by modifying their reaching kinematics. This was obtained by varying the duration of the acceleration phase. In summary, the patients reprogrammed the reaching component by taking into account only the properties of the first target. The decreasing influence of second-target distance on reaching kinematics of patients was more evident during movements executed under visual control. Moreover, their movements executed without visual control were slowed down from the beginning. The second target affected the grasping kinematics only of the control subjects. Globally, these results indicate that PD patients are able to compute the general program of an action that takes into account extrinsic properties of the final target. However, the finding that PD patients reprogrammed the movement during its execution suggests a decay of the program during its time course, that is, basal ganglia can be involved in storing the plan of an action and in controlling its correct execution.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Negrotti, A" sort="Negrotti, A" uniqKey="Negrotti A" first="A" last="Negrotti">A. Negrotti</name></noCountry><country name="Italie"><noRegion><name sortKey="Gentilucci, M" sort="Gentilucci, M" uniqKey="Gentilucci M" first="M" last="Gentilucci">M. Gentilucci</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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