Unified Huntington's disease rating scale: a follow up.
Identifieur interne : 005072 ( Ncbi/Checkpoint ); précédent : 005071; suivant : 005073Unified Huntington's disease rating scale: a follow up.
Auteurs : S. Siesling [Pays-Bas] ; J P Van Vugt ; K A Zwinderman ; K. Kieburtz ; R A RoosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Activities of Daily Living, Adult, Aged, Analysis of Variance, Disease Progression, Female, Follow-Up Studies, Humans, Huntington Disease (classification), Huntington Disease (diagnosis), Longitudinal Studies, Male, Middle Aged, Neurologic Examination (statistics & numerical data), Psychometrics, Statistics, Nonparametric.
- MESH :
- classification : Huntington Disease.
- diagnosis : Huntington Disease.
- statistics & numerical data : Neurologic Examination.
- Activities of Daily Living, Adult, Aged, Analysis of Variance, Disease Progression, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Psychometrics, Statistics, Nonparametric.
Abstract
An objective assessment of the clinical findings in patients with Huntington's disease (HD) is necessary for an evaluation of the longitudinal progression of the disease features. The Unified Huntington's Disease Rating Scale (UHDRS) is a scale to assess clinical performance and functional capacity. The authors examined the 1-year change in UHDRS scores in 78 patients with HD examined either in Leiden, the Netherlands (24 men, 25 women), or in Rochester, New York, United States (12 men, 17 women). A significant decline was seen in motor function, measured with the total motor scale. The total dystonia score increased significantly; the total chorea score did not. The frequency of behavioral disorders tended to increase. The scores on independence scale, functional assessment, total functional capacity, and symbol digit decreased significantly. No relation was observed between the UHDRS items and the age at onset or duration of illness. Thirteen patients with 2-year follow up showed a clear increase in score on the total motor scale and a decline on the independence scale and in total functional capacity. The UHDRS may also be used as a tool for determining therapeutic intervention. Annual evaluation of the total motor scale in every patient gives a clear description of the motor progression of the disease. The authors suggest performing a total UHDRS evaluation every second year for every HD patient as part of the routine longitudinal evaluation.
DOI: 10.1002/mds.870130609
PubMed: 9827615
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Unified Huntington's disease rating scale: a follow up.</title><author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S" last="Siesling">S. Siesling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Centre, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Van Vugt, J P" sort="Van Vugt, J P" uniqKey="Van Vugt J" first="J P" last="Van Vugt">J P Van Vugt</name></author><author><name sortKey="Zwinderman, K A" sort="Zwinderman, K A" uniqKey="Zwinderman K" first="K A" last="Zwinderman">K A Zwinderman</name></author><author><name sortKey="Kieburtz, K" sort="Kieburtz, K" uniqKey="Kieburtz K" first="K" last="Kieburtz">K. Kieburtz</name></author><author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9827615</idno><idno type="pmid">9827615</idno><idno type="doi">10.1002/mds.870130609</idno><idno type="wicri:Area/PubMed/Corpus">004311</idno><idno type="wicri:Area/PubMed/Curation">004311</idno><idno type="wicri:Area/PubMed/Checkpoint">004305</idno><idno type="wicri:Area/Ncbi/Merge">005072</idno><idno type="wicri:Area/Ncbi/Curation">005072</idno><idno type="wicri:Area/Ncbi/Checkpoint">005072</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Unified Huntington's disease rating scale: a follow up.</title><author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S" last="Siesling">S. Siesling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Centre, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Van Vugt, J P" sort="Van Vugt, J P" uniqKey="Van Vugt J" first="J P" last="Van Vugt">J P Van Vugt</name></author><author><name sortKey="Zwinderman, K A" sort="Zwinderman, K A" uniqKey="Zwinderman K" first="K A" last="Zwinderman">K A Zwinderman</name></author><author><name sortKey="Kieburtz, K" sort="Kieburtz, K" uniqKey="Kieburtz K" first="K" last="Kieburtz">K. Kieburtz</name></author><author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Huntington Disease (classification)</term><term>Huntington Disease (diagnosis)</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination (statistics & numerical data)</term><term>Psychometrics</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neurologic Examination</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Psychometrics</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An objective assessment of the clinical findings in patients with Huntington's disease (HD) is necessary for an evaluation of the longitudinal progression of the disease features. The Unified Huntington's Disease Rating Scale (UHDRS) is a scale to assess clinical performance and functional capacity. The authors examined the 1-year change in UHDRS scores in 78 patients with HD examined either in Leiden, the Netherlands (24 men, 25 women), or in Rochester, New York, United States (12 men, 17 women). A significant decline was seen in motor function, measured with the total motor scale. The total dystonia score increased significantly; the total chorea score did not. The frequency of behavioral disorders tended to increase. The scores on independence scale, functional assessment, total functional capacity, and symbol digit decreased significantly. No relation was observed between the UHDRS items and the age at onset or duration of illness. Thirteen patients with 2-year follow up showed a clear increase in score on the total motor scale and a decline on the independence scale and in total functional capacity. The UHDRS may also be used as a tool for determining therapeutic intervention. Annual evaluation of the total motor scale in every patient gives a clear description of the motor progression of the disease. The authors suggest performing a total UHDRS evaluation every second year for every HD patient as part of the routine longitudinal evaluation.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Kieburtz, K" sort="Kieburtz, K" uniqKey="Kieburtz K" first="K" last="Kieburtz">K. Kieburtz</name><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name><name sortKey="Van Vugt, J P" sort="Van Vugt, J P" uniqKey="Van Vugt J" first="J P" last="Van Vugt">J P Van Vugt</name><name sortKey="Zwinderman, K A" sort="Zwinderman, K A" uniqKey="Zwinderman K" first="K A" last="Zwinderman">K A Zwinderman</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S" last="Siesling">S. Siesling</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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