The detection of preclinical Parkinson's disease: what is the role of positron emission tomography?
Identifieur interne : 004954 ( Ncbi/Checkpoint ); précédent : 004953; suivant : 004955The detection of preclinical Parkinson's disease: what is the role of positron emission tomography?
Auteurs : G V Sawle [Royaume-Uni]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1993.
English descriptors
- KwdEn :
- Blood-Brain Barrier, Brain (metabolism), Brain (physiopathology), Brain (radionuclide imaging), Diagnosis, Differential, Dopamine (metabolism), Female, Humans, Levodopa (pharmacokinetics), Lewy Bodies, Male, Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Prospective Studies, Tomography, Emission-Computed (methods).
- MESH :
- chemical , metabolism : Dopamine.
- metabolism : Brain, Parkinson Disease.
- methods : Tomography, Emission-Computed.
- chemical , pharmacokinetics : Levodopa.
- physiopathology : Brain, Parkinson Disease.
- radionuclide imaging : Brain, Parkinson Disease.
- Blood-Brain Barrier, Diagnosis, Differential, Female, Humans, Lewy Bodies, Male, Prospective Studies.
Abstract
On clinical criteria alone, the diagnosis of early Parkinson's disease can be difficult and, by definition, the prospective recognition of preclinical Parkinson's disease is impossible. Positron emission tomography (PET) using [18F]dopa as tracer has been proposed as a means of identifying patients with preclinical disease. The number of subjects detected to date has been few; most have been identified by serendipity or during the course of family studies. This review examines the significance of a single abnormal scan in an apparently healthy subject in terms of the relationship between normal and abnormal values and the time course of the disease.
DOI: 10.1002/mds.870080304
PubMed: 8341290
Affiliations:
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pubmed:8341290Le document en format XML
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